1,127 research outputs found
ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons
BACKGROUND: ASIC3, the most sensitive of the acid-sensing ion channels, depolarizes certain rat sensory neurons when lactic acid appears in the extracellular medium. Two functions have been proposed for it: 1) ASIC3 might trigger ischemic pain in heart and muscle; 2) it might contribute to some forms of touch mechanosensation. Here, we used immunocytochemistry, retrograde labelling, and electrophysiology to ask whether the distribution of ASIC3 in rat sensory neurons is consistent with either of these hypotheses. RESULTS: Less than half (40%) of dorsal root ganglion sensory neurons react with anti-ASIC3, and the population is heterogeneous. They vary widely in cell diameter and express different growth factor receptors: 68% express TrkA, the receptor for nerve growth factor, and 25% express TrkC, the NT3 growth factor receptor. Consistent with a role in muscle nociception, small (<25 μm) sensory neurons that innervate muscle are more likely to express ASIC3 than those that innervate skin (51% of small muscle afferents vs. 28% of small skin afferents). Over 80% of ASIC3+ muscle afferents co-express CGRP (a vasodilatory peptide). Remarkably few (9%) ASIC3+ cells express P2X3 receptors (an ATP-gated ion channel), whereas 31% express TRPV1 (the noxious heat and capsaicin-activated ion channel also known as VR1). ASIC3+/CGRP+ sensory nerve endings were observed on muscle arterioles, the blood vessels that control vascular resistance; like the cell bodies, the endings are P2X3- and can be TRPV1+. The TrkC+/ASIC3+ cell bodies are uniformly large, possibly consistent with non-nociceptive mechanosensation. They are not proprioceptors because they fail two other tests: ASIC3+ cells do not express parvalbumin and they are absent from the mesencephalic trigeminal nucleus. CONCLUSION: Our data indicates that: 1) ASIC3 is expressed in a restricted population of nociceptors and probably in some non-nociceptors; 2) co-expression of ASIC3 and CGRP, and the absence of P2X3, are distinguishing properties of a class of sensory neurons, some of which innervate blood vessels. We suggest that these latter afferents may be muscle metaboreceptors, neurons that sense the metabolic state of muscle and can trigger pain when there is insufficient oxygen
Gender specific quality of life in patients with oral squamous cell carcinomas
<p>Abstract</p> <p>Background</p> <p>The goal of this study was to evaluate the somatic and psychological effects by means of QUALITY OF LIFE (QOL) of surgical treatment of patients with oral squamous cell carcinoma. The factors gender, age, nicotine consumption, and tumour stage were taken into consideration.</p> <p>Methods</p> <p>54 patients after surgical resection of oral squamous cell carcinomas (OSCC) were analysed from 01.09.2005 to 31.05.2008. Inclusion criteria for the study were: age at least 18 years, no indication or treatment of synchronous and metachronous tumours.</p> <p>German translations of the EORTC H&N-35 and EORTC QLQ-C-30 questionnaires, as well as a general socioeconomic patient history were used as measuring instruments. The questionnaires were completed independently by the patients. The answers were translated into scale values for statistical evaluation using appropriate algorithms.</p> <p>Results</p> <p>Analysis of the EORTC-QLQ-C-30 questionnaires demonstrated a tendency of more negative assessment of emotional function among the female participants, and a more negative evaluation of social function among the male participants. Greater tumour sizes showed significantly lower bodily function (p = 0.018). While a smaller tumour size was significantly associated with lower cognitive functioning (p = 0.031). Other cofactors such as age, nicotine consumption, and tumour stage only showed a tendency to influence the quality of sleep and daily life.</p> <p>Conclusions</p> <p>The data obtained within this investigation demonstrated that gender had the most significant power on the subjectively perceived postoperative quality of life. This factor is important e.g. in preoperative decision making regarding immediate microvascular reconstruction after e.g. mandibular resection and therefore QOL assessment should become integral component of the care of patients with OSCC.</p
Activity driven modeling of time varying networks
Network modeling plays a critical role in identifying statistical
regularities and structural principles common to many systems. The large
majority of recent modeling approaches are connectivity driven. The structural
patterns of the network are at the basis of the mechanisms ruling the network
formation. Connectivity driven models necessarily provide a time-aggregated
representation that may fail to describe the instantaneous and fluctuating
dynamics of many networks. We address this challenge by defining the activity
potential, a time invariant function characterizing the agents' interactions
