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Bacteria herald a new era of gene editing.
The demonstration that nucleases guided by bacterial RNA can disrupt human genes represents a landmark in the rapidly developing field of genome engineering
Beyond the genome and into the clinic.
A report of BioMed Central's third annual Beyond the Genome conference, held at Harvard Medical School, Boston, September 27-29, 2012
The body in the library: adventures in realism
This essay looks at two aspects of the virtual āmaterial worldā of realist fiction: objects encountered by the protagonist and the latterās body. Taking from Sartre two angles on the realist pact by which readers agree to lend
their bodies, feelings, and experiences to the otherwise ālanguishing signsā of the text, it goes on to examine two sets of first-person fictions published between 1902 and 1956 ā first, four modernist texts in which banal objects defy and then gratify the protagonist, who ends up ready and almost able to write; and, second, three novels in which the body of the protagonist is indeterminate in its sex, gender, or sexuality. In each of these cases, how do we as readers make texts work for us as āan adventure of the bodyā
Analysis of AIS Data of the Recluse Oil Field, Recluse, Wyoming
Airborne Imaging Spectrometer (AIS) data were flown over the Recluse, Wyoming oil field on September 9, 1984. Processing software was developed at Earth Satellite Corporation (EarthSat) for interactive analysis of the AIS data. EarthSat's AIS processing capabilities include destriping, solar irradiance corrections, residual calculations, geometric resampling, equal energy normalization, interactive spectral classifications and a variety of compressive algorithms to reduce the data to 8-bit format with a minimum of information loss. The in-house photolab facilities of EarthSat can routinely produce high-quality color renditions of the enhanced AIS data. A total of 80 lithologic samples were collected under the AIS flight lines. Correlation (within the atmospheric windows) between the laboratory and the AIS spectra of sample sites was generally poor. Reasonable correlation was only possible in large, freshly plowed fields. Mixed pixels and contrast between the natural and sample's surfaces were believed responsible for the poor correlation. Finally, a drift of approximately three channels was observed in the diffraction grating position within the 1.8 to 2.1 micron quadrant
An analytical study of electric vehicle handling dynamics
Hypothetical electric vehicle configurations were studied by applying available analytical methods. Elementary linearized models were used in addition to a highly sophisticated vehicle dynamics computer simulation technique. Physical properties of specific EV's were defined for various battery and powertrain packaging approaches applied to a range of weight distribution and inertial properties which characterize a generic class of EV's. Computer simulations of structured maneuvers were performed for predicting handling qualities in the normal driving range and during various extreme conditions related to accident avoidance. Results indicate that an EV with forward weight bias will possess handling qualities superior to a comparable EV that is rear-heavy or equally balanced. The importance of properly matching tires, suspension systems, and brake system front/rear torque proportioning to a given EV configuration during the design stage is demonstrated
Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.
Transcription factor-DNA interactions are some of the most important processes in biology because they directly control hereditary information. The targets of most transcription factor are unknown. In this report, we introduce Bind-n-Seq, a new high-throughput method for analyzing protein-DNA interactions in vitro, with several advantages over current methods. The procedure has three steps (i) binding proteins to randomized oligonucleotide DNA targets, (ii) sequencing the bound oligonucleotide with massively parallel technology and (iii) finding motifs among the sequences. De novo binding motifs determined by this method for the DNA-binding domains of two well-characterized zinc-finger proteins were similar to those described previously. Furthermore, calculations of the relative affinity of the proteins for specific DNA sequences correlated significantly with previous studies (R(2 )= 0.9). These results present Bind-n-Seq as a highly rapid and parallel method for determining in vitro binding sites and relative affinities
Testing the Hubble Law with the IRAS 1.2 Jy Redshift Survey
We test and reject the claim of Segal et al. (1993) that the correlation of
redshifts and flux densities in a complete sample of IRAS galaxies favors a
quadratic redshift-distance relation over the linear Hubble law. This is done,
in effect, by treating the entire galaxy luminosity function as derived from
the 60 micron 1.2 Jy IRAS redshift survey of Fisher et al. (1995) as a distance
indicator; equivalently, we compare the flux density distribution of galaxies
as a function of redshift with predictions under different redshift-distance
cosmologies, under the assumption of a universal luminosity function. This
method does not assume a uniform distribution of galaxies in space. We find
that this test has rather weak discriminatory power, as argued by Petrosian
(1993), and the differences between models are not as stark as one might expect
a priori. Even so, we find that the Hubble law is indeed more strongly
supported by the analysis than is the quadratic redshift-distance relation. We
identify a bias in the the Segal et al. determination of the luminosity
function, which could lead one to mistakenly favor the quadratic
redshift-distance law. We also present several complementary analyses of the
density field of the sample; the galaxy density field is found to be close to
homogeneous on large scales if the Hubble law is assumed, while this is not the
case with the quadratic redshift-distance relation.Comment: 27 pages Latex (w/figures), ApJ, in press. Uses AAS macros,
postscript also available at
http://www.astro.princeton.edu/~library/preprints/pop682.ps.g
Ready or Not? Protecting the Public's Health in the Age of Bioterrorism, 2004
Examines ten key indicators to evaluate state preparedness to respond to bioterrorist attacks and other public health emergencies. Evaluates the federal government's role and performance, and offers recommendations for improving readiness
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