2,070 research outputs found
Weight gain and dietary intake during pregnancy in industrialized countries - a systematic review of observational studies
Background: Gestational weight gain (GWG) above the recently recommended ranges is likely to be related to adverse pregnancy outcomes and therefore a challenge in industrialized countries. Aims: We conducted a systematic review on observational studies in order to gain more evidence on whether diets with lower caloric/protein content or other diets might be associated with lower GWG. Methods: We searched in MEDLINE and EMBASE for observational studies written in English or German reporting associations between diet and GWG in singleton pregnancies of healthy women in industrialized countries. Results: We identified 12 studies which met the inclusion criteria. Five studies suggested significant positive associations between energy intake and GWG, whereas three found no significant association. Further significant positive associations of GWG were reported with respect to protein intake, animal lipids, energy density and a number of different food servings per day, whereas intake of carbohydrates and vegetarian diet were associated with less GWG. Conclusions: We suggest that GWG might be reduced by lower energy intake in pregnancy
Unsupervised hyperspectral data mining and bioimaging by information entropy and self-modeling curve resolution
Unsupervised estimation of the dimensionality of hyperspectral
microspectroscopy datasets containing pure and mixed spectral features, and
extraction of their representative endmember spectra, remains a challenge in
biochemical data mining. We report a new versatile algorithm building on
semi-nonnegativity constrained self-modeling curve resolution and information
entropy, to estimate the quantity of separable biochemical species from
hyperspectral microspectroscopy, and extraction of their representative
spectra. The algorithm is benchmarked with established methods from satellite
remote sensing, spectral unmixing, and clustering. To demonstrate the
widespread applicability of the developed algorithm, we collected hyperspectral
datasets using spontaneous Raman, Coherent Anti-stokes Raman Scattering and
Fourier Transform IR, of seven reference compounds, an oil-in-water emulsion,
and tissue-engineered extracellular matrices on poly-L-lactic acid and porcine
jejunum-derived small intestine submucosa scaffolds seeded with bovine
chondrocytes. We show the potential of the developed algorithm by consolidating
hyperspectral molecular information with sample microstructure, pertinent to
fields ranging from gastrophysics to regenerative medicine
Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets
Objectives: To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard.Design: Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestational age, birth weight, and neonatal follow-up. Small for gestational age was defined as infants weighing less than the 10th centile birth weight for gestational age and sex with the multiethnic, INTERGROWTH-21st birth weight standard. Prevalence of small for gestational age and neonatal mortality risk ratios were calculated and pooled among these datasets at the regional level. With available national level data, prevalence of small for gestational age and population attributable fractions of neonatal mortality attributable to small for gestational age were estimated.Setting: CHERG birth cohorts from 14 population based sites in low and middle income countries.Main outcome measures: In low and middle income countries in the year 2012, the number and proportion of infants born small for gestational age; number and proportion of neonatal deaths attributable to small for gestational age; the number and proportion of neonatal deaths that could be prevented by reducing the prevalence of small for gestational age to 10%.Results: In 2012, an estimated 23.3 million infants (uncertainty range 17.6 to 31.9; 19.3% of live births) were born small for gestational age in low and middle income countries. Among these, 11.2 million (0.8 to 15.8) were term and not low birth weight (≥2500 g), 10.7 million (7.6 to 15.0) were term and low birth weight (\u3c2500 \u3eg) and 1.5 million (0.9 to 2.6) were preterm. In low and middle income countries, an estimated 606 500 (495 000 to 773 000) neonatal deaths were attributable to infants born small for gestational age, 21.9% of all neonatal deaths. The largest burden was in South Asia, where the prevalence was the highest (34%); about 26% of neonatal deaths were attributable to infants born small for gestational age. Reduction of the prevalence of small for gestational age from 19.3% to 10.0% in these countries could reduce neonatal deaths by 9.2% (254 600 neonatal deaths; 164 800 to 449 700).Conclusions: In low and middle income countries, about one in five infants are born small for gestational age, and one in four neonatal deaths are among such infants. Increased efforts are required to improve the quality of care for and survival of these high risk infants in low and middle income countries
Can we avoid high coupling?
