9 research outputs found
Gore et al. reply
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/11/2007
- Field of study
10.1038/nature06315Nature4507167E2-E4NATU
Staging Laparoscopy Not Only Saves Patients an Incision, But May Also Help Them Live Longer
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cost-effectiveness of diagnostic laparoscopy for assessing resectability in pancreatic and periampullary cancer
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The zebrafish dorsal axis is apparent at the four-cell stage
- Author
- Albert Cheong
- Aniket V. Gore
- AV Gore
- B Feldman
- B Feldman
- B Feng
- C Kelly
- C Weaver
- CE Erter
- DG Higgins
- Eric S. Weinberg
- F Muller
- J Heasman
- J Oppenheimer
- JD Lambert
- K Sampath
- KA Helde
- Karuna Sampath
- M Zernicka-Goetz
- MR Rebagliati
- Patrick C. Gilligan
- Q Tao
- RT Moon
- S Abdelilah
- S Jesuthasan
- SA Holley
- Shingo Maegawa
- SL Bullock
- SL Klein
- ST Dougan
- SY Sokol
- T Mizuno
- V Riechmann
- Y Kishimoto
- Y Yamanaka
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/12/2005
- Field of study
10.1038/nature04184Nature43870701030-1035NATU
A study of mental stress and antioxidant profile in the Assamese-speaking diabetic population of Assam, India
- Author
- A Mitra
- Abani Kumar Choudhury
- AJ White
- AK Sinha
- AM Concepciâon
- AM Zafary
- American Diabetes Association
- C Grimm
- C Lloyd
- CM Martin
- DB Goldston
- ES Ford
- EZ Fisman
- GJ Boersma
- H Britta
- H Ohkawa
- Indrani Barman
- International Diabetes Federation
- JK Ryu
- K Esposito
- K Gregory
- K Kishida
- Karuna Barman
- KK Rocha
- KM Eydoxia
- KS Arunpreet
- LE Egede
- M Camilleri
- Mamta Mishra Purohit
- Monjoy Kumar Choudhury
- MR Ann
- Murchana Choudhury
- NH Farag
- P Maurizio
- R Alam
- SL Marklund
- SM Grundy
- ST Omaye
- TH Diniz
- V Vladislav
- W Colin
- YPS Balhara
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
- Author
- A Chattopadhyay
- A Chattopadhyay
- B Smith
- BJ Van Lenten
- BJ Van Lenten
- C Danilo
- C Mineo
- CT Guy
- D Meriwether
- D Meriwether
- ER Nelson
- F Slebe
- F Su
- F Su
- G Llaverias
- G Llaverias
- H Jafri
- H Ni
- H-L Huang
- HA Hirsch
- I Burkard
- I Delimaris
- J Ferlay
- J Liu
- JC EscolĂ -Gil
- JC EscolĂ -Gil
- JC EscolĂ -Gil
- JS Troutt
- L Baila-Rueda
- L CedĂł
- M Khaidakov
- M Khaidakov
- M Liang
- M Murph
- M Navab
- M Navab
- M Reverter
- M Umetani
- M Zamanian-Daryoush
- N Alikhani
- N Rotllan
- Q Wu
- R Karuna
- R Silvennoinen
- RD Cardiff
- Rvan Haperen
- S Yang
- ST Reddy
- T Wada
- VG Flote
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Review of preventative HIV vaccine clinical trials in South Africa
- Author
- BO Ondondo
- BS Peters
- C Zambonelli
- CK Cunningham
- D Ndwandwe
- DH Barouch
- E Choi
- E Mohr
- E Vardas
- Erica M. Lazarus
- ES Gray
- F Laher
- Fatima Laher
- G Churchyard
- G Gray
- GE Gray
- GE Gray
- GE Gray
- GJ Churchyard
- Glenda E. Gray
- I Mikell
- I Valdés
- J Hemelaar
- J MoĂŻsi
- J Vekemans
- JF Scheid
- K Ahmed
- KL Hopkins
- L Li
- L-G Bekker
- Linda-Gail Bekker
- LR Baden
- M Saxena
- M Wecker
- MA Liu
- MC Hosseinipour
- MHV Van Regenmortel
- MHV Van Regenmortel
- MHV Van Regenmortel
- N Bbosa
- Nigel Garrett
- O Nicholson
- P Adepoju
- P Pitisuttithum
- PB Gilbert
- S Auclair
- S Lu
- S Mahomed
- S Moretti
- S Rerks-Ngarm
- SB Joseph
- SM Hammer
- SP Buchbinder
- ST Karuna
- TJ Tucker
- W Fischer
- X Shen
- Z Moodie
