The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/β-Catenin Coactivators Essential for Intestinal Homeostasis

The leukemia-associated Mllt10/Af10 and its partner the histone methyltransferase Dot1l are identified as Tcf4/β-catenin co-activators and shown to be essential for Wnt-driven endogenous gene expression, intestinal development and homeostasis

Ascese e prazer: Weber vs. Sombart Ascesis and pleasure: Weber vs. Sombart

De que fontes retira o capitalismo moderno a energia para constituir-se e desenvolver-se? A resposta de Weber é mais lembrada do que a de Sombart, que mergulhou num esquecimento quase total. Mas o exame do contraste entre ambos esses mestres da fase heróica da Sociologia alemã no século XX fornece elementos preciosos para entender melhor não só o seu objeto de estudo como também a potência e os limites da análise sociológica que propunham, por ângulos opostos, o ''hedonista" Sombart e o "ascético" Weber.<br>From which sources does modern capitalism get the energy for constituting and developing itself? Weber's answer is more readily remembered than Sombart's, which plunged into almost total oblivion. But an examination of the contrast between these two masters of the heroic phase of German Sociology in the 20th century gives precious elements for understanding not only the subject of study but also the power and the limits of the sociological analysis which was proposed from opposed angles by the "hedonist" Sombart and the "ascetic" Max Weber