Evidence for anisotropic motion of the clouds in broad-line regions of BL Lacertae objects

The masses of central massive black holes in BL Lac objects are estimated from their host galaxy absolute magnitude at R-band by using the empirical relation between absolute magnitude of host galaxy and black hole mass. Only a small fraction of BL Lac objects exhibit weak broad-line emission, and we derive the sizes of the broad-line regions (BLRs) in these BL Lac objects from the widths of their broad emission lines on the assumption of the clouds being virilized in BLRs. It is found that the sizes of the BLRs in these sources are usually 2-3 orders of magnitude larger than that expected by the empirical correlation between BLR size and optical luminosity defined by a sample of Seyfert galaxies and quasars. We discuss a variety of possibilities and suggest it may probably be attributed to anisotropic motion of the BLR clouds in these BL Lac objects. If the BLR geometry of these sources is disk-like, the viewing angles between the axis and the line of sight are in the range of 2-12 degrees, which is consistent with the unification schemes.Comment: 5 pages, accepted for publication in Ap

HST Observations of the Optical Jets of PKS 0521-365, 3C371, and PKS 2201+044

HST observations have led to the discovery of the optical counterpart of the radio jet of PKS 2201+044, and to a detailed analysis of the optical jets of PKS 0521-365 and 3C371. At HST spatial resolution these jets are well resolved, displaying knotty morphologies. When compared with radio maps of appropriate resolution, a clear one-to-one correspondence between optical and radio structures is found, showing that all detected optical structures are indeed related to the radio synchrotron emission. Photometry of the brightest knots shows that the radio-to-optical spectral index and the derived intensity of the equipartition magnetic field are approximately constant along the jet. Thus, present observations suggest that the electron energy distribution does not change significantly all along the jet.Comment: Accepted for publications on the Astrphysical Journal. Contains 14 pages and 5 figure

Gastrointestinal tumors: Phytochemical and drug combinations targeting the hallmarks of cancer

Cancer is a worldwide burden resulting in millions of deaths each year. In particular, gastrointestinal tumors are life-threatening malignancies and one of the leading reasons for death in developed countries. Phytochemicals can be found in grains, vegetables, fruits and several foods. Many phytochemicals, such as curcumin, genistein, luteolin, vitexin-2-O-xyloside, avenanthramides, quercetin, epigallocatechin-3-gallate (EGCG), resveratrol, sulforaphane, piperine and thymoquinone have been used in combination with different chemotherapeutic agents for their synergistic anticancer effects against various forms of cancer. In this review, we describe the antitumor properties and biological effects of combinations of phytochemicals and anticancer drugs against gastrointestinal tumors: colon cancer, gastric cancer, liver cancer, pancreatic cancer. We focus on the molecular pathways, oncoproteins and tumor suppressors modulated by the combination of phytochemicals with antitumor drugs and on the biomarkers of the hallmarks of cancer influenced by these therapeutic strategies in cancer cell lines, xenograft models and clinical trials. The increased knowledge of biomarkers and molecular pathways regulated by the combination of phytochemicals and conventional anticancer drugs in both in vitro and in vivo models will remarkably improve the efficacy of these therapeutic strategies against gastrointestinal tumors in future innovative clinical applications

Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy?

Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating contracture and deformities of fingers and hands. The present study was designed to characterize pro-inflammatory cytokines and growth factors involved in the pathogenesis, progression and recurrence of this disease, in order to find novel targets for alternative therapies and strategies in controlling DC. The expression of pro-inflammatory cytokines and of growth factors was detected by immunohistochemistry in fibrotic nodules and normal palmar fascia resected respectively from patients affected by DC and carpal tunnel syndrome (CTS; as negative controls). Reverse transcription (RT)-PCR analysis and immunofluorescence were performed to quantify the expression of transforming growth factor (TGF)-β1, interleukin (IL)-1β and vascular endothelial growth factor (VEGF) by primary cultures of myofibroblasts and fibroblasts isolated from Dupuytren's nodules. Histological analysis showed high cellularity and high proliferation rate in Dupuytren's tissue, together with the presence of myofibroblastic isotypes; immunohistochemical staining for macrophages was completely negative. In addition, a strong expression of TGF-β1, IL-1β and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared with control tissues. These results were confirmed by RT-PCR and by immunofluorescence in pathological and normal primary cell cultures. These preliminary observations suggest that TGF-β1, IL-1β and VEGF may be considered potential therapeutic targets in the treatment of Dupuytren's disease (DD)

The circum-galactic medium of quasars: CIV absorption systems

We investigate the properties of the circumgalactic gas in the halo of quasar host galaxies from CIV absorption line systems. Optical spectroscopy of closely aligned pairs of quasars (projected distance \leq 200 kpc) obtained at the Gran Telescopio Canarias is used to investigate the distribution of the absorbing gas for a sample of 18 quasars at z \sim 2. We found that the detected absorption systems of EW \geq 0.3Ang associated with the foreground QSO are revealed up to 200 kpc from the center of the host galaxy. The structure of the absorbing gas is rather patchy with a covering fraction of the gas that quickly decreases beyond 100 kpc. These results are in qualitative agreement with those found for the lower ionisation metal Mg II 2800 Ang.Comment: Very minor revision . Accepted for publication in MNRA