and constructing an activity driven model capable of encoding the instantaneous
time description of the network dynamics. The model provides an explanation of
structural features such as the presence of hubs, which simply originate from
the heterogeneous activity of agents. Within this framework, highly dynamical
networks can be described analytically, allowing a quantitative discussion of
the biases induced by the time-aggregated representations in the analysis of
dynamical processes.Comment: 10 pages, 4 figure
Contribution of Direct Heating, Thermal Conduction and Perfusion During Radiofrequency and Microwave Ablation
Both radiofrequency (RF) and microwave (MW) ablation devices are clinically used for tumor ablation. Several studies report less dependence on vascular mediated cooling of MW compared to RF ablation. We created computer models of a cooled RF needle electrode, and a dipole MW antenna to determine differences in tissue heat transfer
Whole animal experiments should be more like human randomized controlled trials
Beverly S. Muhlhausler, Frank H. Bloomfield, Matthew W. Gillma
Two Simple W' Models for the Early LHC
W' gauge bosons are good candidates for early LHC discovery. We define two
reference models, one containing a W'_R and one containing a W'_L, which may
serve as ``simplified models'' for presenting experimental results of W'
searches at the LHC. We present the Tevatron bounds on each model and compute
the constraints from precision electroweak observables. We find that indirect
low-energy constraints on the W'_L are quite strong. However, for a W'_R
coupling to right-handed fermions there exists a sizeable region in parameter
space beyond the bounds from the Tevatron and low-energy precision measurements
where even 50 inverse picobarns of integrated LHC luminosity are sufficient to
discover the W'_R. The most promising final states are two leptons and two
jets, or one lepton recoiling against a ``neutrino jet''. A neutrino jet is a
collimated object consisting of a hard lepton and two jets arising from the
decay of a highly boosted massive neutrino.Comment: 20 pages, 8 figures. v2: references adde
BOW SHOCK FRAGMENTATION DRIVEN BY A THERMAL INSTABILITY IN LABORATORY ASTROPHYSICS EXPERIMENTS
The role of radiative cooling during the evolution of a bow shock was studied
in laboratory-astrophysics experiments that are scalable to bow shocks present
in jets from young stellar objects. The laboratory bow shock is formed during
the collision of two counter-streaming, supersonic plasma jets produced by an
opposing pair of radial foil Z-pinches driven by the current pulse from the
MAGPIE pulsed-power generator. The jets have different flow velocities in the
laboratory frame and the experiments are driven over many times the
characteristic cooling time-scale. The initially smooth bow shock rapidly
develops small-scale non-uniformities over temporal and spatial scales that are
consistent with a thermal instability triggered by strong radiative cooling in
the shock. The growth of these perturbations eventually results in a global
fragmentation of the bow shock front. The formation of a thermal instability is
supported by analysis of the plasma cooling function calculated for the
experimental conditions with the radiative packages ABAKO/RAPCAL.Comment: 9 pages, 5 figures, Accepted for publication in The Astrophysical
Journal on 5th November 201
Approaching criticality via the zero dissipation limit in the abelian avalanche model
The discrete height abelian sandpile model was introduced by Bak, Tang &
Wiesenfeld and Dhar as an example for the concept of self-organized
criticality. When the model is modified to allow grains to disappear on each
toppling, it is called bulk-dissipative. We provide a detailed study of a
continuous height version of the abelian sandpile model, called the abelian
avalanche model, which allows an arbitrarily small amount of dissipation to
take place on every toppling. We prove that for non-zero dissipation, the
infinite volume limit of the stationary measure of the abelian avalanche model
exists and can be obtained via a weighted spanning tree measure. We show that
in the whole non-zero dissipation regime, the model is not critical, i.e.,
spatial covariances of local observables decay exponentially. We then study the
zero dissipation limit and prove that the self-organized critical model is
recovered, both for the stationary measure and for the dynamics. We obtain
rigorous bounds on toppling probabilities and introduce an exponent describing
their scaling at criticality. We rigorously establish the mean-field value of
this exponent for .Comment: 46 pages, substantially revised 4th version, title has been changed.
The main new material is Section 6 on toppling probabilities and the toppling
probability exponen
Interaction of a supersonic, radiatively cooled plasma jet with an ambient medium
International audienc
- …