5 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Browning metabolism and quality of fresh-cut drumstick (Moringa oleifera) as influenced by acidulant treatments
Microwave blanching and drying characteristics of Centella asiatica (L.) urban leaves using tray and heat pump-assisted dehumidified drying
Physical function and quality of life in patients with chronic graft-versus-host-disease: A summary of preclinical and clinical studies and a call for exercise intervention trials in patients
Allogeneic Hematopoietic Stem Cell Transplant, to reconstitute hematopoietic and immune status
of patients undergoing myeloablative therapy for hematologic disorders, has been of great benefit
in minimizing or eradicating disease and extending survival. Patients who undergo allogeneic
hematopoietic stem cell transplant (allo-HSCT) are subject to many comorbidities among which
the most significant, affecting quality of life (QoL) and survival, are acute (aGVHD) and chronic
Graft Versus Host Disease (cGVHD), resulting from donor lymphocytes reacting to and damaging
host tissues. Physical activity and exercise have clearly been shown, in both children and adults, to
enhance fitness, improve symptomatology and QoL, reduce disease progression and extend
survival for many diseases including malignancies. In some cases, vigorous exercise has been
shown to be equal to or more effective than pharmacologic therapy. This review addresses how
cGVHD affects patients’ physical function and physical domain of QoL, and the potential benefits
of exercise interventions along with recommendations for relevant research and evaluation targeted at incorporating this strategy as soon as possible after allo-HSCT and ideally, as soon as
possible upon diagnosis of the condition leading to allo-HSCT.Sin financiación3.874 JCR (2016) Q2, 20/70 Hematology, 48/151 Immunology, 71/217 Oncology, 7/25 Transplantation1.986 SJR (2016) Q1, 18/135 Hematology, 5/42 TransplantationNo data IDR 2016UE