A novel mechanism for binding of galactose-terminated glycans by the C-type carbohydrate recognition domain in blood dendritic cell antigen 2

Blood dendritic cell antigen 2 (BDCA-2; also designated CLEC4C or CD303) is uniquely expressed on plasmacytoid dendritic cells. Stimulation of BDCA-2 with antibodies leads to an anti-inflammatory response in these cells, but the natural ligands for the receptor are not known. The C-type carbohydrate recognition domain in the extracellular portion of BDCA-2 contains a signature motif typical of C-type animal lectins that bind mannose, glucose, or GlcNAc, yet it has been reported that BDCA-2 binds selectively to galactose-terminated, biantennary N-linked glycans. A combination of glycan array analysis and binding competition studies with monosaccharides and natural and synthetic oligosaccharides have been used to define the binding epitope for BDCA-2 as the trisaccharide Galβ1–3/4GlcNAcβ1–2Man. X-ray crystallography and mutagenesis studies show that mannose is ligated to the conserved Ca2+ in the primary binding site that is characteristic of C-type carbohydrate recognition domains, and the GlcNAc and galactose residues make additional interactions in a wide, shallow groove adjacent to the primary binding site. As predicted from these studies, BDCA-2 binds to IgG, which bears galactose-terminated glycans that are not commonly found attached to other serum glycoproteins. Thus, BDCA-2 has the potential to serve as a previously unrecognized immunoglobulin Fc receptor

Aplikasi Pengenalan Nama Surah pada Juz ke 30 Kitab Suci Al-Qur'an Menggunakan Speech Recognition

Al-Qur'an is a scripture which contains the saying of Allah Subhanahu Wa Ta'aala and was revealed to Prophet Muhammad. The 30th juz is the juz that exists in the Al-Qur'an. When studying how to read Al-Qur'an well, the first thing that is learned is reading and memorizing surahs in the 30th juz. Nevertheless, there is a problem in remembering or knowing the surah name and the verse which are in the 30th juz. An android application was developed in order to recognize the surah names in the 30th juz by utilizing speech recognition technology to overcome that problem. Markov Model (Markov Chain) algorithm was implemented in this application. This algorithm will process user's speech and compute probability of the surah name that was spoken. Speech detection testing gave result that the highest accuracy of application in recognizing the speeches was in the environment without noise with the accuracy of 100% in the most ideal distance is 50 cm for male and for female user. Based on the blackbox testing result, all functionalities of the application have functionated well. Control flow testing gave result that the value is 7 which indicates that the code is simple and well written. 87,74% respondents answered, by filling up the questionnaires, that the application is useful in order to make user knows better about the surah names in the 30th juz

Effects of Policies Designed to Keep Firearms from High-Risk Individuals

This article summarizes and critiques available evidence from studies published between 1999 and August 2014 on the effects of policies designed to keep firearms from high-risk individuals in the United States. Some prohibitions for high-risk individuals (e.g., those under domestic violence restraining orders, violent misdemeanants) and procedures for checking for more types of prohibiting conditions are associated with lower rates of violence. Certain laws intended to prevent prohibited persons from accessing firearms -- rigorous permit-to-purchase, comprehensive background checks, strong regulation and oversight of gun dealers, and requiring gun owners to promptly report lost or stolen firearms -- are negatively associated with the diversion of guns to criminals. Future research is needed to examine whether these laws curtail nonlethal gun violence and whether the effects of expanding prohibiting conditions for firearm possession are modified by the presence of policies to prevent diversion

Efektivitas Pelaksanaan Perda Pengelolaan Zakat di Kota Mojokerto dan Kabupaten Sidoarjo

Abstract: Currently, local regulations on zakat (Islamic obligatory charity) management has been set up in many regions in Indonesia. InMojokerto and Sidoarjo regency, such local regulations are expected to be effective for improving the welfare of the society.This local zakat management that has the role to collect and distribute zakat is called BAZ (BadanAmil Zakat). It seems that the zakat management in Mojokerto and Sidoarjo is more effective under the present of such a local regulation. It can be seen from the increase number of the charity payers, the increase of BAZ’s charity programs, and the operation costs charged to APBD (Regional Government Budget).If it is analyzed by the effectiveness legal theory, it can be concluded that the observance of a rule of law (the perda or local regulation on the charity management) in Mojokerto and Sidoarjo regency is a kind of the internalizational obedience. It is because such observance of a rule of law is in accordance with the intrinsic values adopted. In addition, such local regulations are obeyed because giving charity is one of the fundamental Islamic teachings. The values embodied in charity in Islam have a very clear purpose, benefit, and punishment in the world and in the hereafter. These Islamic values contribute dearly to the success of the application of this local regulation on the charity management. Keywords: Charity management, local regulation, effectiveness, and BAZ.   Abstrak: Saat ini zakat telah diatur dalam bentuk suatu Peraturan Daerah seperti Peraturan Daerah tentang Pengelolaan Zakat di Kota Mojokerto dan Kabupaten Sidoarjo. Dengan adanya Perda tersebut, diharapkan efektif untuk meningkatkan kesejahteraan masyarakat khususnya di Kota Mojokerto dan Kabupaten Sidoarjo. Perkembangan pengelolaan zakat pada BAZ di Kota Mojokerto dan Kabupaten Sidoarjo dengan adanya Perda tentang pengelolaan zakat menjadi lebih efektif. Hal itu bisa dilihat dari bertambahnya jumlah mudhakki, peningkatan perolehan dana zakat serta biaya operasional BAZ yang dibebankan kepada APBD. Apabila dianalisis dengan teori efektivitas hukum, maka bisa diambil kesimpulan bahwa ketaatan terhadap suatu aturan hukum (dalam hal ini adalah Perda tentang Pengelolaan zakat) di Kota Mojokerto dan Kabupaten Sidoarjo bersifat ketaatan internalization, yakni suatu peraturan ditaati karena merasa aturan itu sesuai dengan nilai-nilai intrinsik yang dianut. Perda tentang pengelolaan zakat ditaati karena menunaikan zakat merupakan ajaran Islam. Nilai-nilai yang terkandung dalam ajaran Islam mengenai zakat sangat jelas baik tujuan, manfaat serta sanksi baik di dunia maupun di akhirat. Nilai-nilai inilah yang menjadi dasar dalam menaati Perda tentang Pengelolaan Zakat yang sesuai dengan ajaran Islam. &nbsp

