3,840 research outputs found
Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion. However, it is unknown how CaR activation improves β-cell function. Methods: Immunocytochemistry and western blotting confirmed the expression of CaR in MIN6 β-cell line. The calcimimetic R568 (1µM) was used to increase the affinity of the CaR and specifically activate the receptor at a physiologically appropriate extracellular calcium concentration. Incorporation of 5-bromo-2’-deoxyuridine (BrdU) was used to measure cell proliferation, whilst changes in non-nutrient-evoked cytosolic calcium were assessed using fura-2-microfluorimetry. AFM-single-cell-force spectroscopy related CaR-evoked changes in epithelial (E)-cadherin expression to improved functional tethering between coupled cells. Results: Activation of the CaR over 48hr doubled the expression of E-cadherin (206±41%) and increased L-type voltage-dependent calcium channel expression by 70% compared to control. These changes produced a 30% increase in cell-cell tethering and elevated the basal-to-peak amplitude of ATP (50µM) and tolbutamide (100µM)-evoked changes in cytosolic calcium. Activation of the receptor also increased PD98059 (1-100µM) and SU1498 (1-100µM)-dependent β-cell proliferation. Conclusion: Our data suggest that activation of the CaR increases E-cadherin mediated functional tethering between β-cells and increases expression of L-type VDCC and secretagogue-evoked changes in [Ca2+]i. These findings could explain how local changes in calcium, co-released with insulin, activate the CaR on neighbouring cells to help ensure efficient and appropriate secretory function
FISHING SKILL IN DEVELOPING COUNTRY FISHERIES: THE KEDAH, MALAYSIA TRAWL FISHERY
Fishing skill is perceived to play a crucial role in catching fish. The question arises for fishery managers as to whether or not there are observable and measurable attributes of the skipper or vessel that can be monitored and regulated to account for skipper skill and, hence, this source of fishing capacity. Equating technical efficiency with skipper skill, this paper evaluates technical efficiency and skipper skill in the Kedah, Malaysia, trawl fishery to address this issue.Resource /Energy Economics and Policy,
The Origin of [O II] Emission in Recently Quenched Active Galaxy Nucleus Hosts
We have employed emission-line diagnostics derived from DEIMOS and NIRSPEC spectroscopy to determine the origin of the [O II] emission line observed in six active galactic nucleus (AGN) hosts at z ~ 0.9. These galaxies are a subsample of AGN hosts detected in the Cl1604 supercluster that exhibit strong Balmer absorption lines in their spectra and appear to be in a post-starburst or post-quenched phase, if not for their [O II] emission. Examining the flux ratio of the [N II] to Hα lines, we find that in five of the six hosts the dominant source of ionizing flux is AGN continuum emission. Furthermore, we find that four of the six galaxies have over twice the [O II] line luminosity that could be generated by star formation alone given their Hα line luminosities. This strongly suggests that AGN-excited narrow-line emission is contaminating the [O II] line flux. A comparison of star formation rates calculated from extinction-corrected [O II] and Hα line luminosities indicates that the former yields a five-fold overestimate of the current activity in these galaxies. Our findings reveal the [O II] line to be a poor indicator of star formation activity in a majority of these moderate-luminosity Seyferts. This result bolsters our previous findings that an increased fraction of AGN at high redshifts is hosted by galaxies in a post-starburst phase. The relatively high fraction of AGN hosts in the Cl1604 supercluster that show signs of recently truncated star formation activity may suggest that AGN feedback plays an increasingly important role in suppressing ongoing activity in large-scale structures at high redshift
Slip-velocity of large neutrally-buoyant particles in turbulent flows
We discuss possible definitions for a stochastic slip velocity that describes
the relative motion between large particles and a turbulent flow. This
definition is necessary because the slip velocity used in the standard drag
model fails when particle size falls within the inertial subrange of ambient
turbulence. We propose two definitions, selected in part due to their
simplicity: they do not require filtration of the fluid phase velocity field,
nor do they require the construction of conditional averages on particle
locations. A key benefit of this simplicity is that the stochastic slip
velocity proposed here can be calculated equally well for laboratory, field,
and numerical experiments. The stochastic slip velocity allows the definition
of a Reynolds number that should indicate whether large particles in turbulent
flow behave (a) as passive tracers; (b) as a linear filter of the velocity
field; or (c) as a nonlinear filter to the velocity field. We calculate the
value of stochastic slip for ellipsoidal and spherical particles (the size of
the Taylor microscale) measured in laboratory homogeneous isotropic turbulence.
