17 research outputs found

    Diving into the vertical dimension of elasmobranch movement ecology

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    This is the final version. Available on open access from the American Association for the Advancement of Science via the DOI in this recordData and materials availability: Processed data and code used in the analysis are accessible from the Zenodo Repository: 10.5281/zenodo.6885455Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements.Bertarelli FoundationResearch EnglandMoore FoundationPackard FoundationInstituto Politecnico NacionalDarwin InitiativeGeorgia AquariumRolex Awards for EnterpriseWhitley Fund for Natur

    Continuous Pharmaceutical Crystallization from Solution

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    The pharmaceutical industry has traditionally employed exclusively batch manufacturing for drug substances. The current trend is to explore continuous manufacturing; this chapter described the process by which a continuous pharmaceutical crystallization can be developed

    Evaluating the Business Case for Continuous Manufacturing of Pharmaceuticals: A Supply Network perspective

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    This chapter addresses the challenges of evaluating the business case for continuous manufacturing of pharmaceuticals, looking beyond traditional technical assessments made at the unit operations or individual production facility level. It provides an overview of key concepts, approaches and tools for the early assessment of supply network configuration opportunities enabled by continuous production processing interventions. Multiple levels of analysis are considered with the aid of examples based on major UK research programmes on continuous production process technologies. Particular emphasis is placed on the potential for achieving enhanced product flexibility (in terms of volume and variety) and depending on scale, the optimum number and location of manufacturing operations to support speed to market and system-level cost benefits. In the case of multiple manufacturing operations using continuous production process technologies, where production facility replication through digital twins is becoming a key enabler, the chapter sets out a supply network design and analysis approach that evaluates the commercial and operational viability of alternative manufacturing supply network scenarios
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