305 research outputs found
Thermally fluctuating superconductors in two dimensions
We describe the different regimes of finite temperature dynamics in the
vicinity of a zero temperature superconductor to insulator quantum phase
transition in two dimensions. New results are obtained for a low temperature
phase-only hydrodynamics, and for the intermediate temperature quantum-critical
region. In the latter case, we obtain a universal relationship between the
frequency-dependence of the conductivity and the value of the d.c. resistance.Comment: Presentation completely revised; 4 pages, 2 figure
Characterising Australian memory clinics: current practice and service needs informing national service guidelines
Background: Memory clinics (MCs) play a key role in accurate and timely diagnoses and treatment of dementia and mild cognitive impairment. However, within Australia, there are little data available on current practices in MCs, which hinder international comparisons for best practice, harmonisation efforts and national coordination. Here, we aimed to characterise current service profiles of Australian MCs. Methods: The ‘Australian Dementia Network Survey of Expert Opinion on Best Practice and the Current Clinical Landscape’ was conducted between August-September 2020 as part of a larger-scale Delphi process deployed to develop national MC guidelines. In this study, we report on the subset of questions pertaining to current practice including wait-times and post-diagnostic care. Results: Responses were received from 100 health professionals representing 60 separate clinics (45 public, 11 private, and 4 university/research clinics). The majority of participants were from clinics in metropolitan areas (79%) and in general were from high socioeconomic areas. While wait-times varied, only 28.3% of clinics were able to offer an appointment within 1-2 weeks for urgent referrals, with significantly more private clinics (58.3%) compared to public clinics (19.5%) being able to do so. Wait-times were less than 8 weeks for 34.5% of non-urgent referrals. Only 20.0 and 30.9% of clinics provided cognitive interventions or post-diagnostic support respectively, with 7.3% offering home-based reablement programs, and only 12.7% offering access to group-based education. Metropolitan clinics utilised neuropsychological assessments for a broader range of cases and were more likely to offer clinical trials and access to research opportunities. Conclusions: In comparison to similar countries with comprehensive government-funded public healthcare systems (i.e., United Kingdom, Ireland and Canada), wait-times for Australian MCs are long, and post-diagnostic support or evidence-based strategies targeting cognition are not common practice. The timely and important results of this study highlight a need for Australian MCs to adopt a more holistic service of multidisciplinary assessment and post-diagnostic support, as well as the need for the number of Australian MCs to be increased to match the rising number of dementia cases
Monopoles and Holography
We present a holographic theory in AdS_4 whose zero temperature ground state
develops a crystal structure, spontaneously breaking translational symmetry.
The crystal is induced by a background magnetic field, but requires no chemical
potential. This lattice arises from the existence of 't Hooft-Polyakov monopole
solitons in the bulk which condense to form a classical object known as a
monopole wall. In the infra-red, the magnetic field is screened and there is an
emergent SU(2) global symmetry.Comment: 33 pages, 16 figures; v2: ref adde
Quantum critical states and phase transitions in the presence of non equilibrium noise
Quantum critical points are characterized by scale invariant correlations and
correspondingly long ranged entanglement. As such, they present fascinating
examples of quantum states of matter, the study of which has been an important
theme in modern physics. Nevertheless very little is known about the fate of
quantum criticality under non equilibrium conditions. In this paper we
investigate the effect of external noise sources on quantum critical points. It
is natural to expect that noise will have a similar effect to finite
temperature, destroying the subtle correlations underlying the quantum critical
behavior. Surprisingly we find that in many interesting situations the
ubiquitous 1/f noise preserves the critical correlations. The emergent states
show intriguing interplay of intrinsic quantum critical and external noise
driven fluctuations. We demonstrate this general phenomenon with specific
examples in solid state and ultracold atomic systems. Moreover our approach
shows that genuine quantum phase transitions can exist even under non
equilibrium conditions.Comment: 9 pages, 2 figure
Quantum Criticality in Heavy Fermion Metals
Quantum criticality describes the collective fluctuations of matter
undergoing a second-order phase transition at zero temperature. Heavy fermion
metals have in recent years emerged as prototypical systems to study quantum
critical points. There have been considerable efforts, both experimental and
theoretical, which use these magnetic systems to address problems that are
central to the broad understanding of strongly correlated quantum matter. Here,
we summarize some of the basic issues, including i) the extent to which the
quantum criticality in heavy fermion metals goes beyond the standard theory of
order-parameter fluctuations, ii) the nature of the Kondo effect in the quantum
critical regime, iii) the non-Fermi liquid phenomena that accompany quantum
criticality, and iv) the interplay between quantum criticality and
unconventional superconductivity.Comment: (v2) 39 pages, 8 figures; shortened per the editorial mandate; to
appear in Nature Physics. (v1) 43 pages, 8 figures; Non-technical review
article, intended for general readers; the discussion part contains more
specialized topic
ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups
Clinical manifestations and endoscopic findings of amebic colitis in a United States-Mexico border city: a case series
A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk.
The associations between serum concentrations of insulin-like growth factor-I (IGF-I), IGF-II and IGF-binding proteins (IGFBP)-3 and risk of breast cancer were investigated in a nested case-control study involving 117 cases (70 premenopausal and 47 postmenopausal at blood collection) and 350 matched controls within a cohort of women from the island of Guernsey, UK. Women using exogenous hormones at the time of blood collection were excluded. Premenopausal women in the top vs bottom third of serum IGF-I concentration had a nonsignificantly increased risk for breast cancer after adjustment for IGFBP-3 (odds ratio (OR) 1.71; 95% confidence interval (CI): 0.74-3.95; test for linear trend, P=0.21). Serum IGFBP-3 was associated with a reduction in risk in premenopausal women after adjustment for IGF-I (top third vs the bottom third: OR 0.49; 95% CI: 0.21-1.12, P for trend=0.07). Neither IGF-I nor IGFBP-3 was associated with risk in postmenopausal women and serum IGF-II concentration was not associated with risk in pre- or postmenopausal women. These data are compatible with the hypothesis that premenopausal women with a relatively high circulating concentration of IGF-I and low IGFBP-3 are at an increased risk of developing breast cancer
SUMOylation of DRIL1 Directs Its Transcriptional Activity Towards Leukocyte Lineage-Specific Genes
DRIL1 is an ARID family transcription factor that can immortalize primary mouse fibroblasts, bypass RASV12-induced cellular senescence and collaborate with RASV12 or MYC in mediating oncogenic transformation. It also activates immunoglobulin heavy chain transcription and engages in heterodimer formation with E2F to stimulate E2F-dependent transcription. Little, however, is known about the regulation of DRIL1 activity. Recently, DRIL1 was found to interact with the SUMO-conjugating enzyme Ubc9, but the functional relevance of this association has not been assessed. Here, we show that DRIL1 is sumoylated both in vitro and in vivo at lysine 398. Moreover, we provide evidence that PIASy functions as a specific SUMO E3-ligase for DRIL1 and promotes its sumoylation both in vitro and in vivo. Furthermore, consistent with the subnuclear localization of PIASy in the Matrix-Associated Region (MAR), SUMO-modified DRIL1 species are found exclusively in the MAR fraction. This post-translational modification interferes neither with the subcellular localization nor the DNA-binding activity of the protein. In contrast, DRIL1 sumoylation impairs its interaction with E2F1 in vitro and modifies its transcriptional activity in vivo, driving transcription of subset of genes regulating leukocyte fate. Taken together, these results identify sumoylation as a novel post-translational modification of DRIL1 that represents an important mechanism for targeting and modulating DRIL1 transcriptional activity
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