Possible optical counterpart of PSR J1357-6429

(Abridged) PSR J1357-6429 is a Vela-like radio pulsar that has been recently detected in X-rays and gamma-rays. It powers a compact tail-like X-ray pulsar wind nebula and X-ray-radio plerion associated with an extended TeV source HESS J1356-645. We present our deep optical observations with the Very Large Telescope to search for an optical counterpart of the pulsar and its nebula. We detect a point-like source in V, R, and I bands whose position is within the 1-sigma error circle of the X-ray position of the pulsar, and whose colours are distinct from those of ordinary stars. We consider it as a candidate optical counterpart of the pulsar. If it is indeed the counterpart, its 5-sigma offset from the radio pulsar position, measured about 9 yr earlier, implies that the transverse velocity of the pulsar is in the range of 1600--2000 km s^{-1} at the distance of 2--2.5 kpc, making it the fastest moving pulsar known. The direction of the estimated proper motion coincides with the extension of the pulsar's X-ray tail, suggesting that this is a jet. The tentative optical luminosity and efficiency of the pulsar are similar to those of the Vela pulsar, which also supports the optical identification. However, the candidate undergoes an unusually steep dereddened flux increase towards the infrared with a spectral index of about 5, that is not typical of optical pulsars. It implies a strong double-knee spectral break in the pulsar emission between the optical and X-rays. The reasons for the spectral steepness are unclear. It may be caused by a nebula knot projected onto the jet and strongly overlapping with the pulsar, as observed for the Crab, where the knot has a significantly steeper spectrum than the pulsar. We find no other signs of the pulsar nebula in the optical. Alternatively, the detected source may be a faint AGN, that has not yet been seen at other wavelengths.Comment: 13 pages, 10 figures, 4 table

The G292.0+1.8 pulsar wind nebula in the mid-infrared

G292.0+1.8 is a Cas A-like supernova remnant that contains the young pulsar PSR J1124-5916 powering a compact torus-like pulsar wind nebula visible in X-rays. A likely counterpart to the nebula has been detected in the optical VRI bands. To confirm the counterpart candidate nature, we examined archival mid-infrared data obtained with the Spitzer Space Telescope. Broad-band images taken at 4.5, 8, 24, and 70 microns were analyzed and compared with available optical and X-ray data. The extended counterpart candidate is firmly detected in the 4.5 and 8 micron bands. It is brighter and more extended in the bands than in the optical, and its position and morphology agree well with the coordinates and morphology of the torus-like pulsar wind nebula in X-rays. The source is not visible in 24 and 70 micron images, which are dominated by bright emission from the remnant shell and filaments. We compiled the infrared fluxes of the nebula, which probably contains a contribution from an unresolved pulsar in its center, with the optical and X-ray data. The resulting unabsorbed multiwavelength spectrum is described by power laws of significantly steeper slope in the infrared-optical than in X-rays, implying a double-knee spectral break between the optical and X-rays. The 24 and 70 microns flux upper limits suggest a second break and a flatter spectrum at the long wavelength limit. These features are common to two other pulsar wind nebulae associated with the remnants B0540-69.3 and 3C 58 and observed in all three ranges. The position, morphology, and spectral properties of the detected source allow us to comfirm that it is the infrared-optical counterpart to both the pulsar and its wind nebula system in the G292.0+1.8 supernova remnant.Comment: 5 pages, 2 figure

APPLICATION OF BALLOON ANGIOPLASTY OF ARTERIES FOR TREATMENT OF DIABETIC FOOT SYNDROME IN PATIENTS IN BURYAT REPUBLIC

The report describes experience of treatment of diabetic foot syndrome over the period of 2009-2011. It demonstrates statistic analysis of lesions of arteries of lower extremities, and also frequency of surgical correction of purulent-necrotic lesions of extremities

Pharmacological preconditioning by incretinomimetics exenatide and vildagliptin: decrement of liver ischemia-reperfusion injury

Study of hepatoprotective activity of exenatide and vildagliptin on the liver ischemia/reperfusion model, taking into account biochemical and morphological parameter

