Author Correction: The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data

Correction to: npj Parkinson’s Disease https://doi.org/10.1038/s41531-023-00472-6, published online 04 March 2023// In this article the affiliation details for Alastair J Noyce, Jonggeol Jeff Kim, Isabelle Francesca Foote, Sumit Dey were incorrectly given as ‘Department of Genetics and Genomic Sciences and Mindich Child Health and Development Institute, Icahn School of Medicine at Mount, Hess Center for Science and Medicine, New York, NY 10029, USA,’ but should have been ‘Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK’.// The affiliation details for Prabhjyot Saini were incorrectly given as ‘Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK’ but should have been ‘The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada’. The original article has been corrected

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data

Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data

Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.This project was supported by the Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Against Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research (https://gp2.org).Open Access funding provided by the National Institutes of Health (NIH).This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging (NIA), National Institutes of Health, Department of Health and Human Services; project numbers ZO1 AG000535 and ZO1 AG000949, as well as the National Institute of Neurological Disorders and StrokePeer reviewe

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Long-acting contraceptive agents: Norethisterone esters of monoalkenyl and monoalkynyl acids

9 pages, 1 table, 1 scheme.-- Available online 10 January 2003.The synthesis of nine new esters of norethisterone (17α-ethynyl-17β-hydroxyestr-4-en-3-one) is described, with the esterifying acids bearing an acetylenic or olefinic function in a chain of eight or nine carbon atoms, for evaluation as long-acting contraceptive agents.We thank the World Health Organization for financial support of this work

Perfil profesional de competencias del psicólogo sanmarquino

Taking as reference the project Tuning, research inquires about the recognition of skills generic psychologist from his identification done by students for a fifth year of the period of intership or pre-professional practice and graduates, presenting the outcome of the five powers elected overwhelmingly, establishing their differentiation and relevance.Tomando como referencia el proyecto Tuning, la investigación indaga acerca del reconocimiento de las competencias genéricas del psicólogo a partir de su identificación realizada por los estudiantes de quinto año, dle periodo de internado o práctica preprofesional y egresados, presentando los resultados de las cinco competencias mayoritariamente elegidas, estableciendo su diferenciación e importancia

Esquemas de pensamiento de autodiálogo positivo y negativo y estilos de aprendizaje en estudiantes universitarios

The research is descriptive and comparative aims to disseminate the results of psychological research on mindsets of self-talk, positive and negative, and learning styles of students in San Marcos belonging to each of the five academic field organizing vocational training: Health Sciences, Basic Sciences, Engineering, Business and Humanities. For purposes of the study has used two instruments: (1) self-talk Inventory (Calvete, Esteve, Landin), comprising two subscales: positive and negative¸ both with the technical specifications in order to draw conclusions valid and reliable, so we the original statistics, alpha coefficients of 0.89 for negative self-talk scales and 0.86, 0.79 and 0.87 for the subscales of thoughts related to anxiety, depression and anger, respectively. On the other hand, the alpha coefficients were 0.82 for positive self-Scale and 0.72, 0.76 and 0.55 for the subscales of minimization, positive affect and coping self-talk, respectively, (2) Honey-Alonso Questionnaire Learning Styles (CHAEA) investigating four learning styles: active, reflective, theoretical and pragmatic, with consequent acceptance criteria, 0.84 (theoretical), 0.82 (reflective), 0.78 (pragmatic) and 0.74 (active).La investigación es de carácter descriptivo comparativo y tiene como objetivo dar a conocer los resultados de una investigación psicológica sobre los esquemas de pensamiento de autodiálogo, positivo y negativo y estilos de aprendizaje de los estudiantes de San Marcos pertenecientes a cada una de las cinco áreas académicas que organizan la formación profesional: Ciencias de la Salud, Ciencias Básicas, Ingenierías, Ciencias Empresariales y Humanidades. Para los efectos del estudio se ha empleado dos instrumentos: (1) Inventario de Autodiálogo (Calvete, Estevés, Landin), que comprende dos subescalas: positivo y negativo, ambas con las especificaciones técnicas para poder inferir resultados válidos y confiables; así tenemos los estadísticos originales, los coeficientes alpha del 0.89 para las escalas de autodiálogo negativo y 0.86, 0.79 y 0.87 para las subescalas de pensamientos relacionados con la ansiedad, depresión e ira, respectivamente. De otro lado, los coeficientes alpha fueron 0.82 para la Escala de autodiálogo positivo y 0.72, 0.76 y 0.55 para las subescalas de minimización, afecto positivo y autoinstrucciones de afrontamiento respectivamente; (2) Cuestionario Honey-Alonso de Estilos de Aprendizaje (CHAEA) que investiga cuatro estilos de aprendizaje: activo, reflexivo, teórico y pragmático, con los consiguientes criterios de validez, 0.84 (teórico), 0.82 (reflexivo), 0.78 (pragmático) y 0.74 (activo)

