Smartphone-Based pH Sensor for Home Monitoring of Pulmonary Exacerbations in Cystic Fibrosis.

Currently, Cystic Fibrosis (CF) patients lack the ability to track their lung health at home, relying instead on doctor checkups leading to delayed treatment and lung damage. By leveraging the ubiquity of the smartphone to lower costs and increase portability, a smartphone-based peripheral pH measurement device was designed to attach directly to the headphone port to harvest power and communicate with a smartphone application. This platform was tested using prepared pH buffers and sputum samples from CF patients. The system matches within ~0.03 pH of a benchtop pH meter while fully powering itself and communicating with a Samsung Galaxy S3 smartphone paired with either a glass or Iridium Oxide (IrOx) electrode. The IrOx electrodes were found to have 25% higher sensitivity than the glass probes at the expense of larger drift and matrix sensitivity that can be addressed with proper calibration. The smartphone-based platform has been demonstrated as a portable replacement for laboratory pH meters, and supports both highly robust glass probes and the sensitive and miniature IrOx electrodes with calibration. This tool can enable more frequent pH sputum tracking for CF patients to help detect the onset of pulmonary exacerbation to provide timely and appropriate treatment before serious damage occurs

Literature Review Reveals a Global Access Inequity to Urban Green Spaces

Differences in the accessibility to urban resources between different racial and socioeconomic groups have exerted pressure on effective planning and management for sustainable city development. However, few studies have examined the multiple factors that may influence the mitigation of urban green spaces (UGS) inequity. This study reports the results of a systematic mapping of access inequity research through correspondence analysis (CA) to reveal critical trends, knowledge gaps, and clusters based on a sample of 49 empirical studies screened from 563 selected papers. Our findings suggest that although the scale of cities with UGS access inequity varies between countries, large cities (more than 1,000,000 population), especially in low- and middle-income countries (LMICs), are particularly affected. Moreover, the number of cities in which high socioeconomic status (high-SES) groups (e.g., young, rich, or employed) are at an advantage concerning access to UGS is substantially higher than the number of cities showing better accessibility for low-SES groups. Across the reviewed papers, analyses on mitigating interventions are sparse, and among the few studies that touch upon this, we found different central issues in local mitigating strategies between high-income countries (HICs) and LMICs. An explanatory framework is offered, explaining the interaction between UGS access inequity and local mitigating measures

Accident black spot clustering oriented maritime search and rescue resource allocation and optimization

Efficient and rapid deployment of maritime search and rescue(MSAR) resources is a prerequisite for maritime emergency search and rescue, in order to improve the efficiency and accuracy of MSAR. This paper proposes an integrated approach for emergency resource allocation. The approach encompasses three main steps: identifying accident black spots, assessing high-risk areas, and optimizing the outcomes through a synergistic combination of an optimization algorithm and reinforcement learning. In the initial step, the paper introduces the iterative self-organizing data analysis technology (ISODATA) for identifying accident spots at sea. A comparative analysis is conducted with other clustering algorithms, highlighting the superiority of ISODATA in effectively conducting dense clustering. This can effectively carry out dense clustering, instead of the situation where the data spots are too dispersed or obvious anomalies that affect the clustering. Furthermore, this approach incorporates entropy weighting to reassess the significance of accident spots by considering both the distance and the frequency of accidents. This integrated approach enhances the allocation of search and rescue forces, ensuring more efficient resource utilization. To address the MSAR vessel scheduling problem at sea, the paper employs the non-dominated sorting genetic algorithm II combined with reinforcement learning (NSGAII-RL). Comparative evaluations against other optimization algorithms reveal that the proposed approach can save a minimum of 7% in search and rescue time, leading to enhanced stability and improved efficiency in large-scale MSAR operations. Overall, the integrated approach presented in this paper offers a robust solution to the ship scheduling problem in maritime search and rescue operations. Its effectiveness is demonstrated through improved resource allocation, enhanced timeliness, and higher efficiency in responding to maritime accidents

Influence of hyperuricemia on the reproductive function of female rats and its mechanism

