4,550 research outputs found
Investigating the effects of long-term dornase alfa use on lung function using registry data.
BACKGROUND: Dornase alfa (DNase) is one of the commonest cystic fibrosis (CF) treatments and is often used for many years. However, studies have not evaluated the effectiveness of its long-term use. We aimed to use UK CF Registry data to investigate the effects of one-, two-, three-, four- and five-years of DNase use on lung function to see if the benefits of short-term treatment use are sustained long term. METHODS: We analysed data from 4,198 people in the UK CF Registry from 2007 to 2015 using g-estimation. By controlling for time-dependent confounding we estimated the effects of long-term DNase use on percent predicted FEV1 (ppFEV1) and investigated whether the effect differed by ppFEV1 at treatment initiation or by age. RESULTS: Considering the population as a whole, there was no significant effect of one-year's use of DNase; change in ppFEV1 over one year was -0.1% in the treated compared to the untreated (p = 0.51) and this did not change with long-term use. However, treatment was estimated to be more beneficial in people with lower lung function (p 70%
N=2 Conformal Superspace in Four Dimensions
We develop the geometry of four dimensional N=2 superspace where the entire
conformal algebra of SU(2,2|2) is realized linearly in the structure group
rather than just the SL(2,C) x U(2)_R subgroup of Lorentz and R-symmetries,
extending to N=2 our prior result for N=1 superspace. This formulation
explicitly lifts to superspace the existing methods of the N=2 superconformal
tensor calculus; at the same time the geometry, when degauged to SL(2,C) x
U(2)_R, reproduces the existing formulation of N=2 conformal supergravity
constructed by Howe.Comment: 43 pages; v2 references added, acknowledgments update
Impact of Scottish smoke-free legislation on smoking quit attempts and prevalence
<p><b>Objectives:</b> In Scotland, legislation was implemented in March 2006 prohibiting smoking in all wholly or partially enclosed public spaces. We investigated the impact on attempts to quit smoking and smoking prevalence.</p>
<p><b>Methods:</b> We performed time series models using Box-Jenkins autoregressive integrated moving averages (ARIMA) on monthly data on the gross ingredient cost of all nicotine replacement therapy (NRT) prescribed in Scotland in 2003–2009, and quarterly data on self-reported smoking prevalence between January 1999 and September 2010 from the Scottish Household Survey.</p>
<p><b>Results:</b> NRT prescription costs were significantly higher than expected over the three months prior to implementation of the legislation. Prescription costs peaked at £1.3 million in March 2006; £292,005.9 (95% CI £260,402.3, £323,609, p<0.001) higher than the monthly norm. Following implementation of the legislation, costs fell exponentially by around 26% per month (95% CI 17%, 35%, p<0.001). Twelve months following implementation, the costs were not significantly different to monthly norms. Smoking prevalence fell by 8.0% overall, from 31.3% in January 1999 to 23.7% in July–September 2010. In the quarter prior to implementation of the legislation, smoking prevalence fell by 1.7% (95% CI 2.4%, 1.0%, p<0.001) more than expected from the underlying trend.</p>
<p><b>Conclusions:</b> Quit attempts increased in the three months leading up to Scotland's smoke-free legislation, resulting in a fall in smoking prevalence. However, neither has been sustained suggesting the need for additional tobacco control measures and ongoing support.</p>
Generalization Error in Deep Learning
Deep learning models have lately shown great performance in various fields
such as computer vision, speech recognition, speech translation, and natural
language processing. However, alongside their state-of-the-art performance, it
is still generally unclear what is the source of their generalization ability.
Thus, an important question is what makes deep neural networks able to
generalize well from the training set to new data. In this article, we provide
an overview of the existing theory and bounds for the characterization of the
generalization error of deep neural networks, combining both classical and more
recent theoretical and empirical results
Extended supersymmetric sigma models in AdS_4 from projective superspace
There exist two superspace approaches to describe N=2 supersymmetric
nonlinear sigma models in four-dimensional anti-de Sitter (AdS_4) space: (i) in
terms of N=1 AdS chiral superfields, as developed in arXiv:1105.3111 and
arXiv:1108.5290; and (ii) in terms of N=2 polar supermultiplets using the AdS
projective-superspace techniques developed in arXiv:0807.3368. The virtue of
the approach (i) is that it makes manifest the geometric properties of the N=2
supersymmetric sigma-models in AdS_4. The target space must be a non-compact
hyperkahler manifold endowed with a Killing vector field which generates an
SO(2) group of rotations on the two-sphere of complex structures. The power of
the approach (ii) is that it allows us, in principle, to generate hyperkahler
metrics as well as to address the problem of deformations of such metrics.
