Why Our Hand is not the Whole Deck: Embrace, Acceptance, or Use of Limitations

I investigate with examples limitations that mathematicians accept in research: aesthetic, scientific, and practical, in particular, on what bases such choices are made. Discussion is partly in terms of the ideal agents that Philip Kitcher and Brian Rotman used to analyse mathematical writing

The Semantics of Word Division in Northwest Semitic Writing Systems

Much focus in writing systems research has been on the correspondences on the level of the grapheme/phoneme. Seeking to complement these, this monograph considers the targets of graphic word-level units in natural language, focusing on ancient North West Semitic (NWS) writing systems, principally Hebrew, Aramaic, Phoenician and Ugaritic. While in Modern European languages word division tends to mark-up morphosyntactic elements, in most NWS writing systems word division is argued to target prosodic units, whereby written ‘words’ consist of units which must be pronounced together with a single primary accent or stress. This is opposed to other possibilities including Semantic word division, as seen in Middle Egyptian hieroglyphic.  The monograph starts by considering word division in a source where, unlike the rest of the material considered, the phonology is well represented, the medieval tradition of Tiberian Hebrew and Aramaic. There word division is found to mark-up ‘minimal prosodic words’, i.e. units that must under any circumstances be pronounced together as a single phonological unit. After considering the Sitz im Leben of such a word division strategy, the monograph moves on to compare Tiberian word division with that in early epigraphic NWS, where it is shown that orthographic wordhood has an almost identical distribution. The most economical explanation for this is argued to be that word division has the same underlying basis in NWS writing since the earliest times. Thereafter word division in Ugaritic alphabetic cuneiform is considered, where two word division strategies are identified, corresponding broadly to two genres of text, poetry and prose. 'Poetic' word division is taken as an instance of mainstream ‘prosodic word division’, while the other is morphosyntactic in scope anticipating later word division strategies in Europe by several centuries. Finally, the monograph considers the digital encoding of word division in NWS texts, especially the difficulties, as well as potential solutions to, the problem of marking up texts with overlapping, viz. morphosyntactic and prosodic, analyses

A generalization of Schur-Weyl duality with applications in quantum estimation

Schur-Weyl duality is a powerful tool in representation theory which has many applications to quantum information theory. We provide a generalization of this duality and demonstrate some of its applications. In particular, we use it to develop a general framework for the study of a family of quantum estimation problems wherein one is given n copies of an unknown quantum state according to some prior and the goal is to estimate certain parameters of the given state. In particular, we are interested to know whether collective measurements are useful and if so to find an upper bound on the amount of entanglement which is required to achieve the optimal estimation. In the case of pure states, we show that commutativity of the set of observables that define the estimation problem implies the sufficiency of unentangled measurements.Comment: The published version, Typos corrected, 40 pages, 2 figure

Development of a quantitative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assays

A highly reproducible and sensitive real-time detection assay based on TaqMan technology was developed for the detection of hepatitis B viru

Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy

A new hepatitis B virus variant selected during lamivudine treatment was detected, in which the methionine (rtM204) in the so-called YMDD motif in the C

Aortic cusp extension valvuloplasty with or without tricuspidization in children and adolescents: Long-term results and freedom from aortic valve replacement

ObjectiveAortic cusp extension valvuloplasty is increasingly used in the management of children and adolescents with aortic stenosis or regurgitation. The durability of this approach and the freedom from valve replacement are not well defined. A study was undertaken to investigate outcomes.MethodsFrom July 1987 to November 2008, 142 patients aged less than 19 years underwent aortic cusp extension valvuloplasty in the form of pericardial cusp extension and tricuspidization (when needed). Three patients with truncus arteriosus and severe truncal valve insufficiency were excluded. From the available follow-up data of 139 patients, 50 had bicuspid aortic valves, 40 had congenital aortic valve stenosis, 41 had combined congenital aortic valve stenosis/insufficiency, and 8 had other diagnoses. Median follow-up was 14.4 years (0.1–21.4). Long-term mortality and freedom from aortic valve replacement were studied.ResultsThere were no early, intermediate, or late deaths. Z-values of left ventricular end-diastolic dimension, aortic annulus, aortic sinus diameter, and sinotubular junction diameter before aortic valve replacement were 4.2 ± 3.11, 2.3 ± 1.25, 4.4 ± 1.23, and 1.84 ± 1.28, respectively. During the follow-up period, 64 patients underwent aortic valve reinterventions. The Ross procedure was performed in 32 of 139 patients (23%) undergoing aortic cusp extension valvuloplasty. Other aortic valve replacements were undertaken after 16 aortic cusp extension valvuloplasties (11.5%). Freedom from a second aortic cusp extension valvuloplasty or aortic valve replacement at 18 years was 82.1% ± 4.2% and 60.0% ± 7.2%, respectively.ConclusionAortic cusp extension valvuloplasty is a safe and effective surgical option with excellent survival and good long-term outcomes in children and adolescents. The procedure provides acceptable durability and satisfactory freedom from aortic valve replacement

Wound Healing in Peripheral Arterial Disease: Current and Future Therapy

Wounds secondary to peripheral arterial disease (PAD) result in substantial morbidity and burden to the healthcare industry. To aid in the care of this patient population, knowledge of the disease process and current standards of therapy is paramount for healthcare providers.The future care of these patients and improvement from our existing standards hinges on the active translational research. To implement new technologies and advances in the treatment of PAD-induced wounds and ensure adequate utilization of our current therapies a PAD-wound team is necessary

Zika Virus Outbreak on Curaçao and Bonaire, a Report Based on Laboratory Diagnostics Data

Background: Zika virus (ZIKV) emerged in May 2015 in Brazil, from which it spread to many other countries in Latin America. Cases of ZIKV infection were eventually also reported in Curaçao (January 2016) and Bonaire (February 2016). Methods: In the period of 16 December 2015 until 26 April 2017, serum, EDTA-plasma or urine samples were taken at Medical Laboratory Services (MLS) from patients on Curaçao and tested in qRT-PCR at the Erasmus Medical Centre (EMC) in the Netherlands. Between 17 October 2016 until 26 April 2017 all samples of suspected ZIKV-patients collected on Curaçao, as well as on Bonaire, were tested at MLS. Paired urine and/or serum samples from patients were analyzed for ZIKV shedding kinetics, and compared in terms of sensitivity for ZIKV RNA detection. Furthermore, the age and ge