A Cross-Linguistic Preference For Torso Stability In The Lexicon: Evidence From 24 Sign Languages

When the arms move in certain ways, they can cause the torso to twist or rock. Such extraneous torso movement is undesirable, especially during sign language communication, when torso position may carry linguistic significance, so we expend effort to resist it when it is not intended. This so-called “reactive effort” has only recently been identified by Sanders and Napoli (2016), but their preliminary work on three genetically unrelated languages suggests that the effects of reactive effort can be observed cross-linguistically by examination of sign language lexicons. In particular, the frequency of different kinds of manual movements in the lexicon correlates with the amount of reactive effort needed to resist movement of the torso. Following this line of research, we present evidence from 24 sign languages confirming that there is a cross-linguistic preference for minimizing the reactive effort needed to keep the torso stable

On The Linguistic Effects Of Articulatory Ease, With A Focus On Sign Languages

Spoken language has a well-known drive for ease of articulation, which Kirchner (1998, 2004) analyzes as reduction of the total magnitude of all biomechanical forces involved. We extend Kirchner\u27s insights from vocal articulation to manual articulation, with a focus on joint usage, and we discuss ways that articulatory ease might be realized in sign languages. In particular, moving more joints and/or joints more proximal to the torso results in greater mass being moved, and thus more articulatory force being expended, than moving fewer joints or moving more distal joints. We predict that in casual conversation, where articulatory ease is prized, moving fewer joints should be favored over moving more, and moving distal joints should be favored over moving proximal joints. We report on the results of our study of the casual signing of fluent signers of American Sign Language, which confirm our predictions: in comparison to citation forms of signs, the casual variants produced by the signers in our experiment exhibit an overall decrease in average joint usage, as well as a general preference for more distal articulation than is used in citation form. We conclude that all language, regardless of modality, is shaped by a fundamental drive for ease of articulation. Our work advances a cross-modality approach for considering ease of articulation, develops a potentially important vocabulary for describing variations in signs, and demonstrates that American Sign Language exhibits variation that can be accounted for in terms of ease of articulation. We further suggest that the linguistic drive for ease of articulation is part of a broader tendency for the human body to reduce biomechanical effort in all physical activities

Cutting the Residential Apronstrings of Voting Minors

The possibility of an infusion of youthful inspiration into our democratic system became a legal reality on June 30, 1971, when the traditional voting age was lowered to eighteen. Congress had previously lowered the voting age for both state and national elections through the Voting Rights Act Amendments of 1970. However, the United States Supreme Court in Oregon v. Mitchell, upheld the lowering of the voting age in presidential and congressional elections but ruled the change unconstitutional as it applied to state and local elections. In an effort to enfranchise eighteen to twenty year olds for all elections, the twenty-sixth amendment was passed. As a result, the franchise was extended to eleven million young people. The decision by the California Supreme court in Jolicoeur v. Mihaly promotes the fullest possible extension of the franchise pursuant to the twenty-sixth amendment. Justice Peters, speaking for the majority of the court, followed constitutional precedent when he ruled against discrimination on account of minority which impinged the fundamental right to vote

Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles

Short interfering RNA (siRNA) attracts much attention for the treatment of various diseases. However, its delivery, especially via systemic routes, remains a challenge. Indeed, naked siRNAs are rapidly degraded, while complexed siRNAs massively aggregate in the blood or are captured by macrophages. Although this can be circumvented by PEGylation, we found that PEGylation had a strong negative effect on the gene silencing efficiency of siRNA-liposome complexes (siPlexes). Recently, ultrasound combined with microbubbles has been used to deliver naked siRNA but the gene silencing efficiency is rather low and very high amounts of siRNA are required. To overcome the negative effects of PEGylation and to enhance the efficiency of ultrasound assisted siRNA delivery, we coupled PEGylated siPlexes (PEG-siPlexes) to microbubbles. Ultrasound radiation of these microbubbles resulted in massive release of unaltered PEG-siPlexes. Interestingly, PEG-siPlexes loaded on microbubbles were able to enter cells after exposure to ultrasound, in contrast to free PEG-siPlexes, which were not able to enter cells rapidly. Furthermore, these PEG-siPlex loaded microbubbles induced, in the presence of ultrasound, much higher gene silencing than free PEG-siPlexes. Additionally, the PEG-siPlex loaded microbubbles only silenced the expression of genes in the presence of ultrasound, which allows space and time controlled gene silencing

Predicting the peak growth velocity in the individual child: validation of a new growth model

Predicting the peak growth velocity in an individual patient with adolescent idiopathic scoliosis is essential or determining the prognosis of the disorder and timing of the (surgical) treatment. Until the present time, no accurate method has been found to predict the timing and magnitude of the pubertal growth spurt in the individual child. A mathematical model was developed in which the partial individual growth velocity curve was linked to the generic growth velocity curve. The generic curve was shifted and stretched or shrunk, both along the age axis and the height velocity axis. The individual age and magnitude of the PGV were obtained from the new predicted complete growth velocity curve. Predictions were made using 2, 1.5, 1 and 0.5 years of the available longitudinal data of the individual child, starting at different ages. The predicted values of 210 boys and 162 girls were compared to the child’s own original values of the PGV. The individual differences were compared to differences obtained when using the generic growth velocity curve as a standard. Using 2 years of data as input for the model, all predictions of the age of the PGV in boys and girls were significantly better in comparison to using the generic values. Using only 0.5 years of data as input, the predictions with a starting age from 13 to 15.5 years in boys and from 9.5 to 14.5 years in girls were significantly better. Similar results were found for the predictions of the magnitude of the PGV. This model showed highly accurate results in predicting the individual age and magnitude of the PGV, which can be used in the treatment of patients with adolescent idiopathic scoliosis