183 research outputs found
Stable Non-Supersymmetric Supergravity Solutions from Deformations of the Maldacena-Nunez Background
We study a deformation of the type IIB Maldacena-Nunez background which
arises as the near-horizon limit of NS5 branes wrapped on a two-cycle. This
background is dual to a "little string theory" compactified on a two-sphere, a
theory which at low energies includes four-dimensional N = 1 super Yang-Mills
theory. The deformation we study corresponds to a mass term for some of the
scalar fields in this theory, and it breaks supersymmetry completely. In the
language of seven-dimensional SO(4) gauged supergravity the deformation
involves (at leading order) giving a VEV, depending only on the radial
coordinate, to a particular scalar field. We explicitly construct the
corresponding solution at leading order in the deformation, both in
seven-dimensional and in ten-dimensional supergravity, and we verify that it
completely breaks supersymmetry. Since the original background had a mass gap
and we are performing a small deformation, the deformed background is
guaranteed to be stable even though it is not supersymmetric.Comment: 1+31 pages, one figure. v2: minor clarifications, refs adde
Linear square-mass trajectories of radially and orbitally excited hadrons in holographic QCD
We consider a new approach towards constructing approximate holographic duals
of QCD from experimental hadron properties. This framework allows us to derive
a gravity dual which reproduces the empirically found linear square-mass
trajectories of universal slope for radially and orbitally excited hadrons.
Conformal symmetry breaking in the bulk is exclusively due to infrared
deformations of the anti-de Sitter metric and governed by one free mass scale
proportional to Lambda_QCD. The resulting background geometry exhibits dual
signatures of confinement and provides the first examples of holographically
generated linear trajectories in the baryon sector. The predictions for the
light hadron spectrum include new relations between trajectory slopes and
ground state masses and are in good overall agreement with experiment.Comment: 33 pages, 5 figures, updated to the extended version published in
JHEP, vector meson bulk potential and metric corrected, comments and
references added, phenomenology and conclusions unchange
The IMF in Starbursts
The history of the IMF in starburst regions is reviewed. The IMFs are no
longer believed to be top-heavy, although some superstar clusters, whether in
starburst regions or not, could be. General observations of the IMF are
discussed to put the starburst results in perspective. Observed IMF variations
seem to suggest that the IMF varies a little with environment in the sense that
denser and more massive clusters produce more massive stars, and perhaps more
brown dwarfs too, compared to intermediate mass stars.Comment: 8 pages, to be published in ``Starbursts: from 30 Doradus to Lyman
Break Galaxies,'' held at Institute of Astronomy, Cambridge University, UK,
September 6-10, 2004. Kluwer Academic Publishers, edited by Richard de Grijs
and Rosa M. Gonzalez Delgad
A cross-institutional analysis of the effects of broadening trainee professional development on research productivity
PhD-trained scientists are essential contributors to the workforce in diverse employment sectors that include academia, industry, government, and nonprofit organizations. Hence, best practices for training the future biomedical workforce are of national concern. Complementing coursework and laboratory research training, many institutions now offer professional training that enables career exploration and develops a broad set of skills critical to various career paths. The National Institutes of Health (NIH) funded academic institutions to design innovative programming to enable this professional development through a mechanism known as Broadening Experiences in Scientific Training (BEST). Programming at the NIH BEST awardee institutions included career panels, skill-building workshops, job search workshops, site visits, and internships. Because doctoral training is lengthy and requires focused attention on dissertation research, an initial concern was that students participating in additional complementary training activities might exhibit an increased time to degree or diminished research productivity. Metrics were analyzed from 10 NIH BEST awardee institutions to address this concern, using time to degree and publication records as measures of efficiency and productivity. Comparing doctoral students who participated to those who did not, results revealed that across these diverse academic institutions, there were no differences in time to degree or manuscript output. Our findings support the policy that doctoral students should participate in career and professional development opportunities that are intended to prepare them for a variety of diverse and important careers in the workforce
Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast
Cluster Density and the IMF
Observed variations in the IMF are reviewed with an emphasis on environmental
density. The remote field IMF studied in the LMC by several authors is clearly
steeper than most cluster IMFs, which have slopes close to the Salpeter value.
Local field regions of star formation, like Taurus, may have relatively steep
IMFs too. Very dense and massive clusters, like super star clusters, could have
flatter IMFs, or inner-truncated IMFs. We propose that these variations are the
result of three distinct processes during star formation that affect the mass
function in different ways depending on mass range. At solar to intermediate
stellar masses, gas processes involving thermal pressure and supersonic
turbulence determine the basic scale for stellar mass, starting with the
observed pre-stellar condensations, and they define the mass function from
several tenths to several solar masses. Brown dwarfs require extraordinarily
high pressures for fragmentation from the gas, and presumably form inside the
pre-stellar condensations during mutual collisions, secondary fragmentations,
or in disks. High mass stars form in excess of the numbers expected from pure
turbulent fragmentation as pre-stellar condensations coalesce and accrete with
an enhanced gravitational cross section. Variations in the interaction rate,
interaction strength, and accretion rate among the primary fragments formed by
turbulence lead to variations in the relative proportions of brown dwarfs,
solar to intermediate mass stars, and high mass stars.Comment: 14 pages, 3 figures, to be published in ``IMF@50: A Fest-Colloquium
in honor of Edwin E. Salpeter,'' held at Abbazia di Spineto, Siena, Italy,
May 16-20, 2004. Kluwer Academic Publishers; edited by E. Corbelli, F. Palla,
and H. Zinnecke
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes
KPTN-related disorder is an autosomal recessive disorder associated with germline variants in KPTN (previously known as kaptin), a component of the mTOR regulatory complex KICSTOR. To gain further insights into the pathogenesis of KPTN-related disorder, we analysed mouse knockout and human stem cell KPTN loss-of-function models.Kptn−/− mice display many of the key KPTN-related disorder phenotypes, including brain overgrowth, behavioural abnormalities, and cognitive deficits. By assessment of affected individuals, we have identified widespread cognitive deficits (n = 6) and postnatal onset of brain overgrowth (n = 19). By analysing head size data from their parents (n = 24), we have identified a previously unrecognized KPTN dosage-sensitivity, resulting in increased head circumference in heterozygous carriers of pathogenic KPTN variants.Molecular and structural analysis of Kptn−/− mice revealed pathological changes, including differences in brain size, shape and cell numbers primarily due to abnormal postnatal brain development. Both the mouse and differentiated induced pluripotent stem cell models of the disorder display transcriptional and biochemical evidence for altered mTOR pathway signalling, supporting the role of KPTN in regulating mTORC1.By treatment in our KPTN mouse model, we found that the increased mTOR signalling downstream of KPTN is rapamycin sensitive, highlighting possible therapeutic avenues with currently available mTOR inhibitors. These findings place KPTN-related disorder in the broader group of mTORC1-related disorders affecting brain structure, cognitive function and network integrity.Genetics of disease, diagnosis and treatmen
All-sky search for long-duration gravitational wave transients with initial LIGO
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
All-sky search for long-duration gravitational wave transients with initial LIGO
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
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