STUDI KELEBIHAN MUATAN KENDARAAN ( OVERLOAD ) TERHADAP PENURUNAN UMUR RENCANA JALAN PADA RUAS JALAN SAMARINDA BALIKPAPAN

Safry, Studi kelebihan muatan kendaraan ( overload ) terhadap penurunan umur rencana jalan pada ruas jalan Samarinda Balikpapan, di bawah bimbingan Rosa Agustaniah, ST., M.T dan Suratmi, ST., M.T.Di jalan Samarinda Balikpapan banyak ditemuakan kendaraan yang bermuatan lebih, hal itu akan menyebabkan kerusakan dini pada perkerasan jalan dan akan mengurangi umur rencana perkerasan jalan. Berdasarkan hal itu perlu dilakukan studi pengaruh muatan lebih terhadap umur rencana perkerasan jalan pada ruas jalan Samarinda Balikpapan. Untuk mengetahui seberapa besar penurunan umur rencana dan sisa umur rencana jalan dilakukan analisa dan perhitungan data timbang muatan sumbu terberat (MTS) di lapangan, mengetahui sumbu dan distribusi beban kendaraan, menganalisa perhitungan lintas ekivalen rencana (LER) muatan normal, lalu lintas harian rata-rata awal umur rencana (LHRo), lalu lintas harian rata-rata ahir umur rencana (LHRn), lintas ekivalen permulaan (LEP)umur rencana, lintas ekivalen akhir umur rencana (LEAn), lintas ekivalen tengah (LET), lintas ekivalen rencana (LER), perhitungan lintas ekivalen rencana (LER) akibat muatan lebih di lapangan, menghitung LHR akhir (LHRn).Dari analisa dan perhitungan penurunan umur rencana perkerasan jalan akibat muatan lebih. tersebut di dapat penurunan umur rencana jalan selama 8,6 tahun dari umur rencana 10 tahun, dengan demikian sisa umur rencana menjadi 1,3 tahun

STUDI KELEBIHAN MUATAN KENDARAAN ( OVERLOAD ) TERHADAP PENURUNAN UMUR RENCANA JALAN PADA RUAS JALAN SAMARINDA BALIKPAPAN

Safry, Studi kelebihan muatan kendaraan ( overload ) terhadap penurunan umur rencana jalan pada ruas jalan Samarinda Balikpapan, di bawah bimbingan Rosa Agustaniah, ST., M.T dan Suratmi, ST., M.T.Di jalan Samarinda Balikpapan banyak ditemuakan kendaraan yang bermuatan lebih, hal itu akan menyebabkan kerusakan dini pada perkerasan jalan dan akan mengurangi umur rencana perkerasan jalan. Berdasarkan hal itu perlu dilakukan studi pengaruh muatan lebih terhadap umur rencana perkerasan jalan pada ruas jalan Samarinda Balikpapan. Untuk mengetahui seberapa besar penurunan umur rencana dan sisa umur rencana jalan dilakukan analisa dan perhitungan data timbang muatan sumbu terberat (MTS) di lapangan, mengetahui sumbu dan distribusi beban kendaraan, menganalisa perhitungan lintas ekivalen rencana (LER) muatan normal, lalu lintas harian rata-rata awal umur rencana (LHRo), lalu lintas harian rata-rata ahir umur rencana (LHRn), lintas ekivalen permulaan (LEP)umur rencana, lintas ekivalen akhir umur rencana (LEAn), lintas ekivalen tengah (LET), lintas ekivalen rencana (LER), perhitungan lintas ekivalen rencana (LER) akibat muatan lebih di lapangan, menghitung LHR akhir (LHRn).Dari analisa dan perhitungan penurunan umur rencana perkerasan jalan akibat muatan lebih. tersebut di dapat penurunan umur rencana jalan selama 8,6 tahun dari umur rencana 10 tahun, dengan demikian sisa umur rencana menjadi 1,3 tahun

A method for the analysis of lot- house relations in Ottoman housing patter

Thesis (Doctoral)--İzmir Institute of Technology, Architecture, İzmir, 2011Includes bibliographical references (leaves: 257-264)Text in English; Abstract: Turkish and Englishxviii, 354 leavesDefining the lot - house relations in the Ottoman housing pattern is significant for determining the authentic settlement characteristics of the pattern. In this context, this study, based on a morphological analysis method, claims the necessity of analyzing the pattern in terms of house-lot related parameters. Geographic Information System (GIS) software has been used for the visualization of analysis results. The aim is to create a set of rules between the house and lot. The inferences to be obtained as a result of this study can be used as a design guide in the field, in which method is to be applied for creating a conservation plan for a project. The study area selected was Edirne Kaleiçi Region. The method was created through a three-phase system. The variables were specified in the first phase; and then analyses that would display the structural relations were determined. The implementation and evaluation phase was the third phase of the method. As a conclusion of examining the lot - house relations within the parameters set, the thesis has identified the morphological relations with respect to the main plan types, sub plan types and lots. On the condition that this method is applied in other cities, it would be possible to comment more on the lot - house relations for the Ottoman house pattern