An approach for computing AS/R systems travel times in a class-based storage configuration

This study provides an approach to compute the travel time for AS/R systems in a class-based storage environment. A regression analysis is completed in order to define the importance of the key predictors taken into account and to propose a formulation of travel times. The results show the reliability of the model and allow to evaluate the travel time through the identification of a complete list of predictors. The proposed approach supports managers in theex-ante definition of travel times for a warehouse. A correct evaluation of travel times enables a better monitoring of the performance of warehouse operations and can support practitioners in the choice of the configuration not only in terms of kind of cycle, but also from a policy assignment perspective. From a theoretical point of view, this work can be considered as an attempt to refine the existing methods to compute travel times

Cuantificación simultánea de colorantes en bebidas deportivas utilizando espectroscopia visible y PLS-1

En este trabajo se propone un nuevo procedimiento para la cuantificación de cuatro colorantes artificiales: rojo allura, azul brillante, tartrazina y amarillo ocaso, presentes en bebidas hidratantes de la marca Gatorade y Powerade. Se aplico espectroscopía visible y calibración multivariada. Los datos fueron tratados con el programa Matlab y la rutina MVC1 aplicando el método PLS-1. Los resultados de las predicciones aplicando este nuevo método, se compararon estadísticamente con los obtenidos aplicando el método de referencia (cromatografía líquida), en todos los casos los resultados fueron comparables. La desventaja es que el amarillo ocaso no pudo ser cuantificado por este método, aunque su presencia no interfiere con la determinación de los otros tres colorantes. Puede concluirse que este método es fácilmente aplicable para el control de calidad de colorantes en bebidas comerciales en laboratorios de baja complejidad, sin necesidad de recurrir a técnicas separativas y reactivos contaminantes.Fil: Rodríguez, María Celeste. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Schenone, Agustina Violeta. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Sobrero, M. S.. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Marsili, N. R. . Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentin

Airborne Sound Power Levels and Spectra of Noise Sources in Port Areas

Airborne port noise has historically suffered from a lack of regulatory assessment compared to other transport infrastructures. This has led to several complaints from citizens living in the urban areas surrounding ports, which is a very common situation, especially in countries facing the Mediterranean sea. Only in relatively recent years has an effort been made to improve this situation, which has resulted in a call for and financing of numerous international cooperation research projects, within the framework of programs such as EU FP7, H2020, ENPI-CBC MED, LIFE, and INTERREG. These projects dealt with issues and aspects of port noise, which is an intrinsically tangled problem, since several authorities and companies operate within the borders of ports, and several different noise sources are present at the same time. In addition, ship classification societies have recently recognized the problem and nowadays are developing procedures and voluntary notations to assess the airborne noise emission from marine vessels. The present work summarizes the recent results of research regarding port noise sources in order to provide a comprehensive database of sources that can be easily used, for example, as an input to the noise mapping phase, and can subsequently prevent citizens' exposure to noise

Guidelines for a common port noise impact assessment: the ANCHOR LIFE project

The paper reports the main contents of the guidelines developed in the framework of the project ANCHOR, acronym of Advanced Noise Control strategies in HarbOuR, which is a European Project funded as part of the announcement Life 2017. The guidelines represent an updated version of those elaborated in the NoMEPorts project named 'Good Practice Guide on Port Area Noise Mapping and Management'; the aim is to define a common approach in port noise monitoring and assessment, considering the outcomes of previous EU funded projects and the algorithms defined by the European Directive 2015/996, in order to produce Port Noise Impact Assessments to be included in ports Environmental Management Systems (EMS). The procedures described in the guidelines will guide professionals in organizing and managing geographical data, in characterizing noise sources and defining, for each of them, the correct noise emission power level, in evaluating noise propagation and people exposure to noise and, finally, in selecting the most efficient mitigation action by means of a cost benefit analysis. Moreover, the paper reports the results of a comparison between noise mapping outcomes obtained using the new noise mapping algorithms defined by the 2015/996 Directive and the old 2002/49/EC Annex II ones; especially at long distances from the source the differences between the two methodologies are not negligible

l-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain

Background and Aim: l-Acetyl-carnitine (LAC) exerts an energetic effect on nerves and muscles. Recently, preclinical experiments have demonstrated a central anti-nociceptive action. Objective: Our objective was to assess the effects of LAC on neuroprotection, pain, and function in carpal tunnel syndrome (CTS), a very frequent chronic compressive neuropathy. Methods: In a multicentre, examiner-blinded, clinical and neurophysiological 4-month study, we enrolled 82 patients and examined 120 hands with CTS of mild to moderate severity. Patients were assessed at baseline and 10, 60 and 120\uc2 days after treatment with LAC 500\uc2 mg twice daily (BID). All patients underwent a conduction study of the median nerve, the Boston Carpal Tunnel Questionnaire (BCTQ) and the Neuropathic Pain Symptom Inventory (NPSI). The primary endpoint was the sensory conduction velocity (SCV) of the median nerve. Results: The primary endpoint was met, with significant improvement of the SCV (P\uc2&nbsp

Sweet cherry extract as permeation enhancer of tyrosine kinase inhibitors: a promising prospective for future oral anticancer therapies

Although patients would rather oral therapies to injections, the gastrointestinal tract's low permeability makes this method limiting for most compounds, including anticancer drugs. Due to their low bioavailability, oral antitumor therapies suffer from significant variability in pharmacokinetics and efficacy. The improvement of their pharmacokinetic profiles can be achieved by a new approach: the use of natural extracts enriched with polyphenolic compounds that act as intestinal permeability enhancers. Here, we propose a safe sweet cherry extract capable of enhancing oral absorption. The extract was characterized by the HPLC-UV/MS method, evaluated for in vitro antioxidant activity, safety on the Caco-2 cell line, and as a potential permeation enhancer. The sweet cherry extract showed a high antioxidant capacity (ABTS and DPPH assays were 211.74 and 48.65 mu mol of Trolox equivalent/g dried extract, respectively), high content of polyphenols (8.44 mg of gallic acid per gram of dry extract), and anthocyanins (1.80 mg of cyanidin-3-glucoside equivalent per g of dry extract), reassuring safety profile (cell viability never lower than 98%), and a significant and fully reversible ability to alter the integrity of the Caco-2 monolayer (+81.5% of Lucifer yellow permeability after 2 h). Furthermore, the ability of the sweet cherry extract to improve the permeability (P-app) and modify the efflux ratio (ER) of reference compounds (atenolol, propranolol, and dasatinib) and selected pyrazolo[3,4-d]pyrimidine derivatives was investigated. The obtained results show a significant increase in apparent permeability across the Caco-2 monolayer (tripled and quadrupled in most cases), and an interesting decrease in efflux ratio when compounds were co-incubated with sweet cherry extract

Detection of influenza A(H1N1)pdm09 virus in a patient travelling from Shanghai to Italy in July 2018: An uncommon clinical presentation in a non-seasonal period

Influenza is one of the most common infectious diseases in travellers, especially in those returning from subtropical and tropical regions. In late June 2018 an influenza A(H1N1)pdm09 virus infection was diagnosed in a 36-years-old man, returned from a travel in Shanghai and hospitalized at the Ospedale Policlinico San Martino, Genoa, Italy, with a diagnosis of fever and an uncommon clinical presentation characterised by a persistent leukopenia. Phylogenetic analysis revealed a closeness with influenza A(H1N1)pdm09 strains circulating in the US in May-June 2018. Prompt recognition of influenza infection led to a proper case management, demonstrating the crucial role of the continuous influenza surveillance programme