Subcentimeter depth resolution using a single-photon counting time-of-flight laser ranging system at 1550 nm wavelength

We demonstrate subcentimeter depth profiling at a stand off distance of 330m using a time-of-flight approach based on time-correlated single-photon counting. For the first time to our knowledge, the photon-counting time-of-flight technique was demonstrated at a wavelength of 1550nm using a superconducting nanowire single-photon detector. The performance achieved suggests that a system using superconducting detectors has the potential for low-light-level and eye-safe operation. The system’s instrumental response was 70ps full width at half-maximum, which meant that 1cm surface-to-surface resolution could be achieved by locating the centroids of each return signal. A depth resolution of 4mm was achieved by employing an optimized signal-processing algorithm based on a reversible jump Markov chain Monte Carlo method

A Standard Input Format for Multiperiod Stochastic Linear Programs

Data conventions for the automatic input of multiperiod stochastic linear programs are described. The input format is based on the MPSX standard and is designed to promote the efficient conversion of originally deterministic problems by introducing stochastic variants in separate files. A flexible "header" syntax generates a useful variety of stochastic dependencies. An extension using the NETGEN format is proposed for stochastic network programs

Spatiotemporal dynamics and modelling support the case for area-wide management of citrus greasy spot in a Brazilian smallholder farming region

Citrus greasy spot (CGS), caused by Zasmidium citri, induces premature defoliation and yield loss in Citrus spp. The epidemiology of CGS is well understood in high humidity areas, but remains unaddressed in Brazil, despite differing climatic conditions and disease management practices. The spatiotemporal dynamics of CGS was characterized in the Recôncavo of Bahia (Brazil) at four hierarchical levels (quadrant, plant, grove and region). A survey conducted in 19 municipalities found the disease to be present throughout the region with an incidence of 100% in groves and plants, and higher than 70% on leaves. Index of dispersion (D) values suggest the spatial pattern of symptomatic units lies between random and regular. This was confirmed by the parameters of the binary power law for plants and their quadrants (log(A)<0 and b<1). No consistent differences were observed in the disease incidence at different plant heights. We introduce a compartmental model synthesizing CGS epidemiology. The collected data allow such a model to be parameterised, albeit with some ambiguity over the proportion of new infections that result from inoculum produced within the grove vs. external sources of infection. By extending the model to include two populations of growers – those who control and those who do not – coupled by the airborne inoculum, we investigate likely performance of cultural controls accessible to citrus growers in Northeastern Brazil. The results show that control via removal of fallen leaves can be very effective. However, successful control is likely to require area-wide strategies, in which a large proportion of growers actively manage disease

Meditation-induced bliss viewed as release from conditioned neural (thought) patterns that block reward signals in the brain pleasure center

The nucleus accumbens orchestrates processes related to reward and pleasure, including the addictive consequences of repeated reward (e.g., drug addiction and compulsive gambling) and the accompanying feelings of craving and anhedonia. The neurotransmitters dopamine and endogenous opiates play interactive roles in these processes. They are released by natural rewards (i.e., food, water, sex, money, play, etc.) and are released or mimicked by drugs of abuse. Repeated drug use induces conditioned down-regulation of these neurotransmitters, thus causing painful suppression of everyday pleasure. As with many spiritual traditions, Buddhism provides strong advice against the pursuit of worldly pleasures to attain the ‘‘good life.’’ In contrast, many forms of meditation give rise to an immense and abiding joy. Most of these practices involve ‘‘stilling the mind,’’ whereby all content-laden thought (e.g., fantasies, daydreams, plans) ceases, and the mind enters a state of openness, formlessness, clarity, and bliss. This can be explained by the Buddhist suggestion that almost all of our everyday thoughts are a form of addiction. It follows that if we turn off this internal ‘‘gossip of ego,’’ we will find relief from the biochemical dopamine/opiate down-regulation, which is, perhaps, the perpetual concomitant of our daily rumination

The health and educational costs of preterm birth to 18 years of age in Australia

Background: Preterm birth is the greatest cause of death up to five years of age and an im-portant contributor to lifelong disability. There is increasing evidence that a meaningful pro-portion of early births may be prevented, but widespread introduction of effective preventive strategies will require financial support.Aims: This study estimated the economic cost to the Australian government of preterm birth, up to 18 years of age.Materials and Methods: A decision-analytic model was developed to estimate the costs of preterm birth in Australia for a hypothetical cohort of 314 814 children, the number of live births in 2016. Costs to Australia’s eight jurisdictions included medical expenditures and ad-ditional costs to educational services.Results: The total cost of preterm birth to the Australian government associated with the an-nual cohort was estimated at $1.413 billion (95% CI 1047-1781). Two-thirds of the costs were borne by healthcare services during the newborn period and one-quarter of the costs by educational services providing special assistance. For each child, the costs were highest for those born at the earliest survivable gestational age, but the larger numbers of children born at later gestational ages contributed heavily to the overall economic burden.Conclusion: Preterm birth leaves many people with lifelong disabilities and generates a sig-nificant economic burden to society. The costs extend beyond those to the healthcare system and include additional educational needs. Assessments of economic costs should inform eco-nomic evaluations of interventions aimed at the prevention or treatment of preterm birth.John P. Newnham, Chris Schilling, Stavros Petrou, Jonathan M Morris, Euan M. Wallace, Kiarna Brown ... et al

The Multiwavelength Approach to Unidentified Gamma-Ray Sources

As the highest-energy photons, gamma rays have an inherent interest to astrophysicists and particle physicists studying high-energy, nonthermal processes. Gamma-ray telescopes complement those at other wavelengths, especially radio, optical, and X-ray, providing the broad, mutiwavelength coverage that has become such a powerful aspect of modern astrophysics. Multiwavelength techniques of various types have been developed to help identify and explore unidentified gamma-ray sources. This overview summarizes the ideas behind several of these methods.Comment: Proceedings of the Conference "The Multiwavelength Approach to Unidentified Sources", to appear in the journal Astrophysics and Space Scienc

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments that prevent relapse have not been developed. Drug addiction is now considered a brain disease, because the abuse of drugs affects several brain functions. Neurological impairments observed in drug addicts may reflect drug-induced neuronal dysfunction and neurotoxicity. The drugs of abuse directly or indirectly affect neurotransmitter systems, particularly dopaminergic and glutamatergic neurons. This review explores the literature reporting cellular and molecular alterations reflecting the cytotoxicity induced by amphetamines, cocaine and opiates in neuronal systems. The neurotoxic effects of drugs of abuse are often associated with oxidative stress, mitochondrial dysfunction, apoptosis and inhibition of neurogenesis, among other mechanisms. Understanding the mechanisms that underlie brain dysfunction observed in drug-addicted individuals may contribute to improve the treatment of drug addiction, which may have social and economic consequences.http://www.sciencedirect.com/science/article/B6SYS-4S50K2J-1/1/7d11c902193bfa3f1f57030572f7034