Objective To investigate the influence of hyperuricemia (HUA) on the reproductive function of female rats and its mechanism. Methods A total of 18 female Wistar rats were randomly divided into HUA group, HUA recovery group (HR group), and control group (N group), with 6 rats in each group. The rats in the HUA group and the HR group were given intragastric administration of 50 mg/kg uric acid and intraperitoneal injection of 250 mg/kg oteracil potassium every day, and since week 9, the rats in the HR group were given an equal volume of normal saline by gavage and intraperitoneal injection, while the treatment remained unchanged for those in the HUA group, for another 7 weeks; the rats in the N group were given an equal vo-lume of normal saline by gavage and intraperitoneal injection for 16 weeks. At week 16, body weight, uterine mass, and ovarian mass were measured for all three groups, and uterine and ovarian coefficients were calculated; hematoxylin-eosin staining was used to observe the pathological changes of the uterus and ovarian tissue; enzyme-linked immunosorbent assay was used to measure the serum levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2); the vaginal exfoliation cell smear method was used to observe the estrous cycle of rats; colorimetry was used to measure the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) in uterine tissue of the three groups; immunofluorescence assay was used to measure the fluorescence intensity of tumor necrosis factor-α (TNF-α) in uterine tissue of the three groups. Results Compared with the N group, the HUA group had significant reductions in uterine coefficient, number of follicles, endometrial thickness, and estrous interval, a significant increase in the serum level of FSH, significant reductions in the levels of SOD and GSH in uterine tissue, and a significant increase in the content of MDA (F=7.80-111.40,t=3.95-12.37,P<0.05), as well as an increase in the fluorescence intensity of TNF-α in uterine tissue. Compared with the HUA group, the HR group had significant increases in the number of follicles, endometrial thickness, the serum level of FSH, and the levels of SOD and GSH in uterine tissue and a significant reduction in the level of MDA (t=3.40-11.56,P<0.05), as well as a reduction in the fluorescence intensity of TNF-α in uterine tissue. Conclusion HUA can cause the decline of reproductive function in female rats, which may be associated with the increase in the serum level of uric acid, the disorder of sex hormone secretion, the increase in the level of oxidative stress, and the induction of inflammatory response

Mini percutaneous nephrolithotomy is a noninferior modality to standard percutaneous nephrolithotomy for the management of 20-40 mm renal calculi: A Multicenter randomized controlled trial

Background: High quality of evidence comparing mini percutaneous nephrolithotomy (mPNL) with standard percutaneous nephrolithotomy (sPNL) for the treatment of larger-sized renal stones is lacking. Objective: To compare the efficacy and safety of mPNL and sPNL for the treatment of 20–40 mm renal stones. Design, setting, and participants: A parallel, open-label, and noninferior randomized controlled trial was performed at 20 Chinese centers (2016–2019). The inclusion criteria were patients 18–70 yr old, with normal renal function, and 20–40 mm renal stones. Intervention: Percutaneous nephrolithotomy PNL was performed using either 18 F or 24 F percutaneous nephrostomy tracts. Outcome measurements and statistical analysis: The primary outcome was the one-session stone-free rate (SFR). The secondary outcomes included operating time, visual analog pain scale (VAS) score, blood loss, complications as per the Clavien-Dindo grading system, and length of hospitalization. Results and limitations: The 1980 intention-to-treat patients were randomized. The mPNL group achieved a noninferior one-session SFR to the sPNL group by the one-side noninferiority test (0.5% [difference], p < 0.001). The transfusion and embolization rates were comparable; however, the sPNL group had a higher hemoglobin drop (5.2 g/l, p < 0.001). The sPNL yielded shorter operating time (–2.2 min, p = 0.008) but a higher VAS score (0.8, p < 0.001). Patients in the sPNL group also had longer hospitalization (0.6 d, p < 0.001). There was no statistically significant difference in fever or urosepsis occurrences. The study's main limitation was that only 18F or 24F tract sizes were used. Conclusions: Mini mPNL achieves noninferior SFR outcomes to sPNL, but with reduced bleeding, less postoperative pain, and shorter hospitalization. Patient summary: We evaluated the surgical outcomes of percutaneous nephrolithotomy using two different sizes of nephrostomy tracts in a large population. We found that the smaller tract might be a sensible alternative for patients with 20–40 mm renal stones. This multicenter, parallel, open-label, and noninferior randomized controlled trial showed that mini percutaneous nephrolithotomy achieved noninferior stone-free rate with advantages of reduced blood loss, less postoperative pain, and shorter hospitalization. Mini percutaneous nephrolithotomy should be considered a sensible alternative treatment of 20–40 mm renal stones.grants from high-level development funding of Guangzhou Medical Universit

