Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow

Aim: To investigate iron loading within the liver, pancreas, spleen, and bone marrow using magnetic resonance imaging (MRI) transverse relaxation rate (R2*), in patients with diffuse liver diseases; to evaluate the relationships between iron accumulation in these tissue compartments; and to assess the association between tissue iron overload and the pattern of hepatic cellular iron distribution (hepatocytes versus Kupffer cells). Material and methods: Fifty-six patients with diffuse liver diseases had MRI-derived R2* values, using a multi-echo chemical-shift encoded MRI sequence, of the liver, pancreas, spleen, and vertebral bone marrow. All patients had liver biopsy samples scored for hepatic iron grading (0–4) and iron cellular distribution (within hepatocytes only or within both hepatocytes and Kupffer cells). Results: Liver R2* increased with histological iron grade (RS=0.58, p<0.001) and correlated with spleen (RS=0.71, p<0.001) and bone marrow R2* (RS=0.66, p<0.001), but not with pancreatic R2* (RS=0.22, p=0.096). Splenic and bone marrow R2* values were also correlated (RS=0.72, p<0.001). Patients with iron inside Kupffer cells had the highest R2* in liver, spleen and bone marrow. Conclusions: Patients with chronic diffuse liver diseases have concomitant hepatic, splenic, and bone marrow iron loading. The highest hepatic iron scores and iron inside Kupffer cells were associated with the highest splenic and bone marrow deposits, suggesting systemic iron accumulation in the mononuclear phagocytic system.The present study was supported by the Teaching and Research Department of Centro Hospitalar do Porto with a research grant number DEFI:309/12(213-DEFI/251-CES). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. L.M.B. and A.A.B. are co-founders of QUIBIM SME

A pipeline to study structural interactions among Spodoptera frugiperda serine proteinases and plant proteinase inhibitors.

We propose here a computational biology pipeline to identify and analyze possible structural determinants that could explain some level of insensitivity by S. frugiperda serine proteinases (SPs) against plant PIs observed in a real time PCR experiment.GA 330

Biochars from animal wastes as alternative materials to treat colored effluents containing Basic Red 9

Bovine bones (BB) and fish scales (FS) were used as alternative precursors to produce biochars, which in turn, were applied for the removal of Basic Red 9 (BR9) from aqueous solutions. BB and FS were pyrolyzed generating a solid (biochars), a liquid (pyrolytic oils) and a gas fraction. All fractions were characterized to evaluate the pyrolysis process. The biochars presented different functional groups and a mesoporous structure with surface areas around 90 m2 g–1. Both biochars demonstrated potential to adsorb BR9, with maximum adsorption capacities of 49.5 (BB–biochar) and 52.3 mg g–1 (FS–biochar). Pyrolytic oils were composed mainly by palmitic acid (BB) and imidazolidinedione (FS), which are compounds with biological and antioxidant activity. Pyrolysis of BB generated CO2 while pyrolysis of FS generated H2. In summary, bovine bones and fish scales are promising precursors to concomitantly produce biochars with great adsorbent potential and oils with interesting characteristics

Benthic Foraminifera and Bacterial Activity as a Proxy for Environmental Characterization in Potengi Estuary, Rio Grande do Norte, Brazil

The aim of this study was to identify possible zonation patterns and assess the environmental impact on the Potengi River Estuary, Rio Grande do Norte State, through the distribution of benthic foraminifera associated to bacterial activity and abiotic parameters. Six sediment samples were collected from locations that presented clear signs of pollution. The environment was predominantly anaerobic and fermentation occurred at all sites. Forty-two species of foraminifera were identified. The dominant species were Ammonia tepida and Arenoparrella mexicana, which are known to be opportunistic, and able to adapt to rapidly changing conditions. CCA analyses showed that salinity and organic matter, followed by bacterial carbon, were more strongly linked to organism distribution in the Potengi River Estuary. Dissolved oxygen concentration, temperature and total organic matter were higher at the estuary mouth than at the other sites, creating favorable conditions for foraminiferal growth and allowing the faunistic succession on the upper estuary. As foraminifera assemblages when associated to environmental parameters can be used as efficient proxies for environmental diagnosis, these results suggest that the Potengi Estuary is under great stress from the surrounding urban development

Accelerating Cold Dark Matter Cosmology (ΩΛ≡0\Omega_{\Lambda}\equiv 0)