The resulting Reynolds number is significantly higher than 1 for both particle
shapes, and velocity statistics show that particle motion is a complex
non-linear function of the fluid velocity. We further investigate the nonlinear
relationship by comparing the probability distribution of fluctuating
velocities for particle and fluid phases
Spin anisotropy of the resonance in superconducting FeSe0.5Te0.5
We have used polarized-neutron inelastic scattering to resolve the spin
fluctuations in superconducting FeSe0.5Te0.5 into components parallel and
perpendicular to the layers. A spin resonance at an energy of 6.5 meV is
observed to develop below T_c in both fluctuation components. The resonance
peak is anisotropic, with the in-plane component slightly larger than the
out-of-plane component. Away from the resonance peak the magnetic fluctuations
are isotropic in the energy range studied. The results are consistent with a
dominant singlet pairing state with s^{\pm} symmetry, with a possible minority
component of different symmetry.Comment: 5 pages, 4 figure
The Assembly of the Red Sequence at z ~ 1: The Color and Spectral Properties of Galaxies in the Cl1604 Supercluster
We investigate the properties of the 525 spectroscopically confirmed members of the Cl1604 supercluster at z ~ 0.9 as part of the Observations of Redshift Evolution in Large Scale Environments survey. In particular, we focus on the photometric, stellar mass, morphological, and spectral properties of the 305 member galaxies of the eight clusters and groups that comprise the Cl1604 supercluster. Using an extensive Keck Low-Resolution Imaging Spectrometer (LRIS)/DEep Imaging Multi-Object Spectrograph (DEIMOS) spectroscopic database in conjunction with ten-band ground-based, Spitzer, and Hubble Space Telescope imaging, we investigate the buildup of the red sequence in groups and clusters at high redshift. Nearly all of the brightest and most massive red-sequence galaxies present in the supercluster environment are found to lie within the bounds of the cluster and group systems, with a surprisingly large number of such galaxies present in low-mass group systems. Despite the prevalence of these red-sequence galaxies, we find that the average cluster galaxy has a spectrum indicative of a star-forming galaxy, with a star formation rate between those of z ~ 1 field galaxies and moderate-redshift cluster galaxies. The average group galaxy is even more active, exhibiting spectral properties indicative of a starburst. The presence of massive, red galaxies and the high fraction of starbursting galaxies present in the group environment suggest that significant processing is occurring in group environments at z ~ 1 and earlier. There is a deficit of low-luminosity red-sequence galaxies in all Cl1604 clusters and groups, suggesting that such galaxies transition to the red sequence at later times. Extremely massive (~10^(12)M_☉) red-sequence galaxies routinely observed in rich clusters at z ~ 0 are also absent from the Cl1604 clusters and groups. We suggest that such galaxies form at later times through merging processes. There are significant populations of transition galaxies at intermediate stellar masses (log(M_*)=10.25-10.75) present in the group and cluster environments, suggesting that this range is important for the buildup of the red-sequence mass function at z ~ 1. Through a comparison of the transitional populations present in the Cl1604 cluster and group systems, we find evidence that massive blue-cloud galaxies are quenched earliest in the most dynamically relaxed systems and at progressively later times in dynamically unrelaxed systems
Spin Waves in Striped Phases
In many antiferromagnetic, quasi-two-dimensional materials, doping with holes
leads to "stripe" phases, in which the holes congregate along antiphase domain
walls in the otherwise antiferromagnetic texture. Using a suitably parametrized
