146 research outputs found
Breaking rotational symmetry in two-flavor color superconductors
The color superconductivity under flavor asymmetric conditions relevant to
the compact star phenomenology is studied within the Nambu-Jona-Lasinio model.
We focus on the effect of the deformation of the Fermi surfaces on the pairing
properties and the energy budget of the superconducting state. We find that at
finite flavor asymmetries the color superconducting BCS state is unstable
towards spontaneous quadrupole deformation of the Fermi surfaces of the and
quarks into ellipsoidal form. The ground state of the phase with deformed
Fermi surfaces corresponds to a superposition of prolate and oblate deformed
Fermi ellipsoids of and quarks.Comment: 6 pages, 4 figures. Parameter changes, references added, conclusions
unchange
Black Hole Spin via Continuum Fitting and the Role of Spin in Powering Transient Jets
The spins of ten stellar black holes have been measured using the
continuum-fitting method. These black holes are located in two distinct classes
of X-ray binary systems, one that is persistently X-ray bright and another that
is transient. Both the persistent and transient black holes remain for long
periods in a state where their spectra are dominated by a thermal accretion
disk component. The spin of a black hole of known mass and distance can be
measured by fitting this thermal continuum spectrum to the thin-disk model of
Novikov and Thorne; the key fit parameter is the radius of the inner edge of
the black hole's accretion disk. Strong observational and theoretical evidence
links the inner-disk radius to the radius of the innermost stable circular
orbit, which is trivially related to the dimensionless spin parameter a_* of
the black hole (|a_*| < 1). The ten spins that have so far been measured by
this continuum-fitting method range widely from a_* \approx 0 to a_* > 0.95.
The robustness of the method is demonstrated by the dozens or hundreds of
independent and consistent measurements of spin that have been obtained for
several black holes, and through careful consideration of many sources of
systematic error. Among the results discussed is a dichotomy between the
transient and persistent black holes; the latter have higher spins and larger
masses. Also discussed is recently discovered evidence in the transient sources
for a correlation between the power of ballistic jets and black hole spin.Comment: 30 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher). Changes to Sections 5.2,
6.1 and 7.4. Section 7.4 responds to Russell et al. 2013 (MNRAS, 431, 405)
who find no evidence for a correlation between the power of ballistic jets
and black hole spi
Chiral symmetry breaking, color superconductivity and color neutral quark matter: a variational approach
We investigate the vacuum realignment for chiral symmetry breaking and color
superconductivity at finite density in Nambu-Jona-Lasinio model in a
variational method. The treatment allows us to investigate simultaneous
formation of condensates in quark antiquark as well as in diquark channels. The
methodology involves an explicit construction of a variational ground state and
minimisation of the thermodynamic potential. Color and electric charge
neutrality conditions are imposed through introduction of appropriate chemical
potentials. Color and flavor dependent condensate functions are determined
through minimisation of the thermodynamic potential. The equation of state is
calculated. Simultaneous existence of a mass gap and superconducting gap is
seen in a small window of quark chemical potential within the model when charge
neutrality conditions are not imposed. Enforcing color and electric charge
neutrality conditions gives rise to existence of gapless superconducting modes
depending upon the magnitude of the gap and the difference of the chemical
potentials of the condensing quarks.Comment: 13 pages, 6 figures,to appear in Phys. Rev.
Two lectures on color superconductivity
The first lecture provides an introduction to the physics of color
superconductivity in cold dense quark matter. The main color superconducting
phases are briefly described and their properties are listed. The second
lecture covers recent developments in studies of color superconducting phases
in neutral and beta-equilibrated matter. The properties of gapless color
superconducting phases are discussed.Comment: 56 pages, 9 figures. Minor corrections and references added. Lectures
delivered at the IARD 2004 conference, Saas Fee, Switzerland, June 12 - 19,
2004, and at the Helmholtz International Summer School and Workshop on Hot
points in Astrophysics and Cosmology, JINR, Dubna, Russia, August 2 - 13,
200
Abnormal number of Nambu-Goldstone bosons in the color-asymmetric 2SC phase of an NJL-type model
We consider an extended Nambu--Jona-Lasinio model including both (q \bar q)-
and (qq)-interactions with two light-quark flavors in the presence of a single
(quark density) chemical potential. In the color superconducting phase of the
quark matter the color SU(3) symmetry is spontaneously broken down to SU(2). If
the usual counting of Goldstone bosons would apply, five Nambu-Goldstone (NG)
bosons corresponding to the five broken color generators should appear in the
mass spectrum. Unlike that expectation, we find only three gapless diquark
excitations of quark matter. One of them is an SU(2)-singlet, the remaining two
form an SU(2)-(anti)doublet and have a quadratic dispersion law in the small
momentum limit. These results are in agreement with the Nielsen-Chadha theorem,
according to which NG-bosons in Lorentz-noninvariant systems, having a
quadratic dispersion law, must be counted differently. The origin of the
abnormal number of NG-bosons is shown to be related to a nonvanishing
expectation value of the color charge operator Q_8 reflecting the lack of color
neutrality of the ground state. Finally, by requiring color neutrality, two
massive diquarks are argued to become massless, resulting in a normal number of
five NG-bosons with usual linear dispersion laws.Comment: 13 pages, 4 figures, revtex
The balance of power: accretion and feedback in stellar mass black holes
In this review we discuss the population of stellar-mass black holes in our
galaxy and beyond, which are the extreme endpoints of massive star evolution.
