PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR LYMPHOMA PATIENTS: SINGLE CENTER EXPERIENCE

Amaç: Birinci sıra tedaviye yeterli yanıt vermeyen yada relaps olan Hodgkin ve Non-Hodgkin lenfomalı hastalarda ikinci sıra tedavi sonrası otolog periferik kök hücre(OKIT) destekli yüksek doz kemoterapi yaygın olarak kullanılmaktadır. Biz buçalışmada Dokuz Eylül Üniversitesi Tıp Fakültesi Hematoloji Bilim dalı tarafından2005-2009 yılları arasında izlenen ve periferik kök hücre nakli yapılan 45 lenfomahastasını sunmayı amaçladık.Gereç ve yöntemler: Hastaların yaşları 19-67 arasında ve yaş ortalamaları 38,87 idi.Tanılarına bakıldığında %24,4'ü Diffüz Büyük B hücreli NHL, %35,6'sı NodülerSklerozan Hodgkin Lenfoma, %17,8'i miks sellüler Hodgkin lenfoma, %8,9'u lenfoblastiklenfoma idi.Bulgular: Hastaların %90'ına OKIT destekli yüksek doz tedavi, %10'una ise allogeneikkök hücre nakli uygulandı. Nakil sonrası hastaların son yapılan değerlendirmelerinde45 hastanın 13'ünün komplet remisyonda, 2'sinin progresif hastalık, 2'sinin parsiyelyanıtlı, 3'ünün stabil hastalık olduğu görüldü. 12 hasta hastalık ilişkili, 2'si hastalık dışınedenlerle ve 11 hastada sepsis nedeni ile kaybedildi.Sonuç: Otolog periferik kök hücre destekli yüksek doz tedavi ile özellikle platin bazlıtedaviye yanıt veren lenfoma hasta gurubunda yüz güldürücü sonuçlar alınmaktadır.Objective: Peripheral Blood Stem Cell Transplantation (PBSCT) following intensiveconditioning chemotherapy has improved the survival in relapsed Hodgkin's disease(HD) and non- Hodgkin's lymphoma (NHL). In this study we aim to present 45relapsed refractory lymphoma patients who had peripheral blood stem celltransplantation and were observed between 2005 and 2009 by Dokuz Eylül UniversityFaculty of Medicine Hematology Department.Material and methods: The age range of 45 pateients that were included in this studywas between 19 and 67, and the mean age is 38,87... When we look at subtypes, 24.4%diffuse large B-cell NHL, 35.6% Nodular Sclerozan Hodgkin\\\'s Lymphoma, 17.8% mixed cellula rity Hodgkin\\\'s lymphoma, and 8.9% were diagnosed as lymphoblastic lymphoma.Results: 90% of the patients were treated with high-dose chemotherapy withautologous PBSCT, to the 10% of the pateients allogeneic PBSCT from full matchedrelatives was applied.. Recent evaluation of 45 patients, 13 patients were CR (28.9%), 2have progressive disease, 2 PR, 3 were classified as SD. Associated with the disease in12 patients, 2 of them for reasons other than illness, and 11 patients had died of sepsis.Conclusion: PBSCT following intensive conditioning chemotherapy has improved thesurvival in relapsed-refractory lymphoma patients

May reorder point help under disruptions?

We study a continuous-review inventory problem of a retailer observing constant deterministic demand and ordering from a supplier. This is an extension of Economic Order Quantity model (EOQ), in which both supplier and retailer are subject to random disruptions. The supplier is assumed to be at two states, which are available and unavailable. When the retailer is disrupted, all on-hand inventory is destroyed, but the retailer recovers immediately to serve customers. All unsatisfied demand at retailer is assumed to be lost. We create a mathematical model to determine optimal parameters of an order-up-to type policy for the retailer and investigate the importance of a non-zero reorder point for the retailer. With computational experiments, we identify when a non-zero reorder point is cost saving, and compare our solution with classical EOQ

Retesting the psychometric characteristics of the European cancer research and treatment organization’s quality of life questionnaire palliative care 15 Turkish version (EQRTC QLQ C15-PAL) and evaluating the influencing factors

