Patellar luxation in dogs: a retrospective study

Submitted by Guilherme Lemeszenski ([email protected]) on 2013-08-22T18:56:14Z No. of bitstreams: 1 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5)Made available in DSpace on 2013-08-22T18:56:14Z (GMT). No. of bitstreams: 1 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) Previous issue date: 2009-04-01Made available in DSpace on 2013-09-30T19:49:57Z (GMT). No. of bitstreams: 2 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) S0102-09352009000200035.pdf.txt: 17158 bytes, checksum: 600eaaa16aa49e42de9ebec8926c8217 (MD5) Previous issue date: 2009-04-01Submitted by Vitor Silverio Rodrigues ([email protected]) on 2014-05-20T15:13:07Z No. of bitstreams: 2 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) S0102-09352009000200035.pdf.txt: 17158 bytes, checksum: 600eaaa16aa49e42de9ebec8926c8217 (MD5)Made available in DSpace on 2014-05-20T15:13:07Z (GMT). No. of bitstreams: 2 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) S0102-09352009000200035.pdf.txt: 17158 bytes, checksum: 600eaaa16aa49e42de9ebec8926c8217 (MD5) Previous issue date: 2009-04-01Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP Faculdade de Medicina Veterinária e ZootecniaUNESP Faculdade de Medicina Veterinária e Zootecni

Effect of different anesthetic agents on left ventricular systolic function assessed by echocardiography in hamsters

Determination of left ventricular ejection fraction (LVEF) using in vivo imaging is the cardiac functional parameter most frequently employed in preclinical research. However, there is considerable conflict regarding the effects of anesthetic agents on LVEF. This study aimed at assessing the effects of various anesthetic agents on LVEF in hamsters using transthoracic echocardiography. Twelve female hamsters were submitted to echocardiography imaging separated by 1-week intervals under the following conditions: 1) conscious animals, 2) animals anesthetized with isoflurane (inhaled ISO, 3 L/min), 3) animals anesthetized with thiopental (TP, 50 mg/kg, intraperitoneal), and 4) animals anesthetized with 100 mg/kg ketamine plus 10 mg/kg xylazine injected intramuscularly (K/X). LVEF obtained under the effect of anesthetics (ISO=62.2±3.1%, TP=66.2±2.7% and K/X=75.8±1.6%) was significantly lower than that obtained in conscious animals (87.5±1.7%, P<0.0001). The K/X combination elicited significantly higher LVEF values compared to ISO (P<0.001) and TP (P<0.05). K/X was associated with a lower dispersion of individual LVEF values compared to the other anesthetics. Under K/X, the left ventricular end diastolic diameter (LVdD) was increased (0.60±0.01 cm) compared to conscious animals (0.41±0.02 cm), ISO (0.51±0.02 cm), and TP (0.55±0.01 cm), P<0.0001. The heart rate observed with K/X was significantly lower than in the remaining conditions. These results indicate that the K/X combination may be the best anesthetic option for the in vivo assessment of cardiac systolic function in hamsters, being associated with a lower LVEF reduction compared to the other agents and showing values closer to those of conscious animals with a lower dispersion of results

Interleukin-18, interleukin-12B and interferon-\u3b3 gene polymorphisms in Brazilian patients with rheumatoid arthritis: A pilot study

Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-\u3b3 genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-\u3b3 +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio\u2009=\u20093.77; P\u2009<\u20090.0001). Individual carriers of the variant allele C had a 3.77-fold increased risk of for RA (P\u2009=\u20090.0032). No association was observed for IL-12B and IFN-\u3b3 polymorphisms. Our finds suggest a possible role for IL-18 polymorphism in the RA susceptibility in studied population

Securitização da dívida rural brasileira: o caso do Banco do Brasil de 1995 a 2008

No começo da década de 90, produtores rurais estavam endividados e não conseguiriam pagar seus financiamentos se não tivesse havido a renegociação desses débitos, a denominada securitização de dívidas rurais. O Banco do Brasil tinha impactos negativos nos seus resultados ocasionados pela inadimplência dos produtores, principalmente por ser a instituição mais importante em termos de crédito rural. Após um longo processo de negociações, foi aprovada a Lei n. 9.138, de 1995, que deu início à denominada securitização das dívidas. A partir da interpretação das leis sobre a securitização e da análise dos dados contidos nos relatórios contábeis-financeiros do Banco do Brasil, fez-se uma análise detalhada sobre o comportamento econômico-financeiro dessa instituição e constatou-se que a securitização foi essencial para o banco reverter seus prejuízos em lucros

Measurements with silicon photomultipliers of dose-rate effects in the radiation damage of plastic scintillator tiles in the CMS hadron endcap calorimeter

Measurements are presented of the reduction of signal output due to radiation damage for two types of plastic scintillator tiles used in the hadron endcap (HE) calorimeter of the CMS detector. The tiles were exposed to particles produced in proton-proton (pp) collisions at the CERN LHC with a center-of-mass energy of 13 TeV, corresponding to a delivered luminosity of 50 fb-1. The measurements are based on readout channels of the HE that were instrumented with silicon photomultipliers, and are derived using data from several sources: A laser calibration system, a movable radioactive source, as well as hadrons and muons produced in pp collisions. Results from several irradiation campaigns using 60Co sources are also discussed. The damage is presented as a function of dose rate. Within the range of these measurements, for a fixed dose the damage increases with decreasing dose rate