Representaciones sociales sobre el psicólogo en profesores de la educación básica pública y privada de lima (costa) y provincias (sierra y selva)

Is a descriptive research using a qualitative and ethnographic study examines the social representations of the psychologist in the teachers of basic education, especially secondary schools, working in public and private institutions of Peru The variety of responses from teachers set a range of images that characterize the psychologist as a professional specializing in mental health, its sensitivity in differentiating was working with the community, with certain trends in Lima (Costa) and the Sierra and Selva. Social representation of teachers from the coast tends to recognize the psychologist with the following characteristics: on the coast: Research Specialist, Psychotherapist and Counselor in the mountains: Promoting awareness and Welfare, and the jungle: Promoter of Happiness Image and Ethics.Constituye una investigación descriptiva de carácter cualitativa y empleando el método etnográfico estudia las representaciones sociales del psicólogo en los profesores de la educación básica, específicamente de secundaria, que trabajan en instituciones públicas y privadas del Perú La variedad de respuestas de los profesores configuran un abanico de imágenes del psicólogo al que caracterizan como un profesional especializado en la salud mental, diferenciando en su sensibilidad hacía el trabajo con la colectividad, con ciertas tendencias en Lima (Costa) y en la Sierra y Selva. Las representaciones sociales de los profesores de la costa tienden a reconocer en el psicólogo con las siguientes características: en la costa: Investigador Especializado; Psicoterapeuta y Consejero; en la sierra: Concientizador y Promotor del Bienestar; y en la selva: Promotor de la Felicidad e Imagen Ética

Modelos mentales de la calidad universitaria en estudiantes sanmarquinos

Investigation takes as reference the contributions from Cognitiva Psychologist on mental models, in the proposals of Johnson-Laird (1996), Moreira (1997) and Vergnaud (1996), as well as construction cognitive of the concept of university quality in its different dimensions and proposals. The investigation is exploratory, descriptive and comparative. The objectives of investigation are the following ones: 1. Identify and to characterize the mental models developed by the university students, 2. Determine the characteristics and attributes and to compare them in the five academics areas who organize the studies in Universidad Nacional Mayor de San Marcos. We have developed the analysis method of content, based in connotative meanings of quality, by selecting concepts accepted in technical approaches and representations made by the students. It has identified eighteen parameters of quality with three levels classified in each one. The mental model is induced by the argumentales theoric constructions accepted by conceptual systems and common knowledge. The finding of investigation centralizes in the peculiarities of the mental model that have the students in each one of the implied criminals in the study, selected five parameters for the present effects of it publication. Investigacin establishes one comparacin in construccin of the mental models about the university quality in five academic areas in reference.La investigación toma como referencia los aportes de la Psicología Cognitiva sobre modelos mentales, en las propuestas de Johnson-Laird (1996), Moreira (1997) y Vergnaud (1996), así como la construcción cognitiva del concepto de calidad universitaria en sus distintas dimensiones y propuestas. Es una investigación de carácter exploratoria, descriptiva y comparativa. Los objetivos de la investigación son los siguientes: 1. Identificar y caracterizar los modelos mentales desarrollados por los estudiantes universitarios, 2. Determinar los rasgos y atributos construidos y compararlos en las cinco áreas académicas que organizan los estudios en la Universidad Nacional Mayor de San Marcos. Se empleó el método del análisis de contenido, basado en los significados connotativos de la calidad, por una selección de conceptos aceptados en los enfoques técnicos de la misma y de otro lado las representaciones realizadas por los estudiantes. Se identifica 18 parámetros de la calidad con tres niveles clasificados en cada uno. El modelo mental es inducido por las construcciones teóricas argumentales aceptadas por sistemas conceptuales y conocimientos comunes. El hallazgo de la investigación se centraliza en las peculiaridades del modelo mental que tienen los estudiantes en cada una de las áreas implicadas en el estudio, seleccionado 5 parámetros para los efectos de la presente publicación. La investigación establece una comparación en la construcción de los modelos mentales acerca de la calidad universitaria en las cinco áreas académicas en referencia

Long-acting contraceptive agents: norethisterone esters of arylcarboxylic acids

12 pages, 1 table, 1 scheme.-- PMID: 6658878 [PubMed].The synthesis of esters of norethisterone (17α-ethynyl-17β-hydroxy-estr-4-en-3-one) with acids containing a benzene ring is described, two methods of esterification being compared in terms of yield and convenience. The activities of these esters as long-acting contraceptive agents have been evaluated.This work, involving synthetic chemists from four countries, received financial grants from the World Health Organization, under the WHO Special Programme of Research, Development and Research Training in Human Reproduction