Robust control of robot manipulators using hybrid H∞/adaptive controller

A robust hybrid control method for robot manipulators is proposed which integrates an H∞ controller and an adaptive controller. The H∞ controller is used to minimize the effect of parameter uncertainties of the robot model on the tracking performance, while the adaptive controller continuously adjusts the model parameters to reduce the model error. Simulations show that disturbances generated from the model error will be quickly compensated and so small tracking errors can be achieved.published_or_final_versio

Reliability and validity of the overactive bladder symptom score in Hong Kong Chinese

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Roles of endothelin-1 in beta-amyloid-induced neurotoxicity in hippocampus: an implication for Alzheimer’s pathology

Poster F - Nervous System Disorders: abstract no. P3-F-012The British Neuroscience Association’s Festival of NeuroscienceAlzheimer’s disease (AD) is an incurable neurodegenerative disorder. Abnormal levels of endothelin-1 (ET-1) have been demonstrated in parietal white matter(1), cerebral cortex and vessels of the AD brain(2). Neuronal death and accumulation of beta-amyloid (Aβ) are prominent pathological features of AD. Significant neuronal death is found in Aβ-treated primary neurons and Aβ-overexpressing mouse models(3,4). ET-1 is a known vasoconstrictor and neuro-active peptide. ET-1 induces apoptosis in primary retinal neurons(5). In contrary, ET-receptor (ETR) type B agonist can rescue neurons from Aβ-induced apoptosis(6). These findings suggest ET-1 plays dual roles in neurodegeneration and neuroprotection, respectively. This study aims to investigate the effect of ET-1 on Aβ-induced cell death in hippocampal neurons. Primary hippocampal neurons were pretreated with or without ETR antagonists prior to the treatment of oligomeric form of Aβ1-42, ET-1 or both on 14 DIV. Cell viability was measured by MTT assay. Changes in protein expression in apoptotic and ET-1 signaling pathways were assessed by western-blot analysis. This study shed light on the roles of ET-1 in Aβ1-42-neurotoxicity, building upon which the ET-1 signaling pathway as a potential therapeutic target for AD can be further investigated.published_or_final_versio

Fiber optics and photonics : emerging applications - introduction to the feature issue

Author name used in this publication: H. Y. TamVersion of RecordPublishe

Elucidating the aetiology of human Campylobacter coli infections

Peer reviewedPublisher PD

Chinese patients with sporadic Hirschsprung's disease are predominantly represented by a single RET haplotype.

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Polarization-maintaining photonic-crystal-fiber-based all-optical polarimetric torsion sensor

Author name used in this publication: P. K. A. WaiAuthor name used in this publication: H. Y. TamAuthor name used in this publication: C. Lu2010-2011 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Pressure sensor realized with polarization-maintaining photonic crystal fiber-based Sagnac interferometer

Author name used in this publication: H. Y. TamAuthor name used in this publication: Li-Yang ShaoAuthor name used in this publication: P. K. A. WaiAuthor name used in this publication: C. Lu2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe