DAPSONE HYPERSENSITIVITY SYNDROME: A COMPLICATION OF DAPSONE THERAPY

Dapsone is chemically sulfonamide with its leprostatic mechanism used in the treatment of Hansen’s disease. It is one of the safest drugs in leprosy patients. Apart from its safety, it is associated with various adverse effects such as hemolytic anemia, allergic dermatitis, agranulocytosis, methaemoglobinemia, and dapsone hypersensitivity syndrome (DHS). DHS typically presents with fever, skin eruptions, Jaundice, and hepatomegaly (organ involvement). We present a case of 35-year-old female attended to Government General Hospital with complaints of fever, skin rashes, and yellowish discoloration of the eyes. She had past medication history of dapsone taken for paucibacillary leprosy for 4 weeks. Her symptoms appeared after a month and become intolerable to dapsone. Laboratory investigations revealed hepatomegaly, anemic with jaundice. Based on dermatological examination, her diagnosis was confirmed as DHS. The drug was stopped and the patient was treated with drugs for the symptomatic cure. She was recovered from her condition and the multibacillary leprosy multidrug treatment regimen was continued without dapsone

Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial

Background Most people with stroke in India have no access to organised rehabilitation services. The effectiveness of training family members to provide stroke rehabilitation is uncertain. Our primary objective was to determine whether family-led stroke rehabilitation, initiated in hospital and continued at home, would be superior to usual care in a low-resource setting. Methods The Family-led Rehabilitation after Stroke in India (ATTEND) trial was a prospectively randomised open trial with blinded endpoint done across 14 hospitals in India. Patients aged 18 years or older who had had a stroke within the past month, had residual disability and reasonable expectation of survival, and who had an informal family-nominated caregiver were randomly assigned to intervention or usual care by site coordinators using a secure web-based system with minimisation by site and stroke severity. The family members of participants in the intervention group received additional structured rehabilitation training—including information provision, joint goal setting, carer training, and task-specific training—that was started in hospital and continued at home for up to 2 months. The primary outcome was death or dependency at 6 months, defined by scores 3–6 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]) as assessed by masked observers. Analyses were by intention to treat. This trial is registered with Clinical Trials Registry-India (CTRI/2013/04/003557), Australian New Zealand Clinical Trials Registry (ACTRN12613000078752), and Universal Trial Number (U1111-1138-6707). Findings Between Jan 13, 2014, and Feb 12, 2016, 1250 patients were randomly assigned to intervention (n=623) or control (n=627) groups. 33 patients were lost to follow-up (14 intervention, 19 control) and five patients withdrew (two intervention, three control). At 6 months, 285 (47%) of 607 patients in the intervention group and 287 (47%) of 605 controls were dead or dependent (odds ratio 0·98, 95% CI 0·78–1·23, p=0·87). 72 (12%) patients in the intervention group and 86 (14%) in the control group died (p=0·27), and we observed no difference in rehospitalisation (89 [14%]patients in the intervention group vs 82 [13%] in the control group; p=0·56). We also found no difference in total non-fatal events (112 events in 82 [13%] intervention patients vs 110 events in 79 [13%] control patients; p=0·80). Interpretation Although task shifting is an attractive solution for health-care sustainability, our results do not support investment in new stroke rehabilitation services that shift tasks to family caregivers, unless new evidence emerges. A future avenue of research should be to investigate the effects of task shifting to health-care assistants or team-based community care

A facile strategy for the synthesis of highly substituted imidazole using tetrabutyl ammoniumbromide as catalyst

A simple and facile strategy for the synthesis of highly substituted imidazoles has been developed by multi-component condensation of 1,2-diketone, aldehyde, amine, and ammonium acetate in presence of tetrabutyl ammonium bromide as catalystCochin University Of Science And TechnologyRes Chem Intermed (2012) 38:359–365 DOI 10.1007/s11164-011-0352-

Castor Grey mold -Mobile Application

Not AvailableThe article describes about the Mobile app on Castor gray mold disease. It gives comprehensive details about the disease, control measures, other diseases and pests of castor and Expert system for identifying the risk of castor gray mold disease based on user inputsNot Availabl

Performance of hybrid glass/steel fibre self-compacting concrete beams under static flexural loading

In this paper, it is proposed to study the static flexural performance of hybrid (glass and steel) fiber reinforced M30 grade self-compacting concrete (SCC) beams made with glass fiber reinforcement polymer (GFRP) re-bars. Nan Su mix design approach is adopted to develop the M30 grade plain SCC (PSCC) mixes. Glass fibre SCC (GFRSCC), steel fibre SCC (GFRSCC) and hybrid fibre SCC (HFRSCC) mixes are prepared using the optimum dosages of glass (0.05%) and steel fibres (1%) by volume fraction. HFRSCC reinforced beams of size 1200 *200*150 mm will be casted with steel and GFRB rebars and tested to study the flexural properties such as ultimate flexural strength, load at first crack, deflection at the center, crack width and crack patterns. For the above fibred beams, load-deflection relations will be established. The HFRSCC beam made with GFRP rebars have the load carrying capacity 37.03% more than HFRSCC beam made with steel rebars. The deflection for the HFRSCC beam made with GFRP rebars is 61.52% more than beam made with steel rebar HFRSCC beam made with GFRP rebars increases the load at first crack, ultimate flexural strength, and deflection at the centre at failure and the crack width for same HFRSCC beam made with steel rebar