A new kind of accelerating flat model with no dark energy that is fully dominated by cold dark matter (CDM) is investigated. The number of CDM particles is not conserved and the present accelerating stage is a consequence of the negative pressure describing the irreversible process of gravitational particle creation. A related work involving accelerating CDM cosmology has been discussed before the SNe observations [Lima, Abramo & Germano, Phys. Rev. D53, 4287 (1996)]. However, in order to have a transition from a decelerating to an accelerating regime at low redshifts, the matter creation rate proposed here includes a constant term of the order of the Hubble parameter. In this case, $H_0$ does not need to be small in order to solve the age problem and the transition happens even if the matter creation is negligible during the radiation and part of the matter dominated phase. Therefore, instead of the vacuum dominance at redshifts of the order of a few, the present accelerating stage in this sort of Einstein-de Sitter CDM cosmology is a consequence of the gravitational particle creation process. As an extra bonus, in the present scenario does not exist the coincidence problem that plagues models with dominance of dark energy. The model is able to harmonize a CDM picture with the present age of the universe, the latest measurements of the Hubble parameter and the Supernovae observations.Comment: 9 pages, 6 figures, typos corrected, references added, discussion in Appendix B extende

Foraminíferos bentônicos e atividade bacteriana como ferramenta para análise ambiental no Estuário do Rio Pontegi, Rio Grande do Norte, Brasil

The aim of this study was to identify possible zonation patterns and assess the environmental impact on the Potengi River Estuary, Rio Grande do Norte State, through the distribution of benthic foraminifera associated to bacterial activity and abiotic parameters. Six sediment samples were collected from locations that presented clear signs of pollution. The environment was predominantly anaerobic and fermentation occurred at all sites. Forty-two species of foraminifera were identified. The dominant species were Ammonia tepida and Arenoparrella mexicana, which are known to be opportunistic, and able to adapt to rapidly changing conditions. CCA analyses showed that salinity and organic matter, followed by bacterial carbon, were more strongly linked to organism distribution in the Potengi River Estuary. Dissolved oxygen concentration, temperature and total organic matter were higher at the estuary mouth than at the other sites, creating favorable conditions for foraminiferal growth and allowing the faunistic succession on the upper estuary. As foraminifera assemblages when associated to environmental parameters can be used as efficient proxies for environmental diagnosis, these results suggest that the Potengi Estuary is under great stress from the surrounding urban development.Este estudo teve como objetivo estabelecer um modelo de zonação e avaliar o impacto ambiental sofrido pelo estuário do rio Potengi, estado do Rio Grande do Norte, através da distribuição das assembléias de foraminíferos associados à atividade bacteriana e a parâmetros físico-químicos. Seis amostras de sedimento foram coletadas em regiões que apresentavam algum tipo poluição aparente. Predominaram os processos bacterianos anaeróbicos principalmente sulfatoredução no estuário. Foram identificadas quarenta e duas espécies de foraminíferos. As espécies dominantes foram Ammonia tepida e Arenoparrella mexicana, que são conhecidas como oportunistas, pois se adaptam com facilidade as variações ambientais. A análise em CCA mostrou que a salinidade e a matéria orgânica, seguidos pelo carbono bacteriano, conduziram a distribuição dos organismos no estuário. A concentração de oxigênio, temperatura e matéria orgânica total foram mais altas na foz do que em outras estações, criando condições favoráveis ao crescimento de foraminíferos e permitiu uma sucessão faunística em direção ao estuário superior. Assembléias de foraminíferos quando associadas a parâmetros ambientais podem ser usadas como eficientes indicadores para o diagnostico ambiental. Os resultados sugeriram que o estuário do rio Potengi encontra-se sobre condições de grande estresse ambiental provocado pelo desenvolvimento urbano a sua volta

Optimally combining dynamical decoupling and quantum error correction

We show how dynamical decoupling (DD) and quantum error correction (QEC) can be optimally combined in the setting of fault tolerant quantum computing. To this end we identify the optimal generator set of DD sequences designed to protect quantum information encoded into stabilizer subspace or subsystem codes. This generator set, comprising the stabilizers and logical operators of the code, minimizes a natural cost function associated with the length of DD sequences. We prove that with the optimal generator set the restrictive local-bath assumption used in earlier work on hybrid DD-QEC schemes, can be significantly relaxed, thus bringing hybrid DD-QEC schemes, and their potentially considerable advantages, closer to realization.Comment: 6 pages, 1 figur