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Enhanced infection prophylaxis reduces mortality in severely immunosuppressed HIV-infected adults and older children initiating antiretroviral therapy in Kenya, Malawi, Uganda and Zimbabwe: the REALITY trial
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- Abach J
- Abdallah J
- Abdallah S
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- Aberle-Grasse J
- Abimiku A
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- Abongomera G
- Aboud M
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- Abramovitz D
- Abrams E
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- Abravaya K
- Abreu L
- Achra A
- Adera F
- Adetokunboh O
- Adeyemi O
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- Adipo T
- Affolabi D
- Agegnehu D
- Agius P
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- Apollon A
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- Zablotska I
- Zablotska I
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- Zandamela A
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- Zerbe A
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- Zhang F
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- Zhanpeisova A
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- Publication venue
- 'International AIDS Society'
- Publication date
- 01/01/2016
- Field of study
Meeting abstract FRAB0101LB from 21st International AIDS Conference 18â22 July 2016, Durban, South Africa.
Introduction: Mortality from infections is high in the first 6 months of antiretroviral therapy (ART) among HIVâinfected adults and children with advanced disease in subâSaharan Africa. Whether an enhanced package of infection prophylaxis at ART initiation would reduce mortality is unknown.
Methods:
The REALITY 2Ă2Ă2 factorial openâlabel trial (ISRCTN43622374) randomized ARTânaĂŻve HIVâinfected adults and children >5 years with CD4 <100 cells/mm3. This randomization compared initiating ART with enhanced prophylaxis (continuous cotrimoxazole plus 12 weeks isoniazid/pyridoxine (antiâtuberculosis) and fluconazole (antiâcryptococcal/candida), 5 days azithromycin (antiâbacterial/protozoal) and singleâdose albendazole (antiâhelminth)), versus standardâofâcare cotrimoxazole. Isoniazid/pyridoxine/cotrimoxazole was formulated as a scored fixedâdose combination. Two other randomizations investigated 12âweek adjunctive raltegravir or supplementary food. The primary endpoint was 24âweek mortality.
Results:
1805 eligible adults (n = 1733; 96.0%) and children/adolescents (n = 72; 4.0%) (median 36 years; 53.2% male) were randomized to enhanced (n = 906) or standard prophylaxis (n = 899) and followed for 48 weeks (3.8% lossâtoâfollowâup). Median baseline CD4 was 36 cells/mm3 (IQR: 16â62) but 47.3% were WHO Stage 1/2. 80 (8.9%) enhanced versus 108(12.2%) standard prophylaxis died before 24 weeks (adjusted hazard ratio (aHR) = 0.73 (95% CI: 0.54â0.97) p = 0.03; Figure 1) and 98(11.0%) versus 127(14.4%) respectively died before 48 weeks (aHR = 0.75 (0.58â0.98) p = 0.04), with no evidence of interaction with the two other randomizations (p > 0.8). Enhanced prophylaxis significantly reduced incidence of tuberculosis (p = 0.02), cryptococcal disease (p = 0.01), oral/oesophageal candidiasis (p = 0.02), deaths of unknown cause (p = 0.02) and (marginally) hospitalisations (p = 0.06) but not presumed severe bacterial infections (p = 0.38). Serious and grade 4 adverse events were marginally less common with enhanced prophylaxis (p = 0.06). CD4 increases and VL suppression were similar between groups (p > 0.2).
