The genetics of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems, defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation

'Surgical cure' for non-parathyroid hypercalcemia

Background: Sarcoidosis is a granulomatous disease of unknown aetiology. Over 90% patients of sarcoidosis present with pulmonary findings. Other organs such as lymph nodes, skin, and joints may be involved. Isolated granulomatous disease confined to the spleen is rare. Case presentation: This report documents a rare case of isolated granulomatous disease of spleen presenting as hypercalcemia. After all possible causes for hypercalcemia were ruled out, splenectomy was done which proved diagnostic and therapeutic, as calcium levels returned to normal. Conclusion: We propose that sarcoidosis should be kept in mind as a cause of unexplained hypercalcemia. Increased awareness of radiological features of splenic involvement in sarcoidosis, would help in diagnosis. We believe that we are reporting 9th case in the literature while writing this report

Municipal performance in waste recycling: an empirical analysis based on data from the Lombardy region (Italy)

By using a large cross-sectional dataset that observes municipalities from one of the most populated and wealthiest regions in Europe (Lombardy, Italy), this paper investigates how municipal waste re-cycling is correlated with a wide set of municipallevel variables. Results show that municipal waste recycling is linked to geographical, demographic, socio-economic and political variables. They also reveal that these tendencies vary according to municipalities’ population size. This empirical analysis helps in identifying those municipalities that have higher probability of being virtuous in terms of waste recycling