28 research outputs found
Endogenous sexual steroids and gonadotrophins in women with or without endometrial carcinoma: a comparative clinical study
Objective:To analyze the levels of endogenous sexual steroids and gonadotrophin in women with and without endometrial cancer. Methodology:We developed a clinical comparative study on 20 postmenopausal women with endometrial cancer and 20 postmenopausal women without endometrial cancer. The age, the postmenopausal time and the index of body mass were used as matching variables. The plasma levels of the endogenous sexual steroids were measured using radioimmunoassay and immunoenzymatic methods. For the statistic analysis we used the Student's t test. Results: The levels of androstenedione (A), total testosterone (t) and free testosterone (TL) were higher in the women with endometrial cancer, and those of the luteinic hormone (LH) were significantly lower values in these women. We also observed that the ratio (E1/A) showed significantly lower in the group of women with cancer, while the ratio (E2/E1) did not present any differences between groups. Conclusions: We emphasize the potentiality of sexual steroids and gonadotrophins in the genesis of endometrial adenocarcinoma in postmenopausal women.Objetivo: analisar os nĂveis dos esterĂłides sexuais endĂłgenos e gonadotrofinas em mulheres com e sem cĂąncer de endomĂ©trio. MĂ©todos: foi realizado estudo clĂnico-comparativo com 20 mulheres na pĂłs-menopausa com cĂąncer de endomĂ©trio e 20 mulheres na pĂłs-menopausa, sem cĂąncer de endomĂ©trio. A idade, o tempo de menopausa e o Ăndice de massa corpĂłrea foram utilizados como variĂĄveis de emparelhamento. Os nĂveis plasmĂĄticos dos esterĂłides sexuais endĂłgenos foram medidos por mĂ©todos de radioimunoensaio e imunoenzimĂĄtico. Para anĂĄlise estatĂstica utilizamos o teste t de Student. Resultados: os nĂveis de androstenediona (A), testosterona total (t) e testosterona livre (TL) foram mais elevados nas mulheres com cĂąncer de endomĂ©trio e os nĂveis de hormĂŽnio luteinizante (LH) foram significativamente menores nessas mulheres. TambĂ©m observamos que a razĂŁo (E1/A) mostrou valores significativamente menores no grupo de mulheres com cĂąncer, ao passo que a razĂŁo (E2/E1) nĂŁo apresentou diferenças nos dois grupos. ConclusĂ”es: destacamos a potencialidade dos esterĂłides sexuais e gonadotrofinas na gĂȘnese do adenocarcinoma de endomĂ©trio em mulheres na pĂłs-menopausa.26727
Foliar phenolic compounds of ten wild species of Verbenacea as antioxidants and specific chemomarkers
Perfil de contaminação por Staphylococcus e suas enterotoxinas e monitorização das condiçÔes de higiene em uma linha de produção de queijo de coalho
Performance, carcass characteristics and non-carcass components of Texel Ă Santa InĂȘs lambs fed fat sources and monensin
Vitamin B-6 Status In Unsupplemented Pregnant Women Is Associated Positively With Serum Docosahexaenoic Acid And Inversely With The N-6-to-n-3 Fatty Acid Ratio
Background: Vitamin B-6-deficient diets decrease plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) concentrations in healthy adults. These fatty acids (FAs) are important for fetal neurodevelopment, but the relation between vitamin B-6 status and circulating polyunsaturated FAs (PUFAs) during pregnancy is unknown. Objective: We sought to assess the relation between plasma pyridoxal 5' phosphate (PLP; the active form of vitamin B-6) and serum DHA, EPA, AA, linoleic acid, eicosadienoic, and a-linolenic acid concentrations during pregnancy. Methods: A prospective cohort study in 186 healthy pregnant Brazilian women (aged 20-40 y) who were not using supplements was conducted in Rio de Janeiro, Brazil. Participants were enrolled in the first trimester of pregnancy (5-13 gestational weeks) and were followed up twice between 20-26 and 30-36 wk of gestation. Longitudinal linear mixed-effects regression models were used to evaluate the associations between 1) first-trimester PLP and PUFA concentrations across pregnancy and 2) ÎPLP (i.e., difference between third- and first-trimester plasma PLP concentrations) and PUFA concentrations across pregnancy. Models were adjusted for gestational week, first-trimester body mass index, smoking habit, and dietary intakes of vitamin B-6, fish, total fat, and PUFAs. Results: Plasma PLP concentrations (median, IQR) substantially declined during pregnancy from 35.8 nmol/L (28.6-44.3 nmol/L) in the first trimester to 21.0 nmol/L (15.8-26.3 nmol/L) in the second trimester, and 16.8 nmol/L (12.9-20.3 nmol/L) in the third trimester (both P < 0.0001). Changes in plasma PLP concentrations across trimesterswere positively associated with serum DHA concentrations (ÎČ = 0.252, P = 0.012) and inversely associatedwith serumn-6-to-n-3 (Ï-6-to-Ï-3) FA ratio (b =20.010; P = 0.015), after adjustments for confounders. Conclusions: Maternal vitamin B-6 status during pregnancywas positively associated with the circulating concentration of DHA and inversely associated with n-6:n-3 FAs in Brazilian women who were not taking vitamin supplements. Further study is required to determine the impact of poor vitamin B-6 status on fetal neurodevelopment. © 2017 American Society for Nutrition.147217017
EsterĂłides sexuais e gonadotrofinas em mulheres com e sem carcinoma de endomĂ©trio: um estudo clĂnico comparativo
Objetivo: analisar os nĂveis dos esterĂłides sexuais endĂłgenos e gonadotrofinas em mulheres com e sem cĂąncer de endomĂ©trio. MĂ©todos: foi realizado estudo clĂnico-comparativo com 20 mulheres na pĂłs-menopausa com cĂąncer de endomĂ©trio e 20 mulheres na pĂłs-menopausa, sem cĂąncer de endomĂ©trio. A idade, o tempo de menopausa e o Ăndice de massa corpĂłrea foram utilizados como variĂĄveis de emparelhamento. Os nĂveis plasmĂĄticos dos esterĂłides sexuais endĂłgenos foram medidos por mĂ©todos de radioimunoensaio e imunoenzimĂĄtico. Para anĂĄlise estatĂstica utilizamos o teste "t" de Student. Resultados: os nĂveis de androstenediona (A), testosterona total (t) e testosterona livre (TL) foram mais elevados nas mulheres com cĂąncer de endomĂ©trio e os nĂveis de hormĂŽnio luteinizante (LH) foram significativamente menores nessas mulheres. TambĂ©m observamos que a razĂŁo (E1/A) mostrou valores significativamente menores no grupo de mulheres com cĂąncer, ao passo que a razĂŁo (E2/E1) nĂŁo apresentou diferenças nos dois grupos. ConclusĂ”es: destacamos a potencialidade dos esterĂłides sexuais e gonadotrofinas na gĂȘnese do adenocarcinoma de endomĂ©trio em mulheres na pĂłs-menopausa