In particular we focus on how we can attempt to balance the available accretion
energy with feedback to the environment via radiation, jets and winds,
considering also possible contributions to the energy balance from black hole
spin and advection. We review quantitatively the methods which are used to
estimate these quantities, regardless of the details of the astrophysics close
to the black hole. Once these methods have been outlined, we work through an
outburst of a black hole X-ray binary system, estimating the flow of mass and
energy through the different accretion rates and states. While we focus on
feedback from stellar mass black holes in X-ray binary systems, we also
consider the applicability of what we have learned to supermassive black holes
in active galactic nuclei. As an important control sample we also review the
coupling between accretion and feedback in neutron stars, and show that it is
very similar to that observed in black holes, which strongly constrains how
much of the astrophysics of feedback can be unique to black holes.Comment: To be published in Haardt et al. Astrophysical Black Holes. Lecture
Notes in Physics. Springer 201
An overview of jets and outflows in stellar mass black holes
In this book chapter, we will briefly review the current empirical
understanding of the relation between accretion state and and outflows in
accreting stellar mass black holes. The focus will be on the empirical
connections between X-ray states and relativistic (`radio') jets, although we
are now also able to draw accretion disc winds into the picture in a systematic
way. We will furthermore consider the latest attempts to measure/order jet
power, and to compare it to other (potentially) measurable quantities, most
importantly black hole spin.Comment: Accepted for publication in Space Science Reviews. Also to appear in
the Space Sciences Series of ISSI - The Physics of Accretion on to Black
Holes (Springer Publisher
Comparison of MRI and VQ-SPECT as a screening test for patients with suspected CTEPH: CHANGE-MRI study design and rationale
The diagnostic strategy for chronic thromboembolic pulmonary hypertension (CTEPH) is composed of two components required for a diagnosis of CTEPH: the presence of chronic pulmonary embolism and an elevated pulmonary artery pressure. The current guidelines require that ventilation–perfusion single-photon emission computed tomography (VQ-SPECT) is used for the first step diagnosis of chronic pulmonary embolism. However, VQ-SPECT exposes patients to ionizing radiation in a radiation sensitive population. The prospective, multicenter, comparative phase III diagnostic trial CTEPH diagnosis Europe - MRI (CHANGE-MRI, ClinicalTrials.gov identifier NCT02791282) aims to demonstrate whether functional lung MRI can serve as an equal rights alternative to VQ-SPECT in a diagnostic strategy for patients with suspected CTEPH. Positive findings are verified with catheter pulmonary angiography or computed tomography pulmonary angiography (gold standard). For comparing the imaging methods, a co-primary endpoint is used. (i) the proportion of patients with positive MRI in the group of patients who have a positive SPECT and gold standard diagnosis for chronic pulmonary embolism and (ii) the proportion of patients with positive MRI in the group of patients with negative SPECT and gold standard. The CHANGE-MRI trial will also investigate the performance of functional lung MRI without i.v. contrast agent as an index test and identify cardiac, hemodynamic, and pulmonary MRI-derived parameters to estimate pulmonary artery pressures and predict 6–12 month survival. Ultimately, this study will provide the necessary evidence for the discussion about changes in the recommendations on the diagnostic approach to CTEPH
Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist
To identify novel D3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a β-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and selectivity. The optimized compound, ML417 (20), potently promotes D3R-mediated β-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs. Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders
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