An approach to F-theory

We consider BPS configurations in theories with two timelike directions from the perspective of the supersymmetry algebra. We show that whereas a BPS state in a theory with one timelike variable must have positive energy, in a theory with two times any BPS state must have positive angular momentum in the timelike plane, in that $Z_{0\tilde{0}}>0$, where $0$ and $\tilde{0}$ are the two timelike directions. We consider some generic BPS solutions of theories with two timelike directions, and then specialise to the study of the (10,2) dimensional superalgebra for which the spinor operators generate 2-forms and 6-forms. We argue that the BPS configurations of this algebra relate to F-theory in the same way that the BPS configurations of the eleven dimensional supersymmetry algebra relate to M-theory. We show that the twelve dimensional theory is one of fundamental 3-branes and 7-branes, along with their dual partners. We then formulate the new intersection rules for these objects. Upon reduction of this system we find the algebraic description of the IIB-branes and the M-branes. Given these correspondences we may begin an algebraic study of F-theory.Comment: 20 pages, no figures, late

Superparticle Models with Tensorial Central Charges

A generalization of the Ferber-Shirafuji formulation of superparticle mechanics is considered. The generalized model describes the dynamics of a superparticle in a superspace extended by tensorial central charge coordinates and commuting twistor-like spinor variables. The D=4 model contains a continuous real parameter $a\geq 0$ and at a=0 reduces to the SU(2,2|1) supertwistor Ferber-Shirafuji model, while at a=1 one gets an OSp(1|8) supertwistor model of ref. [1] (hep-th/9811022) which describes BPS states with all but one unbroken target space supersymmetries. When 0<a<1 the model admits an OSp(2|8) supertwistor description, and when a>1 the supertwistor group becomes OSp(1,1|8). We quantize the model and find that its quantum spectrum consists of massless states of an arbitrary (half)integer helicity. The independent discrete central charge coordinate describes the helicity spectrum. We also outline the generalization of the a=1 model to higher space-time dimensions and demonstrate that in D=3,4,6 and 10, where the quantum states are massless, the extra degrees of freedom (with respect to those of the standard superparticle) parametrize compact manifolds. These compact manifolds can be associated with higher-dimensional helicity states. In particular, in D=10 the additional ``helicity'' manifold is isomorphic to the seven-sphere.Comment: 32 pages, LATEX, no figure

Mothers' Views ofTheir Childbirth Experiences 2 Years Mter Planned Caesarean Versus Planned Vaginal Birth for Breech Presentation at Term, in the International Randomized Term Breech Trial

Objective: To compare mothers' views at 2 years postpartum after participation in a randomized trial of planned Caesarean and planned vaginal birth for a singleton fetus in breech presentation at term.Study Design: In selected centres in the Term Breech Trial, mothers completed a structured questionnaire at approximately 2 years postpartum to assess their likes and dislikes about their childbirth experiences and their views about their intrapartum care and care providers.Results: Of 1159 mothers from 85 centres, 917 (79.1%) completed a follow-up questionnaire at 2 years postpartum. Baseline information was similar for both the planned Caesarean and planned vaginal birth groups. Planned Caesarean was associated with less worry about the baby's health (P < 0.001 ). While other differences were noted in likes and dislikes about their childbirth experiences, women's evaluations of the quality of intrapartum care, the helpfulness of staff, and their involvement in decision-making did not differ in the planned Caesarean delivery and planned vaginal birth groups.Conclusion: Planned mode of delivery influences aspects of women's evaluations of their childbirth experiences but does not affect evaluations of the quality of intrapartum care, support from care providers, or amount of involvement in decision-making

IMILAST \u2013 a community effort to intercompare extratropical cyclone detection and tracking algorithms: assessing method-related uncertainties.

An intercomparison experiment involving 15 commonly used detection and tracking algorithms for extratropical cyclones reveals those cyclone characteristics that are robust between different schemes and those that differ markedly

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

Many clinical trials have evaluated the benefit of long-term use of antiplatelet drugs in reducing the risk of clinical thrombotic events. Aspirin and ticlopidine have been shown to be effective, but both have potentially serious adverse effects. Clopidogrel, a new thienopyridine derivative similar to ticlopidine, is an inhibitor of platelet aggregation induced by adenosine diphosphate. METHODS: CAPRIE was a randomised, blinded, international trial designed to assess the relative efficacy of clopidogrel (75 mg once daily) and aspirin (325 mg once daily) in reducing the risk of a composite outcome cluster of ischaemic stroke, myocardial infarction, or vascular death; their relative safety was also assessed. The population studied comprised subgroups of patients with atherosclerotic vascular disease manifested as either recent ischaemic stroke, recent myocardial infarction, or symptomatic peripheral arterial disease. Patients were followed for 1 to 3 years. FINDINGS: 19,185 patients, with more than 6300 in each of the clinical subgroups, were recruited over 3 years, with a mean follow-up of 1.91 years. There were 1960 first events included in the outcome cluster on which an intention-to-treat analysis showed that patients treated with clopidogrel had an annual 5.32% risk of ischaemic stroke, myocardial infarction, or vascular death compared with 5.83% with aspirin. These rates reflect a statistically significant (p = 0.043) relative-risk reduction of 8.7% in favour of clopidogrel (95% Cl 0.3-16.5). Corresponding on-treatment analysis yielded a relative-risk reduction of 9.4%. There were no major differences in terms of safety. Reported adverse experiences in the clopidogrel and aspirin groups judged to be severe included rash (0.26% vs 0.10%), diarrhoea (0.23% vs 0.11%), upper gastrointestinal discomfort (0.97% vs 1.22%), intracranial haemorrhage (0.33% vs 0.47%), and gastrointestinal haemorrhage (0.52% vs 0.72%), respectively. There were ten (0.10%) patients in the clopidogrel group with significant reductions in neutrophils (< 1.2 x 10(9)/L) and 16 (0.17%) in the aspirin group. INTERPRETATION: Long-term administration of clopidogrel to patients with atherosclerotic vascular disease is more effective than aspirin in reducing the combined risk of ischaemic stroke, myocardial infarction, or vascular death. The overall safety profile of clopidogrel is at least as good as that of medium-dose aspirin