Talk piece with Ed de Oliveira, an associate in the consulting firm Barton & G

Talk piece with Ed de Oliveira, an associate in the consulting firm Barton & Gingold, who hosts biweekly brown bag luncheons in Portland for people who want to practice speaking Spanish

Benefits of flexible prioritization in working memory can arise without costs

Most recent models conceptualize working memory (WM) as a continuous resource, divided up according to task demands. When an increasing number of items need to be remembered, each item receives a smaller chunk of the memory resource. These models predict that the allocation of attention to high-priority WM items during the retention interval should be a zero-sum game: improvements in remembering cued items come at the expense of uncued items because resources are dynamically transferred from uncued to cued representations. The current study provides empirical data challenging this model. Four precision retrocueing WM experiments assessed cued and uncued items on every trial. This permitted a test for trade-off of the memory resource. We found no evidence for trade-offs in memory across trials. Moreover, robust improvements in WM performance for cued items came at little or no cost to uncued items that were probed afterwards, thereby increasing the net capacity of WM relative to neutral cueing conditions. An alternative mechanism of prioritization proposes that cued items are transferred into a privileged state within a response-gating bottleneck, in which an item uniquely controls upcoming behavior. We found evidence consistent with this alternative. When an uncued item was probed first, report of its orientation was biased away from the cued orientation to be subsequently reported. We interpret this bias as competition for behavioral control in the output-driving bottleneck. Other items in WM did not bias each other, making this result difficult to explain with a shared resource model

GoFit Erasmus project: a transdisciplinary approach for exercise, health and tourism

GoFit (Go Functional Improvement and Tourism) program was conceived as an educational tool for experts in sport and exercise science. Its goal is to teach experts important skills to support tourists on the development of healthy habits when they are less busy and more open to suggestions over adapting new healthier habits. The GO Functional Improvement & Tourism (GO FIT) project addresses the gap in learning programs between HEI’s exercise and health experts with both educational and clinical expertise in collaboration with tourism manager’s specialists. The authors discuss the way the GO FIT project is conceived and designed so as to develop a new learning program, by using Information and Communication Technologies (ICTs) through the development of a web platform and a multimedia application. This transdisciplinary approach for exercise, health and tourism experts aims to achieve relevant and high quality skills and competences in designing the appropriate program for tourists and helping them to adopt a new healthy lifestyle

Preclinical pharmacology of a lipophenol in a mouse model of light-induced retinopathy

International audienceEnvironmental light has deleterious effects on the outer retina in human retinopathies, such as ABCA4-related Stargardt's disease and dry age-related macular degeneration. These effects involve carbonyl and oxidative stress, which contribute to retinal cell death and vision loss. Here, we used an albino Abca4 −/− mouse model, the outer retina of which shows susceptibility to acute photodamage, to test the protective efficacy of a new polyunsaturated fatty acid lipophenol derivative. Anatomical and functional analyses demonstrated that a single intravenous injection of isopropyl-phloroglucinol-DHA, termed IP-DHA, dose-dependently decreased light-induced photoreceptor degeneration and preserved visual sensitivity. This protective effect persisted for 3 months. IP-DHA did not affect the kinetics of the visual cycle in vivo or the activity of the RPE65 isomerase in vitro. Moreover, IP-DHA administered by oral gavage showed significant protection of photoreceptors against acute light damage. In conclusion, short-term tests in Abca4-deficient mice, following single-dose administration and light exposure, identify IP-DHA as a therapeutic agent for the prevention of retinal degeneration