2,859 research outputs found
Naturalness bounds in extensions of the MSSM without a light Higgs boson
Adopting a bottom-up point of view, we make a comparative study of the
simplest extensions of the MSSM with extra tree level contributions to the
lightest Higgs boson mass. We show to what extent a relatively heavy Higgs
boson, up to 200-350 GeV, can be compatible with data and naturalness. The
price to pay is that the theory undergoes some change of regime at a relatively
low scale. Bounds on these models come from electroweak precision tests and
naturalness, which often requires the scale at which the soft terms are
generated to be relatively low.Comment: 18 pages, 5 figures. v2: minor revision, added references. v3,v4:
some numerical correction
Quantum Measurement Theory in Gravitational-Wave Detectors
The fast progress in improving the sensitivity of the gravitational-wave (GW)
detectors, we all have witnessed in the recent years, has propelled the
scientific community to the point, when quantum behaviour of such immense
measurement devices as kilometer-long interferometers starts to matter. The
time, when their sensitivity will be mainly limited by the quantum noise of
light is round the corner, and finding the ways to reduce it will become a
necessity. Therefore, the primary goal we pursued in this review was to
familiarize a broad spectrum of readers with the theory of quantum measurements
in the very form it finds application in the area of gravitational-wave
detection. We focus on how quantum noise arises in gravitational-wave
interferometers and what limitations it imposes on the achievable sensitivity.
We start from the very basic concepts and gradually advance to the general
linear quantum measurement theory and its application to the calculation of
quantum noise in the contemporary and planned interferometric detectors of
gravitational radiation of the first and second generation. Special attention
is paid to the concept of Standard Quantum Limit and the methods of its
surmounting.Comment: 147 pages, 46 figures, 1 table. Published in Living Reviews in
Relativit
A human MAP kinase interactome.
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using small interfering RNA knockdowns, we observed that approximately one-third of MAPK-interacting proteins modulated MAPK-mediated signaling. We uncovered the Na-H exchanger NHE1 as a potential MAPK scaffold, found links between HSP90 chaperones and MAPK pathways and identified MUC12 as the human analog to the yeast signaling mucin Msb2. This study makes available a large resource of MAPK interactions and clone libraries, and it illustrates a methodology for probing signaling networks based on functional refinement of experimentally derived protein-interaction maps
Testing Yukawa-unified SUSY during year 1 of LHC: the role of multiple b-jets, dileptons and missing E_T
We examine the prospects for testing SO(10) Yukawa-unified supersymmetric
models during the first year of LHC running at \sqrt{s}= 7 TeV, assuming
integrated luminosity values of 0.1 to 1 fb^-1. We consider two cases: the
Higgs splitting (HS) and the D-term splitting (DR3) models. Each generically
predicts light gluinos and heavy squarks, with an inverted scalar mass
hierarchy. We hence expect large rates for gluino pair production followed by
decays to final states with large b-jet multiplicity. For 0.2 fb^-1 of
integrated luminosity, we find a 5 sigma discovery reach of m(gluino) ~ 400 GeV
even if missing transverse energy, E_T^miss, is not a viable cut variable, by
examining the multi-b-jet final state. A corroborating signal should stand out
in the opposite-sign (OS) dimuon channel in the case of the HS model; the DR3
model will require higher integrated luminosity to yield a signal in the OS
dimuon channel. This region may also be probed by the Tevatron with 5-10 fb^-1
of data, if a corresponding search in the multi-b+ E_T^miss channel is
performed. With higher integrated luminosities of ~1 fb^-1, using E_T^miss plus
a large multiplicity of b-jets, LHC should be able to discover Yukawa-unified
SUSY with m(gluino) up to about 630 GeV. Thus, the year 1 LHC reach for
Yukawa-unified SUSY should be enough to either claim a discovery of the gluino,
or to very nearly rule out this class of models, since higher values of
m(gluino) lead to rather poor Yukawa unification.Comment: 32 pages including 31 EPS figure
Recommended from our members
NMR-based metabolic characterization of chicken tissues and biofluids: a model for avian research
Introduction
Poultry is one of the most consumed meat in the world and its related industry is always looking for ways to improve animal welfare and productivity. It is therefore essential to understand the metabolic response of the chicken to new feed formulas, various supplements, infections and treatments.
