Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children.

Perioperative pain in children can be effectively managed with systemic opioids, but addition of paracetamol or nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce opioid requirements and potentially improve analgesia and/or reduce adverse effects

Sea lice exposure to non-lethal levels of emamectin benzoate after treatments: a potential risk factor for drug resistance

The avermectin derivative emamectin benzoate (EMB) has been widely used by salmon industries around the world to control sea lice infestations. Resistance to this anti-parasitic drug is also commonly reported in these industries. The objective of this study was to quantify the number of sea lice potentially exposed to sub-lethal concentrations of EMB while fish clear the drug after treatments. We assessed juvenile sea lice abundance after 38 EMB treatments on six Atlantic salmon farms, in a small archipelago in British Colombia, Canada, between 2007 and 2018. We fitted a standard EMB pharmacokinetic curve to determine the time when fish treated with this product would have EMB tissue concentrations below the recommended target therapeutic level. During the study, we estimated that for each sea lice treatment there was, on average, an abundance of 0.12 juvenile sea lice per fish during the time period when the concentrations of EMB would have been lower than 60ppb, the recommended therapeutic treatment level for sea lice. The findings from this study on metaphylactic anti-parasitic treatments identify a potential driver for drug resistance in sea lice that should be further explored

Sea lice exposure to non-lethal levels of emamectin benzoate after treatments: a potential risk factor for drug resistance

The avermectin derivative emamectin benzoate (EMB) has been widely used by salmon industries around the world to control sea lice infestations. Resistance to this anti-parasitic drug is also commonly reported in these industries. The objective of this study was to quantify the number of sea lice potentially exposed to sub-lethal concentrations of EMB while fish clear the drug after treatments. We assessed juvenile sea lice abundance after 38 EMB treatments on six Atlantic salmon farms, in a small archipelago in British Colombia, Canada, between 2007 and 2018. We fitted a standard EMB pharmacokinetic curve to determine the time when fish treated with this product would have EMB tissue concentrations below the recommended target therapeutic level. During the study, we estimated that for each sea lice treatment there was, on average, an abundance of 0.12 juvenile sea lice per fish during the time period when the concentrations of EMB would have been lower than 60ppb, the recommended therapeutic treatment level for sea lice. The findings from this study on metaphylactic anti-parasitic treatments identify a potential driver for drug resistance in sea lice that should be further explored

The Re-examined Life

The Re-examined Life is an interdisciplinary exhibition of contemplative and interactive artworks that use the expectations of conventional belief systems to question widespread perceptions and value judgments of our current culture. Each piece is created collaboratively, beginning with dialogical investigations that attempt to clarify what it means to be-in-the-world. These inquiries take us beyond accepted models of social organization and lead us to question and uncover the illusions of our current systems. The result is an exhibition of five modules: a Social Bank, an Identity Centre, Reflective Sculptures, Community Tables and a Listening Lounge. Each module reimagines familiar objects and settings, revealing the unstable nature of human knowledge. Visitors are encouraged to interact and openly reflect on how the authority of physical space and social systems shape who we are in the world

The Re-examined Life

The Re-examined Life is an interdisciplinary exhibition of contemplative and interactive artworks that use the expectations of conventional belief systems to question widespread perceptions and value judgments of our current culture. Each piece is created collaboratively, beginning with dialogical investigations that attempt to clarify what it means to be-in-the-world. These inquiries take us beyond accepted models of social organization and lead us to question and uncover the illusions of our current systems. The result is an exhibition of five modules: a Social Bank, an Identity Centre, Reflective Sculptures, Community Tables and a Listening Lounge. Each module reimagines familiar objects and settings, revealing the unstable nature of human knowledge. Visitors are encouraged to interact and openly reflect on how the authority of physical space and social systems shape who we are in the world