22 research outputs found
Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment
Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This âgold standardâ has low sensitivity at low infection intensities. The urine point-of-care circulating cathodic antigen test (POC-CCA) is potentially more sensitive but how accurately they detect S. mansoni after repeated praziquantel treatments, their suitability for measuring drug efficacy and their correlation with egg counts remain to be fully understood. We compared the accuracies of one to six Kato-Katzs and one POC-CCA for the diagnosis of S. mansoni in primary-school children who have received zero to ten praziquantel treatments. We determined the impact each diagnostic approach may have on monitoring and evaluation (M&E) and drug-efficacy findings
The combination of three faecal parasitological methods to improve the diagnosis of schistosomiasis mansoni in a low endemic setting in the state of CearĂĄ, Brazil
Brand names of Portuguese medication: understanding the importance of their linguistic structure and regulatory issues
Understanding the relationship between egg- and antigen-based diagnostics of Schistosoma mansoni infection pre- and post-treatment in Uganda
Chromosomal inversion polymorphism in Drosophila mediopunctata: seasonal, altitudinal, and latitudinal variation
Cyanobacterial nitrogenases: phylogenetic diversity, regulation and functional predictions
Aspectos clĂnicos de pacientes com pitirĂase versicolor atendidos em um centro de referĂȘncia em dermatologia tropical na cidade de Manaus (AM), Brasil Clinical aspects of patients with pityriasis versicolor seen at a referral center for tropical dermatology in Manaus, Amazonas, Brazil
FUNDAMENTOS: A pitirĂase versicolor (tinha versicolor) Ă© uma micose superficial crĂŽnica, causada por leveduras do gĂȘnero Malassezia spp. comensais das camadas queratinizadas da pele e que, sob determinadas condiçÔes ainda nĂŁo esclarecidas, se torna patogĂȘnica, determinando as manifestaçÔes clĂnicas da doença. Ă uma dermatose recidivante e, mesmo apĂłs tratamento, pode deixar hipopigmentação persistente, causando problemas sociais aos indivĂduos acometidos. OBJETIVO: Descrever as caracterĂsticas clĂnicas e epidemiolĂłgicas de pacientes com diagnĂłstico de tinha versicolor atendidos em uma unidade de referĂȘncia em Dermatologia (Fundação Alfredo da Matta). MĂTODOS: Estudo de sĂ©rie de casos em que foram detalhadas as manifestaçÔes cutĂąneas e as caracterĂsticas epidemiolĂłgicas de pacientes atendidos na Fundação Alfredo da Matta com diagnĂłstico de tinha versicolor. RESULTADOS: Cento e dezesseis pacientes foram incluĂdos no estudo no perĂodo de janeiro a agosto de 2008. A maioria dos indivĂduos Ă© do sexo masculino, de cor parda, da faixa etĂĄria jovem e formada por estudantes, que apresentavam fatores predisponentes ao surgimento das manchas. TambĂ©m a maioria apresentava lesĂ”es extensas e histĂłria passada da doença. CONCLUSĂO: O estudo mostrou alta proporção de indivĂduos com quadros extensos e de longa duração da doença.<br>BACKGROUND: Pityriasis versicolor (tinea versicolor) is a chronic superficial mycosis caused by yeasts of the Malassezia spp. genus commensal of the keratinized layers of the skin. Under conditions not yet understood, it becomes pathogenic determining the clinical manifestations of the disease. It is a recurrent skin condition and persistent hypopigmentation may remain after treatment, causing social problems to those affected. OBJECTIVE: To describe the clinical and epidemiological features of patients diagnosed with tinea versicolor treated at a referral center for dermatology (Alfredo da Matta Foundation). METHODS: Case-studies in which cutaneous manifestations and epidemiological characteristics of patients diagnosed with tinea versicolor treated at Alfredo da Matta Foundation were detailed. RESULTS: One hundred and sixteen patients were included in the study from January to August 2008. Most subjects were male, of mixed ethnicity and young age. Most were students who were predisposed to the development of macules. The majority had extensive injuries and past history of the disease. CONCLUSION: The results revealed a high proportion of individuals with extensive clinical manifestations and duration of the disease