86 research outputs found

    3D Flapping Trajectory of a Micro-Air-Vehicle and its Application to Unsteady Flow Simulation

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    [[abstract]]A three-dimensional (3D) trajectory detection framework using two high-speed cameras for the flapping flexible wing of a micro-air-vehicle (MAV) is presented. This MAV, which is called the “Golden Snitch”, has a successful flight record of 8 minutes. We embed the flexible wingskin with a nine light emitting diode (LED) array as the light enhancing marker and capsulate it with parylene (poly-para-xylylene) as the protection layer. We confirm an oblique figure of eight trajectory of this MAV’s wing with time-varying coordinate data. The corresponding aerofoil of the main wings’ profiles was subjected to the time-varying coordinate data, yielding a resolution of a 1/70 wing beating cycle of 15Hz flapping. The trajectory information is first demonstrated as the moving boundaries of an unsteady flow simulation around a flapping flexible wing.[[notice]]補正完畢[[journaltype]]國外[[incitationindex]]SCI[[ispeerreviewed]]Y[[booktype]]電子版[[booktype]]紙本[[countrycodes]]HR

    Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome

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    AbstractDravet syndrome is a devastating genetic brain disorder caused by heterozygous loss-of-function mutation in the voltage-gated sodium channel gene SCN1A. There are currently no treatments, but the upregulation of SCN1A healthy allele represents an appealing therapeutic strategy. In this study we identified a novel, evolutionary conserved mechanism controlling the expression of SCN1A that is mediated by an antisense non-coding RNA (SCN1ANAT). Using oligonucleotide-based compounds (AntagoNATs) targeting SCN1ANAT we were able to induce specific upregulation of SCN1A both in vitro and in vivo, in the brain of Dravet knock-in mouse model and a non-human primate. AntagoNAT-mediated upregulation of Scn1a in postnatal Dravet mice led to significant improvements in seizure phenotype and excitability of hippocampal interneurons. These results further elucidate the pathophysiology of Dravet syndrome and outline a possible new approach for the treatment of this and other genetic disorders with similar etiology

    Mechanical properties, microstructure and crystallographic texture of magnesium AZ91-D alloy welded by Friction Stir Welding (FSW)

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    The objective of the study was to characterize the properties of a magnesium alloy welded by friction stir welding (FSW). The results led to a better understanding of the relationship between this process and the microstructure and anisotropic properties of alloy materials. Welding principally leads to a large reduction in grain size in welded zones due to the phenomenon of dynamic recrystallization. The most remarkable observation was that crystallographic textures appeared from a base metal without texture in two zones: the thermo-mechanically affected and stir welded zones. The latter zone has the peculiarity of possessing a marked texture with two components on the basal plane and the pyramidal plane. These characteristics disappeared in the TMAZ, which had only one component following the basal plane. These modifications have been explained by the nature of the plastic deformation in these zones, which occurs at a moderate temperature in the TMAZ and high temperature in the SWZ

    Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

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    Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

    Quality Improvement of Netted Melon (Cucumis melo L. var. reticulatus) through Precise Nitrogen and Potassium Management in a Hydroponic System

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    The quality-oriented fruit production in well-controlled enclosed hydroponic systems has been greatly enhanced by the technology of precision agriculture. Over-fertilisation has been commonly applied to the traditional hydroponic culture of fruit crops, without considering different nutrient demands during development. Adjusting the nutrient formulations depending on crop developmental stages could enable efficient fertilisation to increase yield quality. In this study, N-reduced and K-modified nutrient solutions were applied for a two-step nutrient manipulation experiment, to improve the fruit quality (Experiment I) and optimise the fertilisation schemes (Experiment II) of hydroponic netted melon (Cucumis melo L. var. reticulatus). The N-reduced and K-modified treatments, before fruiting stage in Experiment I, obtained higher fruit quality with increased fruit weight, dry matter ratio, flesh thickness, and total soluble solids. In Experiment II, fruits cultured under treatment II-3 (applied with 100-75-100% N and 100-125-75% K during VG-PYF-FEM) had the highest overall preferences, with ‘rich’ aroma, ‘dense’ texture, and ‘perfect’ sweetness, compared to all other experimental treatments. Our study successfully improved the fertilisation schemes for a hydroponic netted melon with precise N- and K-nutrient formulations specific to different developmental stages. Our study promotes the future advancement of precise fertilisation to improve fruit quality and reduce environmental pollution from farming activities

    An OLAP Server for Sensor Networks Using Augmented Statistics Trees

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    The datacube is a conceptual data structure to support On-Line Analytical Processing (OLAP). It is essentially a series of tables organized according to attributes (called dimensions). Table rows (or cells) contain aggregated information for collections of records that satisfy value constraints for each dimension. The Statistics Tree (ST) uses a tree structure for storing the datacube in memory in order to optimize cell lookup time and handle a variety of types of cell-based queries. An Augmented ST (AST) is proposed with additional list structures within the ST. The additional lists link together the cells that comprise the tables of the datacube. An algorithm that builds table lists requires only a single traversal of the ST. Thus the AST supports both cell-level and table-level queries. Algorithms to build and update datacubes stored as ASTs are shown. A web-based wireless sensor network OLAP server based on the AST is described
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