Effect of multipotent mesenchymal stromal cells secretome on imiquimod-induced psoriasis in rats

Multipotent mesenchymal stromal cells secretome contains a range of anti-inflammatory factors and can be used for the treatment of psoriasi

Some problematic issues of rehabilitation of patients with the stroke consequences at the present stage

Background. Acute cerebrovascular disorders are one of the main causes of severe disability in modern society. Russian and foreign researchers register the emerging trend towards rejuvenation of the patients with stroke, which, in turn, significantly increases the relevance of the treatment and rehabilitation of these patients at various stages.The aim. To study the social and hygienic characteristics of the stroke patients and to determine their need for medical rehabilitation in the early recovery period.Materials and methods. We studied the social and hygienic characteristics of 109 patients who had stroke in 2020 and 2021 and underwent rehabilitation in the specialized rehabilitation department of the Southern District Medical Center of the Federal Medical and Biological Agency, and determined their need for medical rehabilitation using the analytical method, the method of expert assessments and questionnaires.Results. The average portrait of a patient with a stroke in the early recovery period is as follows: this is a man aged 61 to 70 years with a higher or secondary specialized education, unemployed, living in the city. Up to 30 % of stroke survivors were recognized as disabled; among which, the persons with more severe disability (groups I and II) predominate – up to 90 %. Implementation of rehabilitation measures in the acute period in the hospital and in the early recovery period in the outpatient clinic is carried out at a fairly low level. The percentage of patients being examined by a multidisciplinary rehabilitation team ranges from 17.4 to 10.1 %.Conclusion. The availability of medical rehabilitation measures in a specialized rehabilitation center is quite limited; more than half of the surveyed contingent (52.3 %) experienced problems in obtaining a referral to treatment, about half of the respondents (46.8 %) waited up to 6 months for a referral, which indicates the need to expand the network of such institutions at the regional level

SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia

Depressive disorder (DD) is a widespread mental disorder. Although DD is to some extent inherited, the genes contributing to the risk of this disorder and its genetic mechanisms remain poorly understood. A recent large-scale genome-wide association Chinese study revealed a strong association between the SIRT1 gene variants and DD. The aim of this study was to analyze the occurrence of heterozygote carriers and search for rare SNP variants of the SIRT1 gene in a cohort of DD patients as compared with a cohort of randomly selected members of the Russian population. The complete coding sequences of the SIRT1 gene from 1024 DNA samples from the general Russian population and from 244 samples from patients with DD were analyzed using targeted sequencing. Four new genetic variants of the SIRT1 were discovered. While no significant differences in the allele frequencies were found between the DD patients and the general population, differences between the frequencies of homozygote carriers of specific alleles and occurrences of heterozygous were found to be significant for rs2236318 (P < 0.0001), and putatively, rs7896005 (P < 0.05), and rs36107781 (P < 0.05). The study found for the first time that two new SNPs (i.e., 10:69665829 and 10:69665971) along with recently reported ones (rs773025707 and rs34701705), are putatively associated with DD. The revealed DD-associated SIRT1 SNPs might confer susceptibility to this disorder in Russian population of European descent

Скоростные показатели вентиляционной функции легких и бронхиальное сопротивление при внебольничных пневмониях

36 community-acquired pneumonia (CAP) patients were examined with respect to speed indices of ventilatory pulmonary function and bronchial resistance Raw . 19 patients had due values of the above-listed indices. When these indices decreased, 17 patients had Raw value within due limits. Therefore, the obstructive type of ventilation embarrassment in the course of CAP is not an evidence of Raw .У 36 пациентов внебольничной пневмонией (ВП) определяли скоростные показатели вентиляционной функции легких и бронхиальное сопротивление Raw . Перечисленные показатели соответствовали норме у 19 из них. У 17 больных при снижении скоростных показателей вентиляции Raw было в пределах должных величин, поэтому обструктивный тип нарушения вентиляции легких при ВП не являлся проявлением нарушения бронхиальной проходимости