two-dimensional Heisenberg model on a square lattice, we study the spin wave
spectra of well-ordered spin stripes, comparing bond-centered antiphase domain
walls to site-centered antiphase domain walls for a range of spacings between
the stripes and for stripes both aligned with the lattice ("vertical") and
oriented along the diagonals of the lattice ("diagonal"). Our results establish
that there are qualitative differences between the expected neutron scattering
responses for the bond-centered and site-centered cases. In particular,
bond-centered stripes of odd spacing generically exhibit more elastic peaks
than their site-centered counterparts. For inelastic scattering, we find that
bond-centered stripes produce more spin wave bands than site-centered stripes
of the same spacing and that bond-centered stripes produce rather isotropic low
energy spin wave cones for a large range of parameters, despite local
microscopic anisotropy. We find that extra scattering intensity due to the
crossing of spin wave modes (which may be linked to the "resonance peak" in the
cuprates) is more likely for diagonal stripes, whether site- or bond-centered,
whereas spin wave bands generically repel, rather than cross, when stripes are
vertical.Comment: 12 pages, 12 figures, for some high-res.pics, see
http://physics.bu.edu/~yaodx/spinwave/spinw.htm
Weak Lensing Detection of Cl 1604+4304 at z = 0.90
We present a weak lensing analysis of the high-redshift cluster Cl 1604+4304.
At z=0.90, this is the highest-redshift cluster yet detected with weak lensing.
It is also one of a sample of high-redshift, optically-selected clusters whose
X-ray temperatures are lower than expected based on their velocity dispersions.
Both the gas temperature and galaxy velocity dispersion are proxies for its
mass, which can be determined more directly by a lensing analysis. Modeling the
cluster as a singular isothermal sphere, we find that the mass contained within
projected radius R is 3.69+-1.47 * (R/500 kpc) 10^14 M_odot. This corresponds
to an inferred velocity dispersion of 1004+-199 km/s, which agrees well with
the measured velocity dispersion of 989+98-76 km/s (Gal & Lubin 2004). These
numbers are higher than the 575+110-85 km/s inferred from Cl 1604+4304 X-ray
temperature, however all three velocity dispersion estimates are consistent
within ~ 1.9 sigma.Comment: Revised version accepted for publication in AJ (January 2005). 2
added figures (6 figures total
Like-charge attraction through hydrodynamic interaction
We demonstrate that the attractive interaction measured between like-charged
colloidal spheres near a wall can be accounted for by a nonequilibrium
hydrodynamic effect. We present both analytical results and Brownian dynamics
simulations which quantitatively capture the one-wall experiments of Larsen and
Grier (Nature 385, p. 230, 1997).Comment: 10 pages, 4 figure
Screening by symmetry of long-range hydrodynamic interactions of polymers confined in sheets
Hydrodynamic forces may significantly affect the motion of polymers. In
sheet-like cavities, such as the cell's cytoplasm and microfluidic channels,
the hydrodynamic forces are long-range. It is therefore expected that that
hydrodynamic interactions will dominate the motion of polymers in sheets and
will be manifested by Zimm-like scaling. Quite the opposite, we note here that
although the hydrodynamic forces are long-range their overall effect on the
motion of polymers vanishes due to the symmetry of the two-dimensional flow. As
a result, the predicted scaling of experimental observables such as the
diffusion coefficient or the rotational diffusion time is Rouse-like, in accord
with recent experiments. The effective screening validates the use of the
non-interacting blobs picture for polymers confined in a sheet.Comment: http://www.weizmann.ac.il/complex/tlusty/papers/Macromolecules2006.pdf
http://pubs.acs.org/doi/abs/10.1021/ma060251
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