Purpose: The study aimed to retest the reliability and validity of the European Organization for Research and Treatment of Cancer-Core Quality of Life-15 Items Questionnaire for Palliative Care (EQRTC QLQ-C15-PAL) for the Turkish society and examine the influencing factors. Methods: The study was conducted in cancer patients who applied palliative treatment in the Dokuz Eylul University Oncology Institute Medical Oncology Division between May of 2014 and January of 2015. The demographic data collection form, performance status, and the EQRTC QLQ-C15-PAL scale were employed in order to gather data. Results: A total of 164 patients completed the study. The total Cronbach's alpha value for the scale was 0.794. The mean scores including the overall questionnaire, and subscales, which were calculated after two measurements conducted at an interval of three weeks, presented a statistically significant difference (p < 0.01). Patients with higher and lower ECOG scores had significant differences in terms of total QLQ-C15-PAL questionnaire scores as well as its subscales of physical, emotional functioning (PF, EF), and fatigue (FA) (p < 0.05). The statistically significant differences between patients' ECOG scores and QLQ-C15-PAL total score, and PF, EF, FA, and pain (PA) scores were 0.375, 0.439, 0.245, and 0.221, respectively (p < 0.001). The QLQ-C15-PAL questionnaire is able to measure 94.0% of the factors measured by the QLQ-C30-PAL. The variables included in the model affected the patients' quality of life to the extent of 44.0%. Conclusion: It has been shown that the scale is a valid/reliable instrument to detect the quality of life of Turkish cancer patients. Keywords: Cancer, Palliative care, Quality of lif

Evaluation of sleep disorders in cancer patients based on Pittsburgh Sleep Quality Index

Insomnia, poor sleep quality and short sleep durations are the most common problems seen in cancer patients. More studies are needed about sleep disorders in cancer patients. In our study, we aimed to investigate the prevalence of sleep disorders and the impact of these problems on the quality of life in cancer patients. Pittsburgh Sleep Quality Index (PSQI) was given to a total of 314 patients. The psychometric evaluation of the Turkish version of PSQI in cancer patients revealed that 127 (40.4%) patients had global PSQI scores >5, indicating poor sleep quality. There was no statistically significant relationship between PSQI scores and sexuality, marital status, cancer stage and chemotherapy type (P > 0.05); while the patients with bone and visceral metastasis had much lower PSQI scores (P = 0.006). Patients with Eastern Cooperative Oncology Group performance scores of 3 or more had also significantly lower PSQI scores (P = 0.02). In conclusion, PSQI questionnaire may be used to evaluate the sleep disorders in cancer patients. Consistent use of multi-item measures such as PSQI with established reliability and validity would improve our understanding of difficulties experienced by cancer patients with chronic insomnia

The Relationship between Exercise Capacity and Muscle Strength, Physical Activity, Fatigue and Quality of Life in Patients with Cancer Cachexia

Background: Exercise capacity is a significant determinant of mortality for cancer patients, so knowing the possible determinants of exercise capacity will produce physical and psychological benefits for individuals with cancer cachexia. Purpose: To investigate the relationship between exercise capacity on peripheric and respiratory muscle strength, physical activity, fatigue and quality of life in subjects with cancer cachexia. Methods: The study included 31 patients diagnosed with cancer cachexia. Functional capacity was assessed by 6-Minute Walk Test, hand grip strength and proximal muscle mass by hand dynamometer, respiratory muscle strength by the Maximum Expiratory Pressure and Maximum Inspiratory Pressure measurements, physical activity by International Physical Activity Questionnaire Short Form, fatigue by Brief Fatigue Inventory, and quality of life by EORT-QLQ-C30. The relationship between functional capacity and continuous independent variables was determined using Spearman’s or Pearson’s tests. Results: A strong positive correlation was observed between exercise capacity and expiratory muscle strength (r = 0.75, p < 0.001), activity level (r = 0.68, p < 0.001), and quality of life global health status (r = 0.74, p < 0.001). Conversely, a strong negative correlation was found between exercise capacity and fatigue severity (r = −0.64, p < 0.001). Conclusion: Higher exercise capacity in cancer cachexia patients is linked to reduced fatigue, improved respiratory muscle strength, increased physical activity levels, and enhanced quality of life. When designing rehabilitation programs or exercise interventions for individuals with cancer cachexia, it is crucial to assess their exercise capacity and tailor the programs accordingly