Genetic insights on sleep schedules: this time, it's PERsonal.

The study of circadian rhythms is emerging as a fruitful opportunity for understanding cellular mechanisms that govern human physiology and behavior, fueled by evidence directly linking sleep disorders to genetic mutations affecting circadian molecular pathways. Familial advanced sleep-phase disorder (FASPD) is the first recognized Mendelian circadian rhythm trait, and affected individuals exhibit exceptionally early sleep-wake onset due to altered post-translational regulation of period homolog 2 (PER2). Behavioral and cellular circadian rhythms are analogously affected because the circadian period length of behavior is reduced in the absence of environmental time cues, and cycle duration of the molecular clock is likewise shortened. In light of these findings, we review the PER2 dynamics in the context of circadian regulation to reveal the mechanism of sleep-schedule modulation. Understanding PER2 regulation and functionality may shed new light on how our genetic composition can influence our sleep-wake behaviors

A plug-and-play ripple mitigation approach for DC-links in hybrid systems

© 2016 IEEE.In this paper, a plug-and-play ripple mitigation technique is proposed. It requires only the sensing of the DC-link voltage and can operate fully independently to remove the low-frequency voltage ripple. The proposed technique is nonintrusive to the existing hardware and enables hot-swap operation without disrupting the normal functionality of the existing power system. It is user-friendly, modular and suitable for plug-and-play operation. The experimental results demonstrate the effectiveness of the ripple-mitigation capability of the proposed device. The DC-link voltage ripple in a 110 W miniature hybrid system comprising an AC/DC converter and two resistive loads is shown to be significantly reduced from 61 V to only 3.3 V. Moreover, it is shown that with the proposed device, the system reliability has been improved by alleviating the components' thermal stresses

Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function.

Why do we need to sleep? What regulates when we sleep? And what dictates the number of hours we require? These are often viewed as three separate biological questions. Here, we propose they share molecular etiologies, whereby regulators of sleep schedules and sleep duration also govern the physiological purposes of sleep. To support our hypothesis, we review Mendelian human genetic variants sufficient to advance sleep-wake onset (PER2) and shorten sleep length (DEC2), and evaluate their emerging roles in immune responses that may rely on a sound night of slumber

Prevalence and awareness of lower urinary tract symptoms among males in the Outpatient Clinics of Universiti Kebangsaan Malaysia Medical Centre.

This study aims to determine the prevalence of lower urinary tract symptoms (LUTS) and level of awareness among male outpatients in Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A questionnaire consisting of demographic data, questions related to knowledge, attitude and practice on BPH and the International Prostate Symptom Score (IPSS) was used for this study. Uroflowmetry and bladder scan were used to evaluate the function of the urinary tract and severity of BPH. Urine dipstick was done for glycosuria, proteinuria and haematuria. A total of 220 respondents were surveyed. The prevalence of moderately and severely symptomatic LUTS was 42.7%. The most commonly reported LUTS were nocturia (78.2%), frequency (58.2%) and incomplete emptying (44.6%). The prevalence of glycosuria, proteinuria and haematuria were 23.6%, 11.4% and 1.8% respectively. There was a significant association between increasing age with the severity of LUTS (p=0.005). Out of 102 respondents with voided urine volume greater than 150 mL, there was a significant decrease in maximum (Qmax) (p=0.039) and average (Qave) urine flow rates with every 10 years increase of age (p=0.001). The majority of respondents (59.5%) have heard of BPH before. Over 78.2% of the respondents would seek medical attention if they have LUTS with 15.9% saying they would seek traditional treatment. In conclusion, the prevalence of LUTS was high and the level of awareness was satisfactory

Factors Influencing Perceptions Of University Students Towards Internet Recruitment

This study aims to determine the factors that influence the perceptions of university students towards Internet recruitment. Data were collected from 250 university students from five universities through self-reported questionnaires that were e-mailed to them. The results indicate that factors such as user friendliness, information provision, and website usability are significantly related to the perceptions of university students towards Internet recruitment. Amongst the three factors, information provision appears to be the strongest predictor. It can be concluded that Internet recruitment will continue to gain prominence, and employers must pay considerable attention to their online recruitment information, appearance, features, and functions if they wish to attract the right job candidates

Development of social media addiction scale for COVID-19 pandemic (SMACOP)

The current COVID-19 pandemic and ‘new normal’ has resulted in much distress worldwide. Social media currently plays an essential role in information gathering. Thus, time spent on social media has increased drastically, further increasing the risk for internet-related addictions, such as social media addiction. This study aimed to develop a COVID-19-related measure of social media addiction based on the Bergen Social Media Addiction Scale (BSMAS) in order to aid in the identification and evaluation of at-risk individuals. Social Media Addiction Scale for COVID-19 Pandemic (SMACOP) was adapted from BSMAS to fit the context of COVID-19 and pilot tested on 20 individuals. A total of 80 participants were subsequently recruited through convenience sampling from the general public of a public university in Malaysia, comprising of patients’ family, visitors, or hospital staff. Construct validity was assessed using the Insomnia Severity Index (ISI), Generalized Anxiety Disorder 7 (GAD7) and Patient Health Questionnaire (PHQ9). A two-factor structure was found for SMACOP, comprising of the factors ‘Desire’ and ‘Distress’. SMACOP shows good internal consistency (α = 0.64) and validity. SMACOP scores were positively correlated with the PHQ9, GAD7, and ISI (p<.01). SMACOP is a psychometrically valid instrument with high internal consistency, which is especially useful during this time in assessing social media addiction in relevance to COVID-19