It is considered good software design practice to organize source code into modules and to favour within-module connections (cohesion) over between-module connections (coupling), leading to the oft-repeated maxim "low coupling/high cohesion". Prior research into network theory and its application to software systems has found evidence that many important properties in real software systems exhibit approximately scale-free structure, including coupling; researchers have claimed that such scale-free structures are ubiquitous. This implies that high coupling must be unavoidable, statistically speaking, apparently contradicting standard ideas about software structure. We present a model that leads to the simple predictions that approximately scale-free structures ought to arise both for between-module connectivity and overall connectivity, and not as the result of poor design or optimization shortcuts. These predictions are borne out by our large-scale empirical study. Hence we conclude that high coupling is not avoidable--and that this is in fact quite reasonable
Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations
Cognitive mediators of the effect of peer victimization on loneliness
The impact of stress on psychological adjustment may be mediated by cognitive interpretations (i.e., appraisals) of events for individuals. Defining characteristics of loneliness suggest that appraisals of blame, threat, and perceived control may be particularly important in this domain. AIMS: To evaluate the extent to which cognitive appraisals (perceived control, threat, and blame) can mediate the effect of peer victimization on loneliness. SAMPLE: One hundred and ten children (54 boys, 56 girls) aged 8-12 years attending mainstream schools in Scotland. METHOD: Self-report measures of peer victimization, appraisal, and loneliness. RESULTS: Perceived control partially mediated the effects of peer victimization on loneliness, but neither blame nor threat were mediators. All three measures of control were significantly associated with loneliness at the bivariate level, but only perceived control was significant when the appraisals were entered as predictors in a hierarchical multiple linear regression. CONCLUSIONS: The results highlight the importance of research designs assessing multiple categories of appraisal. Furthermore, they suggest that intervention efforts aiming to combat feelings of loneliness within a peer victimization context should address children's appraisals of perceived control
Rich Counter-Examples for Temporal-Epistemic Logic Model Checking
Model checking verifies that a model of a system satisfies a given property,
and otherwise produces a counter-example explaining the violation. The verified
properties are formally expressed in temporal logics. Some temporal logics,
such as CTL, are branching: they allow to express facts about the whole
computation tree of the model, rather than on each single linear computation.
This branching aspect is even more critical when dealing with multi-modal
logics, i.e. logics expressing facts about systems with several transition
relations. A prominent example is CTLK, a logic that reasons about temporal and
epistemic properties of multi-agent systems. In general, model checkers produce
linear counter-examples for failed properties, composed of a single computation
path of the model. But some branching properties are only poorly and partially
explained by a linear counter-example.
This paper proposes richer counter-example structures called tree-like
annotated counter-examples (TLACEs), for properties in Action-Restricted CTL
(ARCTL), an extension of CTL quantifying paths restricted in terms of actions
labeling transitions of the model. These counter-examples have a branching
structure that supports more complete description of property violations.
Elements of these counter-examples are annotated with parts of the property to
give a better understanding of their structure. Visualization and browsing of
these richer counter-examples become a critical issue, as the number of
branches and states can grow exponentially for deeply-nested properties.
This paper formally defines the structure of TLACEs, characterizes adequate
counter-examples w.r.t. models and failed properties, and gives a generation
algorithm for ARCTL properties. It also illustrates the approach with examples
in CTLK, using a reduction of CTLK to ARCTL. The proposed approach has been
implemented, first by extending the NuSMV model checker to generate and export
branching counter-examples, secondly by providing an interactive graphical
interface to visualize and browse them.Comment: In Proceedings IWIGP 2012, arXiv:1202.422
The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation
The lysis of infected cells by disease-causing microorganisms is an efficient but risky strategy for disseminated infection, as it exposes the pathogen to the full repertoire of the host's immune system. Cryptococcus neoformans is a widespread fungal pathogen that causes a fatal meningitis in HIV and other immunocompromised patients. Following intracellular growth, cryptococci are able to escape their host cells by a non-lytic expulsive mechanism that may contribute to the invasion of the central nervous system. Non-lytic escape is also exhibited by some bacterial pathogens and is likely to facilitate long-term avoidance of the host immune system during latency. Here we show that phagosomes containing intracellular cryptococci undergo repeated cycles of actin polymerisation. These actin ‘flashes’ occur in both murine and human macrophages and are dependent on classical WASP-Arp2/3 complex mediated actin filament nucleation. Three dimensional confocal imaging time lapse revealed that such flashes are highly dynamic actin cages that form around the phagosome. Using fluorescent dextran as a phagosome membrane integrity probe, we find that the non-lytic expulsion of Cryptococcus occurs through fusion of the phagosome and plasma membranes and that, prior to expulsion, 95% of phagosomes become permeabilised, an event that is immediately followed by an actin flash. By using pharmacological agents to modulate both actin dynamics and upstream signalling events, we show that flash occurrence is inversely related to cryptococcal expulsion, suggesting that flashes may act to temporarily inhibit expulsion from infected phagocytes. In conclusion, our data reveal the existence of a novel actin-dependent process on phagosomes containing cryptococci that acts as a potential block to expulsion of Cryptococcus and may have significant implications for the dissemination of, and CNS invasion by, this organism.\ud
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Reduction of Birth Weight Among Infants Born to Adolescents: Maternal–Fetal Growth Competition
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72838/1/j.1749-6632.1997.tb48213.x.pd
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