Covid 19: How Really is the Epidemiological Curve? Epidemiological Curve Growth Rate is Less than One

This paper shows some views on the mathematical structure of the diffusion of the Coronavirus (COVID-19), often claimed to have a positive exponential structure. However, we find that the exponential growth rate is past the inflection point and that growth is much slower than this implication. It presents conclusions on the future expected outcome of the current situation-not only in terms of diffusion of the disease but also for the hysteria that have been created around it

Recognizing the Design Patterns of Complex Vaults: Drawing, Survey and Modeling. Experiments on Palazzo Mazzonis’ Atrium in Turin

This paper shows the results of research advances on complex vaulted systems produced by the integration of laser scanner survey techniques and three-dimensional modeling for the geometric interpretation of built architecture to recognizing the geometric matrices of the design conception. The integration between TLS techniques and digital modeling methods led to the definition of new workflows, aimed at optimizing the use of data and at refining the quality of the geometrical interpretation. The process incorporates the traditional activities of freehand drawing of eydotipes, aimed at a deep understanding of the peculiar characteristics of the artifact. In particular, from these procedures new opportunities for the research arise to better understand the relationships between survey data, geometric matrices and compositional rules. The case study presented here, the atrium of Palazzo Mazzonis in Turin was chosen among a small number of atria that present characteristics of originality and uniqueness in a panorama of realizations strongly characterized by compliance with well-established compositional schemes

FROM SURVEY TO 3D MODELLING TO DIGITAL FABRICATION. A WORKFLOW AIMED AT DOCUMENTING AND TRANSMITTING BUILT HERITAGE

This contribution illustrates the results of research that aims to connect the workflow for knowledge - survey, interpretation, modeling - to the transmission of this knowledge and enhancement of Cultural Heritage by physical models, demonstrating its potential in a "Design for All" perspective. Palazzo Mazzonis, the current seat of the MAO (Museo d’Arte Orientale), is one of the many buildings in the historic city center of Turin characterized by a particular complex vaulted atrium: it has been investigated through TLS survey tools for the production of two-dimensional drawings (for the detailed representation of architectural features) and three-dimensional models (for the interpretation of the design idea through geometry). The last phase of work aims to translate the interpretative digital models into tactile models for Cultural Heritage transmission, through processes of digital fabrication, with obvious impacts on the visit path inside the museum, also with didactic purposes

Efalizumab

Introduction: Conventional systemic therapies for psoriasis are associated with serious toxicities that can limit long-term use. In recent years, biological therapies have offered the possibility of long-term therapy with improved safety and efficacy for the treatment of psoriasis. Biological therapies can be classified into three categories: the T-cell modulating agents (alefacept and efalizumab), the inhibitors of TNF-alpha (adalimumab, etanercept, infliximab) and the inhibitors of IL-12 and -23 (ustekinumab). Efalizumab is a humanized recombinant monoclonal IgG1 antibody. It targets multiple stages in the immunopathogenesis of psoriasis: initial T-cell activation, migration of T-cells into dermal and epidermal tissues, and T-cell reactivation. On 19 February 2009, the Committee for Medicinal Products for Human Use (CHMP) recommended the suspension of the marketing authorisation for efalizumab.Areas covered: Numerous clinical trials have demonstrated the efficacy, safety and health-related quality of life benefits of efalizumab in patients with moderate-to-severe chronic plaque psoriasis. Efalizumab was approved by the FDA in November 2003 and by the European Medicines Evaluation Agency in September 2004 for the treatment of adult patients with moderate-to-severe chronic plaque psoriasis. Recently, three cases of progressive multifocal leukoencephalopathy were described in patients on long-term (> 3 years) efalizumab therapy, leading to its withdrawal from the market.Expert opinion: Although initially favorable, the safety profile of efalizumab revealed the appearance of severe adverse events in long-term treated patients. Therefore, post-marketing surveillance is essential for correct evaluation of drug potential

Does autonomic neuropathy play a role in erythropoietin regulation in non-proteinuric Type 2 diabetic patients?

Aims Erythropoietin (EPO)-deficient anaemia has been described in Type 1 diabetic patients with both severe autonomic neuropathy (AN) and proteinuria. This study was aimed at distinguishing between the effects of AN and nephropathy on haemoglobin and EPO levels in Type 2 diabetic patients at an early stage of diabetic nephropathy. Methods In 64 Type 2 diabetic patients (age 52 +/- 10 years, duration 10 +/- 9 years) without overt nephropathy and other causes of anaemia or EPO deficit, we assessed cardiovascular tests of AN, 24-h blood pressure (BP) monitoring, urinary albumin excretion rate (UAE), a full blood count, and serum EPO. Results Although the Type 2 diabetic patients with AN did not show differences in haemoglobin and EPO when compared with patients without AN, the presence of haemoglobin < 13 g/dl was associated with the presence of AN (chi(2)= 3.9, P < 0.05) and of postural hypotension (chi(2)= 7.8, P < 0.05). In a multiple regression analysis including as independent variables gender, body mass index, duration of diabetes, smoking, creatinine, 24-h UAE, 24-h diastolic BP, ferritin, erythrocyte sedimentation rate, and autonomic score, we found that the only variables independently related to haematocrit were autonomic score, ferritin and erythrocyte sedimentation rate. Finally, the physiological inverse relationship between EPO and haemoglobin present in a control group of 42 non-diabetic non-anaemic subjects was completely lost in Type 2 diabetic patients. The slopes of the regression lines between EPO and haemoglobin of the control subjects and the Type 2 diabetic patients were significantly different (t = 14.4, P < 0.0001). Conclusion This study documents an early abnormality of EPO regulation in Type 2 diabetes before clinical nephropathy and points to a contributory role of AN in EPO dysregulation