Thermal simulation outputs: exploring the concept of patterns in design decision-making

This paper describes the ongoing development of a building performance simulation (BPS) knowledge management scheme for design decision-making. This knowledge management scheme is developed with reference to the patterns of Christopher Alexander and colleagues, which describe commonly recurring abstract problems in architectural design together with successful abstract solutions. As such they form a ‘repository of knowledge’ on architectural design. Patterns have been used in other fields such as software engineering where they also aim at capturing expert knowledge, and their potential to do the same for BPS is explored here. Decision support using simulation is introduced and the concept of patterns described. A pattern structure is developed and some examples given. Interviews with architectural practices investigated whether patterns could support design processes, and the further development of the concept is discussed

Thermal simulation software outputs: patterns for decision making

This paper describes a structure that enables simulation software developers and building designers to produce thermal simulation results meaningful to design decision making. The structure is based on the development of 'patterns' in which analysis processes are applied to thermal simulation outputs to produce relevant information to inform design actions and decisions. A discussion is made on how the patterns can be developed and examples illustrate the suggested development process and generation of simulation outputs. The patterns are intended to bridge the gap between the needs of the designer for useful design oriented software, and the needs of the software developer for technical information on exactly what is required by the user

Placing user needs at the centre of building performance simulation tool development: Using ‘designer personas’ to assess existing BPS tools

This paper explores the development of ‘building designer personas’ to illustrate how Building Performance Simulation (BPS) can engage with Human Computer Interaction (HCI) knowledge and methods to place its users at the centre of development of new tools. It explains this concept and sets up the fundamentals to develop it further based on previous work on meaningful information for design decision making (Bleil de Souza and Tucker 2014 and 2015). An example of a building designer ‘provisional persona’ in a specific scenario is developed in detail. This example is then used to assess how current BPS tools satisfy this user’s needs and to identify what is missing from BPS development through not carefully considering those needs. This concept can be applied to different types of BPS users and this paper briefly mentions how to explore it in future work

Of mice and men: opposing effects of nicotinamide riboside on skeletal muscle physiology at rest and during exercise.

Funder: European Union's Horizon 202

Placing User Needs at the Centre of Building Performance Simulation: Transferring Knowledge from Human Computer Interaction

This paper reviews and explores some principles and theories of Human-Computer Interaction (HCI) and the related field of Interaction Design in relation to Building Performance Simulation (BPS). HCI seeks to make computer systems and software more useable and more attractive to its users. The main focus of the paper is on the interaction between user and computer system and how interaction could facilitate the knowledge transfer of BPS procedures and processes from experts to non-experts. The paper discusses users and their tasks, designing for interaction, and the level of control different users might have over BPS. Design patterns are proposed as a means of interaction between user and computer system. The aim of the paper is to provide a platform for a future discussion on the extent to which BPS has engaged with HCI practices and principles, and the possibilities HCI holds for the further development of BPS. A number of research directions are identified

The influence of maternal and infant nutrition on cardiometabolic traits: novel findings and future research directions from four Canadian birth cohort studies

A mother's nutritional choices while pregnant may have a great influence on her baby's development in the womb and during infancy. There is evidence that what a mother eats during pregnancy interacts with her genes to affect her child's susceptibility to poor health outcomes including childhood obesity, pre-diabetes, allergy and asthma. Furthermore, after what an infant eats can change his or her intestinal bacteria, which can further influence the development of these poor outcomes. In the present paper, we review the importance of birth cohorts, the formation and early findings from a multi-ethnic birth cohort alliance in Canada and summarise our future research directions for this birth cohort alliance. We summarise a method for harmonising collection and analysis of self-reported dietary data across multiple cohorts and provide examples of how this birth cohort alliance has contributed to our understanding of gestational diabetes risk; ethnic and diet-influences differences in the healthy infant microbiome; and the interplay between diet, ethnicity and birth weight. Ongoing work in this birth cohort alliance will focus on the use of metabolomic profiling to measure dietary intake, discovery of unique diet–gene and diet–epigenome interactions, and qualitative interviews with families of children at risk of metabolic syndrome. Our findings to-date and future areas of research will advance the evidence base that informs dietary guidelines in pregnancy, infancy and childhood, and will be relevant to diverse and high-risk populations of Canada and other high-income countries

A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - the Diet and Genetic Intervention (DIGEST) Pilot study

Background Risk of cardiovascular disease (CVD) can be increased by single-nucleotide polymorphisms (SNPs) in the 9p21 region of the genome. However, observational studies have shown that the deleterious effect of 9p21 SNPs on CVD might be offset by consuming a diet rich in fresh fruits and vegetables. This association may be driven by diet-influenced modifications in epigenetic and gene expression profiles. In this pilot study, we aimed to: i. test the feasibility of provision of a ‘Prudent’ and ‘Western’ diet outside of a specialized clinic, ii. assess the impact of each diet on cardiovascular risk factors. Methods A single centre, parallel two-arm, pilot randomized controlled trial (RCT) with food provision was conducted in a university teaching hospital outpatient clinic (McMaster university, Hamilton, ON, Canada). The aim was to recruit 80 participants, which allowed for a 10 % dropout. The actual study consisted of 84 apparently healthy participants (69 % women, 18 to 77 years) at low cardiovascular risk. Participants were randomly assigned to follow one of two weight-maintaining diets: ‘Prudent’ or ‘Western’ for 2-weeks. The Prudent diet provided 92 % of provided food consumed). The Prudent diet was 48 % more palatable than the Western diet (P < 0.05). Participants receiving the Prudent diet showed a trend toward reduced systolic (-4 mmHg; P = 0.10) and diastolic (-3 mmHg; P = 0.07) blood pressure, and total cholesterol (-0.24 mmol/L; P = 0.08), compared to individuals receiving the Western diet. Data collection from all randomized participants was completed within 18 months. Conclusions Recruitment, and retention of apparently healthy, normotensive adults into a feeding study for a 2-week duration is feasible outside of specialized dietary clinic, and modest diet-related changes in biomarkers begin to appear after two weeks

Structural Changes of the Paraflagellar Rod during Flagellar Beating in Trypanosoma cruzi

, the agent of Chagas disease, is a protozoan member of the Kinetoplastidae family characterized for the presence of specific and unique structures that are involved in different cell activities. One of them is the paraflagellar rod (PFR), a complex array of filaments connected to the flagellar axoneme. Although the function played by the PFR is not well established, it has been shown that silencing of the synthesis of its major proteins by either knockout of RNAi impairs and/or modifies the flagellar motility.Here, we present results obtained by atomic force microscopy (AFM) and transmission electron microscopy (TEM) of replicas of quick-frozen, freeze-fractured, deep-etched and rotary-replicated cells to obtain detailed information of the PFR structures in regions of the flagellum in straight and in bent state. The images obtained show that the PFR is not a fixed and static structure. The pattern of organization of the PFR filament network differs between regions of the flagellum in a straight state and those in a bent state. Measurements of the distances between the PFR filaments and the filaments that connect the PFR to the axoneme as well as of the angles between the intercrossed filaments supported this idea.Graphic computation based on the information obtained allowed the proposal of an animated model for the PFR structure during flagellar beating and provided a new way of observing PFR filaments during flagellar beating