PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR LYMPHOMA PATIENTS: SINGLE CENTER EXPERIENCE

Amaç: Birinci sıra tedaviye yeterli yanıt vermeyen yada relaps olan Hodgkin ve Non-Hodgkin lenfomalı hastalarda ikinci sıra tedavi sonrası otolog periferik kök hücre(OKIT) destekli yüksek doz kemoterapi yaygın olarak kullanılmaktadır. Biz buçalışmada Dokuz Eylül Üniversitesi Tıp Fakültesi Hematoloji Bilim dalı tarafından2005-2009 yılları arasında izlenen ve periferik kök hücre nakli yapılan 45 lenfomahastasını sunmayı amaçladık.Gereç ve yöntemler: Hastaların yaşları 19-67 arasında ve yaş ortalamaları 38,87 idi.Tanılarına bakıldığında %24,4'ü Diffüz Büyük B hücreli NHL, %35,6'sı NodülerSklerozan Hodgkin Lenfoma, %17,8'i miks sellüler Hodgkin lenfoma, %8,9'u lenfoblastiklenfoma idi.Bulgular: Hastaların %90'ına OKIT destekli yüksek doz tedavi, %10'una ise allogeneikkök hücre nakli uygulandı. Nakil sonrası hastaların son yapılan değerlendirmelerinde45 hastanın 13'ünün komplet remisyonda, 2'sinin progresif hastalık, 2'sinin parsiyelyanıtlı, 3'ünün stabil hastalık olduğu görüldü. 12 hasta hastalık ilişkili, 2'si hastalık dışınedenlerle ve 11 hastada sepsis nedeni ile kaybedildi.Sonuç: Otolog periferik kök hücre destekli yüksek doz tedavi ile özellikle platin bazlıtedaviye yanıt veren lenfoma hasta gurubunda yüz güldürücü sonuçlar alınmaktadır.Objective: Peripheral Blood Stem Cell Transplantation (PBSCT) following intensiveconditioning chemotherapy has improved the survival in relapsed Hodgkin's disease(HD) and non- Hodgkin's lymphoma (NHL). In this study we aim to present 45relapsed refractory lymphoma patients who had peripheral blood stem celltransplantation and were observed between 2005 and 2009 by Dokuz Eylül UniversityFaculty of Medicine Hematology Department.Material and methods: The age range of 45 pateients that were included in this studywas between 19 and 67, and the mean age is 38,87... When we look at subtypes, 24.4%diffuse large B-cell NHL, 35.6% Nodular Sclerozan Hodgkin\\\'s Lymphoma, 17.8% mixed cellula rity Hodgkin\\\'s lymphoma, and 8.9% were diagnosed as lymphoblastic lymphoma.Results: 90% of the patients were treated with high-dose chemotherapy withautologous PBSCT, to the 10% of the pateients allogeneic PBSCT from full matchedrelatives was applied.. Recent evaluation of 45 patients, 13 patients were CR (28.9%), 2have progressive disease, 2 PR, 3 were classified as SD. Associated with the disease in12 patients, 2 of them for reasons other than illness, and 11 patients had died of sepsis.Conclusion: PBSCT following intensive conditioning chemotherapy has improved thesurvival in relapsed-refractory lymphoma patients

The Relationship between Exercise Capacity and Muscle Strength, Physical Activity, Fatigue and Quality of Life in Patients with Cancer Cachexia

Background: Exercise capacity is a significant determinant of mortality for cancer patients, so knowing the possible determinants of exercise capacity will produce physical and psychological benefits for individuals with cancer cachexia. Purpose: To investigate the relationship between exercise capacity on peripheric and respiratory muscle strength, physical activity, fatigue and quality of life in subjects with cancer cachexia. Methods: The study included 31 patients diagnosed with cancer cachexia. Functional capacity was assessed by 6-Minute Walk Test, hand grip strength and proximal muscle mass by hand dynamometer, respiratory muscle strength by the Maximum Expiratory Pressure and Maximum Inspiratory Pressure measurements, physical activity by International Physical Activity Questionnaire Short Form, fatigue by Brief Fatigue Inventory, and quality of life by EORT-QLQ-C30. The relationship between functional capacity and continuous independent variables was determined using Spearman’s or Pearson’s tests. Results: A strong positive correlation was observed between exercise capacity and expiratory muscle strength (r = 0.75, p < 0.001), activity level (r = 0.68, p < 0.001), and quality of life global health status (r = 0.74, p < 0.001). Conversely, a strong negative correlation was found between exercise capacity and fatigue severity (r = −0.64, p < 0.001). Conclusion: Higher exercise capacity in cancer cachexia patients is linked to reduced fatigue, improved respiratory muscle strength, increased physical activity levels, and enhanced quality of life. When designing rehabilitation programs or exercise interventions for individuals with cancer cachexia, it is crucial to assess their exercise capacity and tailor the programs accordingly