Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage

Determination of the quantitative composition of phenotypically and morphologically different populations of resident microglia and infiltrating macrophages in spinal cord injury (SCI) of various degrees of severity could lead to much needed novel therapeutic interventions in neurotrauma. In this regard, we investigated the CD40 and TGF-β expressing populations of microglia/macrophages and their morphological states in a rat model of SCI of varying severity. We are the first to describe the annular-shaped microglia/macrophages, the morphology of which was formed due to the spatial orientation of the processes that form round or oval micro-territories, which include disintegrating myelin fibers. This type of cell morphology was found only in the injured spinal cord and mainly in the white matter. At the same time, an assessment of the number of annular-shaped microglia/macrophages and the diameter of micro-territories formed by their processes showed an elevation in these indicators as the severity of SCI increased. While we did not find significant quantitative changes in the populations of Iba1+/CD40+ and Iba1+/TGF-β+ microglia/macrophages with increased severity of SCI in the chronic period (60 dpi), we did determine changes in the expression of cytokines and mRNAs of genes-encoding microglial marker proteins, finding the greatest changes on days 7 and 14 after SCI between experimental groups with varying severity

Assessment of occupational risks of employees engaged in open-pit mining

Currently, Uzbekistan is in the process of legislation modernization, primarily in matters of labor protection and industrial safety. Modernization consists in the transition from a previously existing ineffective system focused on compensation payments to a modern system based on preventive approaches, which imply continuous improvement of work conditions. The aim of this work is to analyze the legislation in the field of labor protection management, obliging employers to proceed to occupational risks assessment and their management, as well as the assessment of occupational risks for miners, working under the influence of harmful and dangerous production factors during gold mining in the quarry, and the development of measures to reduce them. The possible reasons for the discrepancy with the stated requirements of the physical factors of the miners working environment when performing work in gold mining quarries are analyzed. It has been established that professional risks for personnel are classified as high and medium and it is necessary to carry out organizational and technical measures to minimize them

Aspects of Sustainable Development of Russian Regional Universities

Modern universities present themselves as universities implementing the goals of sustainable development. The aim of this paper is to summarize the experience of universities in the world and Russia in the field of sustainable development and to work out a comprehensive program for the development of the Irkutsk National Research Technical University to achieve the goals of preserving the planet and creating a “green campus” taking into account regional aspects associated with the uniqueness of Lake Baikal. The paper considers the experience of a number of European universities and presents the directions of the long-term development program for the Irkutsk National Research University, resulting in the development of the Baikal region. In the work, we also consider aspects of the program taking into account the uniqueness of Lake Baikal

OWN EDUCATIONAL STANDARD OF THE IRKUTSK NATIONAL RESEARCH TECHNICAL UNIVERSITY IN THE DIRECTION OF TRAINING "TECHNOSPHERE SAFETY”

The modern approaches to the training of students in the direction of "Techno sphere safety" are considered. It is shown that in order to improve the professional competence of students, it is possible to achieve using their own educational standards, based on which the use of the technology of the project method is recommended, as one of the most effective teaching method. The content of the standard and innovative teaching technologies used in IRNITU are considered. It is concluded that innovative teaching technologies make it possible to activate the work of students and prepare them for further professional activities at enterprises

Ontogenetic Characteristics of Anxiety of Gymnasts of High Sports Qualification

Aim: We have identified age-related changes in the level of anxiety in athletes involved in rhythmic gymnastics. In this article the need for a differentiated approach of psychological preparation is proved, when planning a training process in different periods of ontogenesis of gymnasts In the rhythmic gymnastics it is a necessity to make a decision on the preparation of a training course. Material and Methods. The present study involved girls engaged in rhythmic gymnastics with high sports qualification at the age of 10-15 years of age: the 1st category included 48 gymnasts, CMS-36, MS-20 (n=104). The control group is represented by girls who do not play sports (n=100). The "anxiety Scale" was used as a method of diagnosing the level of anxiety [6]. The experimental results were subjected to variations and statistical processing." Results. Clear age differences in indicators of Interpersonal anxiety gymnasts were revealed. The maximum values in both the experimental and control groups were recorded at the age of 12-13 years. Throughout puberty the sportswomen of measure of Interpersonal anxiety was higher than in the controls. The level of school anxiety in gymnasts of 10 and 12-15 years is significantly higher in girls of the control group (P<0.01<0.05). The maximum values are recorded in athletes aged 12-13 years old, outside the norm. An increase in the level of self-esteem anxiety in girls engaged in gymnastics was detected at the age of 12-15 years (P<0.05-<0.001); the maximum values of interpersonal anxiety fall on the age of 10 and 12 years (P<0.01 - <0.001). Conclusions. The age at which there is a maximum level of anxiety in gymnasts, high sports skills on all scales, falls on 12-13 years. In all age groups, female athletes have significantly higher anxiety than those in the control group. School and self-esteem anxiety have a clear age dynamic, which is significantly different from that in the control group throughout the studied age boundaries