NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

The formation of enduring internal representation of sensory information demands, in many cases, convergence in time and space of two different stimuli. The first conveys the sensory input, mediated via fast neurotransmission. The second conveys the meaning of the input, hypothesized to be mediated via slow neurotransmission. We tested the biochemical conditions and feasibility for fast (NMDA) and slow (dopamine) neurotransmission to converge on the Mitogen Activated Protein Kinase signaling pathways, crucial in several forms of synaptic plasticity, and recorded its effects upon synaptic transmission. We detected differing kinetics of ERK2 activation and synaptic strength changes in the CA1 for low and high doses of neurotransmitters in hippocampal slices. Moreover, when weak fast and slow inputs are given together, they converge on ERK2, but not on p38 or JNK, and induce strong short-term synaptic depression. Surprisingly, pharmacological analysis revealed that a probable site of such convergence is the NMDA receptor itself, suggesting it serves as a detector and integrator of fast and slow neurotransmission in the mature mammalian brain, as revealed by ERK2 activation and synaptic function

ExoClock Project. II. A Large-scale Integrated Study with 180 Updated Exoplanet Ephemerides

International audienceThe ExoClock project is an inclusive, integrated, and interactive platform that was developed to monitor the ephemerides of the Ariel targets to increase the mission efficiency. The project makes the best use of all available resources, i.e., observations from ground telescopes, midtime values from the literature, and finally, observations from space instruments. Currently, the ExoClock network includes 280 participants with telescopes capable of observing 85% of the currently known Ariel candidate targets. This work includes the results of ~1600 observations obtained up to 2020 December 31 from the ExoClock network. These data in combination with ~2350 midtime values collected from the literature are used to update the ephemerides of 180 planets. The analysis shows that 40% of the updated ephemerides will have an impact on future scheduling as either they have a significantly improved precision or they have revealed biases in the old ephemerides. With the new observations, the observing coverage and rate for half of the planets in the sample has been doubled or more. Finally, from a population perspective, we identify that the differences in the 2028 predictions between the old and the new ephemerides have an STD that is double what is expected from Gaussian uncertainties. These findings have implications for planning future observations, where we will need to account for drifts potentially greater than the prediction uncertainties. The updated ephemerides are open and accessible to the wider exoplanet community both from our Open Science Framework repository and our website