Secukinumab shows high efficacy irrespective of HLA-Cw6 status in patients with moderate-to-severe plaque-type psoriasis: SUPREME study

Background: Understanding genetic variations is important in predicting treatment response and forms the basis for identifying new pharmacogenetic and pharmacogenomic targets for psoriasis treatment. There are limited data on the efficacy of secukinumab in relation to genetic markers. Objectives: To evaluate the efficacy and safety of secukinumab 300 mg in HLA-Cw6-positive (Cw6-POS) and HLA-Cw6-negative (Cw6-NEG) patients with moderate-to-severe chronic plaque-type psoriasis. Methods: SUPREME was a 24-week, phase IIIb study with an extension period up to 72 weeks. Primary end point was Psoriasis Area Severity Index (PASI) 90 response rate after 16 weeks. Results: In total, 434 patients were recruited: 185 (42\ub76%) were Cw6-POS and 246 (56\ub77%) were Cw6-NEG (three not assessed). Mean \ub1 SD age was 45\ub72 \ub1 13\ub72 years (Cw6-POS 42\ub77 \ub1 13\ub71; Cw6-NEG 47\ub72 \ub1 12\ub79). The baseline PASI score was comparable between the cohorts [Cw6-POS 20\ub77 \ub1 8\ub799; Cw6-NEG 21\ub75 \ub1 9\ub799 (P = 0\ub7777)]. At week 16, PASI 90 was achieved in 80\ub74% of Cw6-POS and 79\ub77% of Cw6-NEG patients (difference 0\ub776; 95% confidence interval 127\ub704 to 8\ub723). No differences in absolute PASI at week 16 (Cw6-POS 1\ub736 \ub1 3\ub758; Cw6-NEG 1\ub718 \ub1 2\ub729) were observed. The overall safety profile of secukinumab was consistent with that previously reported. No statistically significant difference was detected in the rate of treatment-emergent adverse events [Cw6-POS 42\ub77%; Cw6-NEG 49\ub76% (P = 0\ub7295)]. A high PASI 90 response was achieved with secukinumab with a fast reduction in absolute PASI. Conclusions: Determination of HLA-Cw6 status for secukinumab therapy is unnecessary, as it is highly effective regardless of HLA-Cw6 status

Geology and paleontology of the South-western carbonate edge of Fucino Plain (Abruzzi, central Apennines)

This paper describes the carbonate succession of Lower Cretaceous to Middle Miocene sediments cropping out along the south-western edge of Fucino Plain. Particular attention was given to the paleontological analysis of these limestones, aimed at defining the stratigraphy, paleoecological and paleoenvironmental conditions of the area under investigation. The mountain relief is divided into two sections by the confluence of the Vallelonga depression and Fucino Plain. The section to the E of the Vallelonga depression (Trasacco mountains) is limited along the valley by a normal fault with NW-SE strike and it consists of Hauterivian-Albian limestones overlaid by limited transgressive Middle Miocene limestones. These ones have never been reported before in the literature; they are the document of the extended stratigraphic gap which characterized this area in the Late Cretaceous and Paleogene times. The analysis of textural, sedimentological and paleontological data has led to the discovery of a stretch of the carbonate platform edge on the relief northern slope: on the contrary the remaining part of the mountain structure presents inner platform-lagoon environmental conditions. In the section to the W of the Vallelonga depression (Luco dei Marsi-Madonna Candelecchia area), Upper Aptian to Campanian limestones crop out; depositional environment changed from restricted conditions in the Aptian-Albian time to open platform environment in the Senonian one. This general outline allow us to conclude that, during the Cretaceous time, the Vallelonga fault has probably downthrown the western section of the area where the sedimentation continued until the Campanian time

Low energy vs. high energy depositional settings and related sedimentary bodies in early Senenian rudist bearing carbonate shelves (central-southern Italy)

Carannante Gabriele, Laviano A., Ruberti D., Simone Lucia, Sirna G., Sirna M., Tropeano M. Low energy vs. high energy depositional settings and related sedimentary bodies in early Senenian rudist bearing carbonate shelves (central-southern Italy). In: Géologie Méditerranéenne. Tome 28, numéro 1-2, 2001. Anatomy of Carbonate Bodies / Anatomie des corps carbonates. International Meeting / Colloque international. Marseille, 9-12 mai 2001, France, sous la direction de Marc Floquet, Jérôme Hennuy et Jean-Pierre Masse. pp. 37-40

Social processes of health and physical education teachers' identity formation: Reproducing and changing culture

This paper examines Initial Teacher Education students' experiences of participation in health and physical education (HPE) subject department offices and the impact on their understandings and identity formation. Pierre Bourdieu's concepts of habitus, field, and practice along with Wenger's communities of practice form the theoretical frame used in the paper. Data were collected using surveys and interviews with student-teachers following their teaching practicum and analysed using coding and constant comparison. Emergent themes revealed students' participation in masculine-dominated sports, gendered body constructions, and repertoires of masculine domination. Findings are discussed in relation to their impact on student-teachers' learning, identity formation, and marginalizing practices in the department offices. Implications for teacher education and HPE are explored.Peer reviewedFinal article publishedidentity constructionagencysocial reproductionsubject department officesstudent‐teacher