Virial theorem in clusters of galaxies with MOND

A specific modification of Newtonian dynamics known as MOND has been shown to reproduce the dynamics of most astrophysical systems at different scales without invoking non-baryonic dark matter (DM). There is, however, a long-standing unsolved problem when MOND is applied to rich clusters of galaxies in the form of a deficit (by a factor around two) of predicted dynamical mass derived from the virial theorem with respect to observations. In this article we approach the virial theorem using the velocity dispersion of cluster members along the line of sight rather than using the cluster temperature from X-ray data and hydrostatic equilibrium. Analytical calculations of the virial theorem in clusters for Newtonian gravity+DM and MOND are developed, applying pressure (surface) corrections for non-closed systems. Recent calibrations of DM profiles, baryonic ratio and baryonic ($\beta$ model or others) profiles are used, while allowing free parameters to range within the observational constraints. It is shown that solutions exist for MOND in clusters that give similar results to Newton+DM -- particularly in the case of an isothermal $\beta$ model for $\beta =0.55-0.70$ and core radii $r_c$ between 0.1 and 0.3 times $r_{500}$ (in agreement with the known data). The disagreements found in previous studies seem to be due to the lack of pressure corrections (based on inappropriate hydrostatic equilibrium assumptions) and/or inappropriate parameters for the baryonic matter profiles.Comment: accepted to be published in MNRA

The HST Survey of BL Lacertae Objects. I. Surface Brightness Profiles, Magnitudes, and Radii of Host Galaxies

We report on a large HST imaging survey of BL Lac objects, at spatial resolution ~10 times better than previous ground-based surveys. We focus on data reduction and analysis, describing the procedures used to model the host galaxy surface brightness radial profiles. A total of 69 host galaxies were resolved out of 110 objects observed, including almost all sources at z < 0.5. We classify them morphologically by fitting with either an exponential disk or a de~Vaucouleurs profile; when one fit is preferred over the other, in 58 of 69 cases, it is invariably the elliptical morphology. This is a very strong result given the large number of BL Lac objects, the unprecedented spatial resolution, and the homogeneity of the data set. With the present reclassification of the host galaxy of 1418+546 as an elliptical, there remain no undisputed examples of a disk galaxy hosting a BL Lac nucleus. This implies that, at 99% confidence, fewer than 7% of BL Lacs can be in disk galaxies. The apparent magnitude of the host galaxies varies with distance as expected if the absolute magnitudes are approximately the same, with a spread of +-1 mag, out to redshift z < 0.5. At larger redshifts, only 6 of 23 BL Lacs are resolved so the present data do not constrain possible luminosity evolution of the host galaxies. The collective Hubble diagram for BL Lac host galaxies and radio galaxies strongly supports their unification.Comment: Accepted for publication on ApJS. 43 pages. 10 figures. Figure 1 can also be downloaded from http://icarus.stsci.edu/~scarpa/tmp/hst_figure1.ta

ASCA and contemporaneous ground-based observations of the BL Lacertae objects 1749+096 and 2200+420 (BL Lac)

We present ASCA observations of the radio-selected BL Lacertae objects 1749+096 (z=0.32) and 2200+420 (BL Lac, z=0.069) performed in 1995 Sept and Nov, respectively. The ASCA spectra of both sources can be described as a first approximation by a power law with photon index Gamma ~ 2. This is flatter than for most X-ray-selected BL Lacs observed with ASCA, in agreement with the predictions of current blazar unification models. While 1749+096 exhibits tentative evidence for spectral flattening at low energies, a concave continuum is detected for 2200+420: the steep low-energy component is consistent the high-energy tail of the synchrotron emission responsible for the longer wavelengths, while the harder tail at higher energies is the onset of the Compton component. The spectral energy distributions from radio to gamma-rays are consistent with synchrotron-self Compton emission from a single homogeneous region shortward of the IR/optical wavelengths, with a second component in the radio domain related to a more extended emission region. For 2200+420, comparing the 1995 Nov state with the optical/GeV flare of 1997 July, we find that models requiring inverse Compton scattering of external photons provide a viable mechanism for the production of the highest (GeV) energies during the flare. An increase of the external radiation density and of the power injected in the jet can reproduce the flat gamma-ray continuum observed in 1997 July. A directly testable prediction of this model is that the line luminosity in 2200+420 should vary shortly after (~1 month) a non-thermal synchrotron flare.Comment: 28 pages,6 figures, 5 tables; LaTeX document. accepted for publication in the Astrophysical Journa