Here we show how to relate the formulation (ii) to (i) by integrating out an
infinite number of N=1 AdS auxiliary superfields and performing a superfield
duality transformation. We also develop a novel description of the most general
N=2 supersymmetric nonlinear sigma-model in AdS_4 in terms of chiral
superfields on three-dimensional N=2 flat superspace without central charge.
This superspace naturally originates from a conformally flat realization for
the four-dimensional N=2 AdS superspace that makes use of Poincare coordinates
for AdS_4. This novel formulation allows us to uncover several interesting
geometric results.Comment: 88 pages; v3: typos corrected, version published in JHE
The linear multiplet and ectoplasm
In the framework of the superconformal tensor calculus for 4D N=2
supergravity, locally supersymmetric actions are often constructed using the
linear multiplet. We provide a superform formulation for the linear multiplet
and derive the corresponding action functional using the ectoplasm method (also
known as the superform approach to the construction of supersymmetric
invariants). We propose a new locally supersymmetric action which makes use of
a deformed linear multiplet. The novel feature of this multiplet is that it
corresponds to the case of a gauged central charge using a one-form potential
not annihilated by the central charge (unlike the standard N=2 vector
multiplet). Such a gauge one-form can be chosen to describe a variant nonlinear
vector-tensor multiplet. As a byproduct of our construction, we also find a
variant realization of the tensor multiplet in supergravity where one of the
auxiliaries is replaced by the field strength of a gauge three-form.Comment: 31 pages; v3: minor corrections and typos fixed, version to appear in
JHE
Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia [version 2; peer review: 2 approved with reservations]
Background: The current study sought to develop a valid, reliable and
unobtrusive tablet computer-based observational measure to assess
engagement of people with advanced dementia. The Video Analysis
Scale of Engagement (VASE) was designed to enable the rating of
moment-by-moment changes in engagement during an activity, which
would be useful for both future research and current residential care.
Methods: An initial version of the VASE was tested. Face validity and
content validity were assessed to validate an operational definition of
engagement and develop an acceptable protocol for the scale. Thirtyseven
non-professional and professional volunteers were recruited to
view and rate level of engagement in music activities using the VASE.
Results: An inter-class coefficient (ICC) test gave a high level of rating
agreement across professionals and non-professionals. However, the
ICC results of within-professionals were mixed. Linear mixed
modelling suggested that the types of interventions (active or passive
music listening), the particular intervention session being rated, time
period of video and the age of raters could affect the ratings.
Conclusions: Results suggested that raters used the VASE in a
dynamic fashion and that the measure was able to distinguish
between interventions. Further investigation and adjustments are
warranted for this to be considered a valid and reliable scale in the
measurement of engagement of people with advanced dementia in a
residential care setting
Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia [version 3; peer review: 1 approved, 1 approved with reservations]
BACKGROUND:
The current study sought to develop a valid, reliable and unobtrusive tablet computer-based observational measure to assess engagement of people with advanced dementia. The Video Analysis Scale of Engagement (VASE) was designed to enable the rating of moment-by-moment changes in engagement during an activity, which would be useful for both future research and current residential care.
METHODS:
An initial version of the VASE was tested. Face validity and content validity were assessed to validate an operational definition of engagement and develop an acceptable protocol for the scale. Thirty-seven non-professional and professional volunteers were recruited to view and rate level of engagement in music activities using the VASE.
RESULTS:
An inter-class coefficient (ICC) test gave a high level of rating agreement across professionals and non-professionals. However, the ICC results of within-professionals were mixed. Linear mixed modelling suggested that the types of interventions (active or passive music listening), the particular intervention session being rated, time period of video and the age of raters could affect the ratings.
CONCLUSIONS:
Results suggested that raters used the VASE in a dynamic fashion and that the measure was able to distinguish between interventions. Further investigation and adjustments are warranted for this to be considered a valid and reliable scale in the measurement of engagement of people with advanced dementia in a residential care setting
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