Conclusions:
Enhanced infection prophylaxis at ART initiation reduces early mortality by 25% among HIVâinfected adults and children with advanced disease. The pill burden did not adversely affect VL suppression. Policy makers should consider adopting and implementing this lowâcost broad infection prevention package which could save 3.3 lives for every 100 individuals treated
The Modern Art of Identification of Natural Substances in Whole Plants
- Author
- A Antonopoulos
- A Berthod
- A Cifuentes
- A Crecelius
- A Crego
- A Farina
- A Gentili
- A Gentili
- A Hazotte
- A Marston
- A Matsubara
- A Pruvost
- A Pukalskas
- A Salvador
- A Sides
- A Stolyhwo
- A Subagio
- A Toribio
- A Toribio
- AE Karatapanis
- AGM Leijdekkers
- AI Calderon
- AJ Blasco
- AJ Jenkins
- AJ Martin
- AM Moricz
- AM Moricz
- B Benova
- B Claude
- B Herbreteau
- B Herbreteau
- B Marcato
- B Pongnaravane
- B Rhourri-Frih
- B Rhourri-Frih
- BE Richter
- C Bicchi
- C Grunwald
- C Liu
- C Longo
- C Munoz-Gonzalez
- C Nunes
- C Remoroza
- C Seger
- C Turne
- C Viron
- CC Tangney
- CH Chan
- CS Eskilsson
- CW Jiang
- D Asa
- D Gutzeit
- D Lubda
- D Medici De
- DR Heldman
- DR Stoll
- E Boselli
- E Cicchetti
- E Hoffman De
- E Hurtado-Fernandez
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- E Uquiche
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- F Augusto
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- F Bertoncini
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- F Gritti
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- HA Verhoeven
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- I Lee
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- K Ashraf
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- KD Altria
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- L Mondello
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- L Novakova
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- LC Nogueira
- LJ Wang
- LK Ng
- LQ Jiang
- LT Taylor
- M Adam
- M Biesaga
- M Co
- M Dreux
- M Dreux
- M Du
- M Gao
- M Garcia-Marino
- M Gomez-Romero
- M Herrero
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- M Lisa
- M Lopez
- M Makino
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- M Person de
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- M Scampicchio
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- M Soni
- M Vaher
- M Valcarcel
- M Waksmundzka-Hainos
- MA Olszewska
- MA Rather
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- MAN Ramirez-Coronel
- MB Hossain
- ME Lucchesi
- ME Lucchesi
- ME Seker
- MJ Alfaro
- MJ Cho
- MJ Hilhorst
- MJ Lerma-Garcia
- MK Balz
- MS Goncalves
- MS Maoela
- MZ Ozel
- MZ Ozel
- N Bryson
- N Sanchez-Avila
- N Vervoort
- N Volpi
- NC Megoulas
- O Nunez
- O Shirota
- O Sticher
- P Agrafiotou
- P Cesla
- P Chaimbault
- P Dugo
- P Fellows
- P Garcia-Salas
- P Hommerson
- P Korytar
- P Manninen
- P Manzano
- P Poukensrenwart
- P Ramirez
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- T Michel
- T Michel
- T Seppanen-Laakso
- T Storm
- TH Kim
- TL Yue
- TM Annesley
- U Justesen
- UK Sharma
- V Illes
- V Jerkovic
- V Kumar
- V Larroque
- V Mandal
- V Srivastava
- VV Tolstikov
- W Bertsch
- W Mulbry
- W Murayama
- W Wichitnithad
- WA Konig
- WM Coleman
- WM Stoggl
- X Zhao
- Y Hirahara
- Y Ito
- Y Yu
- YB Lu
- YT Tung
- YW Chang
- Z Hromadkova
- ZG Hao
- ZL Chen
- ZL Chen
- ZS Zhang
- ZX Lou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study