744 research outputs found
A study on the protective effects of calcium channel blockers against anoxic brain damage
Introduction
It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia!
hypoxia is intimately connected with the cascade of events- including activation of enzymes which give
rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced
damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation
I
occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged
purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which
leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death
of the neurone.
Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to
tissues, and has been widely used for this purpose
The Reaction of a Nitro-Capped Cobalt(III) Cage Complex With Base: the Crystal Structure of a Contracted Cage Complex, and the Mechanism of Its Formation
The synthesis, properties and crystal structure of the cage complex (1-hydroxy-8-methyl-3,6,10,13,15,18-hexaazabicyclo[6.6.5]nonadecane)cobalt(III) chloride hydrate ([Co(Me,OH-absar)] C13.H2O) are reported. The mechanism of the formation of this contracted cavity cage from a nitro-capped hexaazabicycloicosane type cage has been investigated. Treatment of (1-methyl-8-nitro-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane)cobalt(III) chloride ([Co(Me,NO2-sar)] 3+) with excess base in aqueous solution leads initially to rapid (t1/2 < 1 ms) and reversible deprotonation of one coordinated secondary amine. This species undergoes a retro-Mannich type reaction and imine hydrolysis (t1/2 almost-equal-to 90 s). Quenching the reaction with acid gives rise to a pair of isomeric intermediate species which have been isolated and characterized. They have a pendant arm macrocyclic structure, resulting from the loss of a methylene unit from one of the arms of the cap. Heating either isomer in aqueous solution gives the new cage compound with the contracted cap. It is postulated that this occurs through a Nef reaction, resulting in the formation of a ketone which then condenses with the coordinated primary amine. A comparison with the corresponding bicycloicosane analogue indicates a reduced chromophoric cavity size for the contracted cage. The reduction potential of the cobalt(III)/cobalt(II) couple is 170 mV more negative for the smaller cage, and, in the electronic spectrum of the cobalt(III) complex, the d-d transitions are both shifted to higher energy, corresponding to a stronger ligand field
Geometric Transition versus Cascading Solution
We study Vafa's geometric transition and Klebanov - Strassler solution from
various points of view in M-theory. In terms of brane configurations, we show
the detailed equivalences between the two models. In some limits, both models
have an alternative realization as fourfolds in M-theory with appropriate
G-fluxes turned on. We discuss some aspects of the fourfolds including how to
see the transition and a possible extension to the non-supersymmetric case.Comment: 34 pages, LaTex, 2 figures; v2: Some comments added and references
updated. Final version to appear in JHE
Orientifolds of K3 and Calabi-Yau Manifolds with Intersecting D-branes
We investigate orientifolds of type II string theory on K3 and Calabi-Yau
3-folds with intersecting D-branes wrapping special Lagrangian cycles. We
determine quite generically the chiral massless spectrum in terms of
topological invariants and discuss both orbifold examples and algebraic
realizations in detail. Intriguingly, the developed techniques provide an
elegant way to figure out the chiral sector of orientifold models without
computing any explicit string partition function. As a new example we derive a
non-supersymmetric Standard-like Model from an orientifold of type IIA on the
quintic Calabi-Yau 3-fold with wrapped D6-branes. In the case of supersymmetric
intersecting brane models on Calabi-Yau manifolds we discuss the D-term and
F-term potentials, the effective gauge couplings and the Green-Schwarz
mechanism. The mirror symmetric formulation of this construction is provided
within type IIB theory. We finally include a short discussion about the lift of
these models from type IIB on K3 to F-theory and from type IIA on Calabi-Yau
3-folds to M-theory on G_2 manifolds.Comment: 82 pages, harvmac, 5 figures. v2: references added. v3: T^6
orientifold corrected, JHEP versio
Building a Better Racetrack
We find IIb compactifications on Calabi-Yau orientifolds in which all Kahler
moduli are stabilized, along lines suggested by Kachru, Kallosh, Linde and
Trivedi.Comment: 47 pages, 1 figure, harvmac (v2: added references, minor comments,
v3: improved discussion of metastability and explicit flux vacua
Hierarchies from Fluxes in String Compactifications
Warped compactifications with significant warping provide one of the few
known mechanisms for naturally generating large hierarchies of physical scales.
We demonstrate that this mechanism is realizable in string theory, and give
examples involving orientifold compactifications of IIB string theory and
F-theory compactifications on Calabi-Yau four-folds. In each case, the
hierarchy of scales is fixed by a choice of RR and NS fluxes in the compact
manifold. Our solutions involve compactifications of the Klebanov-Strassler
gravity dual to a confining N=1 supersymmetric gauge theory,and the hierarchy
reflects the small scale of chiral symmetry breaking in the dual gauge theory.Comment: 35 pages. v2: minor eqn. and reference change
Scintillation Counters for the D0 Muon Upgrade
We present the results of an upgrade to the D0 muon system. Scintillating
counters have been added to the existing central D0 muon system to provide
rejection for cosmic ray muons and out-of-time background, and to provide
additional fast timing information for muons in an upgraded Tevatron.
Performance and results from the 1994-1996 Tevatron run are presented.Comment: 30 pages, 25 postscript figure
The Cosmological Slingshot Scenario: Myths and Facts
We generalize the Cosmological Slingshot Scenario for a Slingshot brane
moving in a Klebanov-Strassler throat. We show that the horizon and isotropy
problems of standard cosmology are avoided, while the flatness problem is
acceptably alleviated. Regarding the primordial perturbations, we identify
their vacuum state and elucidate the evolution from the quantum to the
classical regimes. Also, we calculate their exact power spectrum showing its
compatibility with current data. We discuss the bouncing solution from a four
dimensional point of view. In this framework the radial and angular motion of
the Slingshot brane are described by two scalar fields. We show that the
bouncing solution for the scale factor in String frame is mapped into a
monotonically increasing (in conformal time) solution in the Einstein frame. We
finally discuss about the regularity of the geometry in Einstein frame.Comment: 16 pages, 2 figs. Major clarifications and references added, version
accepted in Gen. Rel. Grav. (2009
Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV
We report the results of a study of color coherence effects in ppbar
collisions based on data collected by the D0 detector during the 1994-1995 run
of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8
TeV. Initial-to-final state color interference effects are studied by examining
particle distribution patterns in events with a W boson and at least one jet.
The data are compared to Monte Carlo simulations with different color coherence
implementations and to an analytic modified-leading-logarithm perturbative
calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters
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