An exploration of the determinants for decision to migrate existing resources to cloud computing using an integrated TOE-DOI model

Migrating existing resources to cloud computing is a strategic organisational decision that can be difficult. It requires the consideration and evaluation of a wide range of technical and organisational aspects. Although a significant amount of attention has been paid by many industrialists and academics to aid migration decisions, the procedure remains difficult. This is mainly due to underestimation of the range of factors and characteristics affecting the decision for cloud migration. Further research is needed to investigate the level of effect these factors have on migration decisions and the overall complexity. This paper aims to explore the level of complexity of the decision to migrate the cloud. A research model based on the diffusion of innovation (DOI) theory and the technology-organization-environment (TOE) framework was developed. The model was tested using exploratory and confirmatory factor analysis. The quantitative analysis shows the level of impact of the identified variables on the decision to migrate. Seven determinants that contribute to the complexity of the decisions are identified. They need to be taken into account to ensure successful migration. This result has expanded the collective knowledge about the complexity of the issues that have to be considered when making decisions to migrate to the cloud. It contributes to the literature that addresses the complex and multidimensional nature of migrating to the cloud

Cerium oxide nanoparticles promote neurogenesis and abrogate hypoxia-induced memory impairment through AMPK–PKC–CBP signaling cascade

Aditya Arya,1 Anamika Gangwar,1 Sushil Kumar Singh,2 Manas Roy,3,4 Mainak Das,3 Niroj Kumar Sethy,1 Kalpana Bhargava1 1Peptide and Proteomics Division, Defense Institute of Physiology and Allied Sciences, 2Functional Materials Division, Solid State Physics Laboratory, Defense Research and Development Organization, Timarpur, Delhi, 3Biological Science and Bioengineering, Indian Institute of Technology, Kanpur, 4Department of Chemistry, Indian Institute of Engineering Science and Technology, Howrah, India Abstract: Structural and functional integrity of the brain is adversely affected by reduced oxygen saturation, especially during chronic hypoxia exposure and often encountered by altitude travelers or dwellers. Hypoxia-induced generation of reactive nitrogen and oxygen species reportedly affects the cortex and hippocampus regions of the brain, promoting memory impairment and cognitive dysfunction. Cerium oxide nanoparticles (CNPs), also known as nanoceria, switch between +3 and +4 oxidation states and reportedly scavenge superoxide anions, hydrogen peroxide, and peroxynitrite in vivo. In the present study, we evaluated the neuroprotective as well as the cognition-enhancing activities of nanoceria during hypobaric hypoxia. Using polyethylene glycol-coated 3 nm nanoceria (PEG-CNPs), we have demonstrated efficient localization of PEG-CNPs in rodent brain. This resulted in significant reduction of oxidative stress and associated damage during hypoxia exposure. Morris water maze-based memory function tests revealed that PEG-CNPs ameliorated hypoxia-induced memory impairment. Using microscopic, flow cytometric, and histological studies, we also provide evidences that PEG-CNPs augmented hippocampus neuronal survival and promoted neurogenesis. Molecular studies revealed that PEG-CNPs promoted neurogenesis through the 5'-adenine monophosphate-activated protein kinase–protein kinase C–cyclic adenosine monophosphate response element-binding protein binding (AMPK-PKC-CBP) protein pathway. Our present study results suggest that nanoceria can be translated as promising therapeutic molecules for neurodegenerative diseases. Keywords: cerium oxide nanoparticles, oxidative stress, memory, hypoxia, neuroprotectio

Structural and magnetic characterization of Zr-substituted magnetite (ZrxFe3-xO4, 0 <= x <= 1)

We report the preparation of monophasic Zr-substituted magnetite (ZrxFe3-xO4; 0 0.4 respectively. The ferrofluids prepared from these magnetic nanoparticles possessed good heating ability and Specific Absorption Rate (SAR) values suitable for bioapplications. (C) 2015 Elsevier B.V. All rights reserved

Application of molecular markers to find out classificatory determinants of rice (Oryza sativa L.)

The present communication is aimed to find out determinants of molecular marker based classification of rice (Oryza sativa L) germplasm using the available data from an experiment conducted for development of molecular fingerprints of diverse varieties of Basmati and non Basmati rice adapted to irrigated and aerobic agro-eco systems. The distance-matrix based dendrogram was developed following UPGMA method that grouped all the 44 varieties agro-eco systems wise. We examined the clustering of Basmati and non- Basmati varieties in detail. The results suggest that the easily distinguishable simple characters viz. plant height, photosensitivity, leaf color, awn’s color, awns’ number etc., governed by major genes did not contribute significantly towards classification of rice genotypes used. The complex characters such as adaptation to agro-eco systems and rice quality may play vital role in determination of molecular marker based classification of rice genotypes. Key word: Basmati rice, molecular markers, genetic diversity, agro-eco systems, rice qualit

Optimization Control on Growth Morphology, Lattice Scale Features and Optical Response of Al-Incorporated ZnO Nano-Needles

A simple approach to synthesize zinc oxide nano-needles using aluminum incorporation at different concentrations (0, 0.5, 2, 5% Al) is reported and a detailed real and reciprocal space imaging is performed employing scanning as well as high resolution transmission electron microscopes which revealed the morphological alterations and provided a comprehensible representation of evolution of fascinating nanostructures, depending on Al-content in bare ZnO. Subsequently optical investigations were carried out by employing UV-Vis, PL and FT-IR spectroscopy inferred to a basis for significant structure-property correlation leading for 2% Al incorporation in ZnO matrix as the highest quality luminescent material.X1144sciescopu

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