Effects of Urbanization on the Dynamics and Equity of Access to Urban Parks from 2000 to 2015 in Beijing, China

Urban parks provide multiple ecosystem services as an important element of the urban space and improve human health and wellbeing. This study used the Gaussian-based 2SFCA method to evaluate the spatiotemporal distribution of and changes in park accessibility within the Sixth Ring Road in Beijing over 15 years. The study also used bivariate correlation analysis to analyze the relationship between urbanization factors and park access. The results showed that the overall park accessibility in both quantity and proximity had increased from 2000 to 2015, but there were still certain areas (percentage) that had limited access to parks. The inequity of distribution in park accessibility had been detected accompanying the rapid increase in park quantity in 2015. Furthermore, the development of urban parks mismatched that of urbanization in terms of urban land increase. The correlation between accessibility changes and population urbanization is not significant. Proper urban green space planning based on the distribution of population density and urban land use is indispensable in avoiding the aggravation of inequity in the process of urban expansion. This study contributes to the assessment of the current park allocation efficiency and helps urban planners and policymakers make prompt adjustments in the rapidly urbanizing process

Driving Mode Selection through SSVEP-Based BCI and Energy Consumption Analysis

Background: The brain–computer interface (BCI) is a highly cross-discipline technology and its successful application in various domains has received increasing attention. However, the BCI-enabled automobile industry is has been comparatively less investigated. In particular, there are currently no studies focusing on brain-controlled driving mode selection. Specifically, different driving modes indicate different driving styles which can be selected according to the road condition or the preference of individual drivers. Methods: In this paper, a steady-state visual-evoked potential (SSVEP)-based driving mode selection system is proposed. Upon this system, drivers can select the intended driving modes by only gazing at the corresponding SSVEP stimuli. A novel EEG processing algorithm named inter-trial distance minimization analysis (ITDMA) is proposed to enhance SSVEP detection. Both offline and real-time experiments were carried out to validate the effectiveness of the proposed system. Conclusion: The results show that a high selection accuracy of up to 92.3% can be realized, although this depends on the specific choice of flickering duration, the number of EEG channels, and the number of training signals. Additionally, energy consumption is investigated in terms of which the proposed brain-controlled system considerably differs from a traditional driving mode selection system, and the main reason is shown to be the existence of a detection error

Combined SFF Patterning and Replica Molding for Microfabrication of Cell-Laden Microfluidic Device

We report on a novel technique using additive manufacturing to fabricate a cell-laden polydimethylsiloxane (PDMS) microfluidic device by SFF processes and replica molding. We demonstrate concept feasibility and present results using single and multiple layer patterns. 3-dimensional channel architecture is achieved by CAD/CAM technology and tuning manufacturing process parameters. Our microfluidic device is fabricated in two stages (1) print negative mold by thermal extrusion of polycaprolactone (PCL) using layer-by-layer precision extrusion deposition then (2) casting PDMS. Cells and matrix are selectively assembled inside microchannels using multi-nozzle printing to demonstrate feasibility of chip as a culture environment. The objective of this work is to fabricate a cell-laden microfluidic device by combined solid freeform patterning and replica molding with direct cell writing into channels. This work has application as a 3D physiological model for in vitro pharmacokinetic study in space environment in preparation for long term manned missions.Mechanical Engineerin