Objectives
As a basis for future research investigating the impact of diet and infections on chicken’s metabolism, we established a high-resolution proton nuclear magnetic resonance (NMR)-based metabolic atlas of the healthy chicken (Gallus gallus).
Methods
Metabolic extractions were performed prior to 1H-NMR and 2D NMR spectra acquisition on twelve biological matrices: liver, kidney, spleen, plasma, egg yolk and white, colon, caecum, faecal water, ileum, pectoral muscle and brain of 6 chickens. Metabolic profiles were then exhaustively characterized.
Results
Nearly 80 metabolites were identified. A cross-comparison of these matrices was performed to determine metabolic variations between and within each section and highlighted that only eight core metabolites were systematically found in every matrice.
Conclusion
This work constitutes a database for future NMR-based metabolomic investigations in relation to avian production and health
Management of venous thrombosis in fibular free osseomusculocutaneous flaps used for mandibular reconstruction: clinical techniques and treatment considerations
<p>Abstract</p> <p>Background</p> <p>Mandibular reconstruction by means of fibula transplants is the standard therapy for severe bone loss after subtotal mandibulectomy. Venous failure still represents the most common complication in free flap surgery. We present the injection of heparine into the arterial pedicle as modification of the revising both anastomoses in these cases and illustrate the application with a clinical case example.</p> <p>Methods</p> <p>Methods consist of immediate revision surgery with clot removal, heparin perfusion by direct injection in the arterial vessel of the pedicle, subsequent high dose low-molecular weight heparin therapy, and leeches. After 6 hours postoperatively, images of early flap recovery show first sings of recovery by fading livid skin color.</p> <p>Results</p> <p>The application of this technique in a patient with venous thrombosis resulted in the complete recovery of the flap 60 hours postoperatively. Other cases achieved similar success without additional lysis Therapy or revision of the arterial anastomosis.</p> <p>Conclusion</p> <p>Rescue of fibular flaps is possible even in patients with massive thrombosis if surgical revision is done quickly.</p
Biodiversity conservation: history, protected areas and hotspots
Angola is a large country of great physiographic, climatic and habitat
diversity, with a corresponding richness in animal and plant species. Legally protected
areas (National Parks and Game Reserves) were established from the 1930s
and occupied 6% of the country’s terrestrial area at the time of independence in
1975. As a consequence of an extended war, the Protected Areas were exposed to
serious neglect, poaching and land invasions. Many habitats of biogeographic
importance, and many rare and endemic species came under threat. The recently
strengthened administration gives cause for optimism that a new era for biodiversity
conservation is at hand. The Protected Areas system was greatly expanded in 2011,
and increasing resources are being made available towards achieving management
effectivenessinfo:eu-repo/semantics/publishedVersio
Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline
Cellular Radiosensitivity: How much better do we understand it?
Purpose: Ionizing radiation exposure gives rise to a variety of lesions in DNA that result in genetic instability and potentially tumorigenesis or cell death. Radiation extends its effects on DNA by direct interaction or by radiolysis of H2O that generates free radicals or aqueous electrons capable of interacting with and causing indirect damage to DNA. While the various lesions arising in DNA after radiation exposure can contribute to the mutagenising effects of this agent, the potentially most damaging lesion is the DNA double strand break (DSB) that contributes to genome instability and/or cell death. Thus in many cases failure to recognise and/or repair this lesion determines the radiosensitivity status of the cell. DNA repair mechanisms including homologous recombination (HR) and non-homologous end-joining (NHEJ) have evolved to protect cells against DNA DSB. Mutations in proteins that constitute these repair pathways are characterised by radiosensitivity and genome instability. Defects in a number of these proteins also give rise to genetic disorders that feature not only genetic instability but also immunodeficiency, cancer predisposition, neurodegeneration and other pathologies.
Conclusions: In the past fifty years our understanding of the cellular response to radiation damage has advanced enormously with insight being gained from a wide range of approaches extending from more basic early studies to the sophisticated approaches used today. In this review we discuss our current understanding of the impact of radiation on the cell and the organism gained from the array of past and present studies and attempt to provide an explanation for what it is that determines the response to radiation
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