INHIBITORS OF ANGIOGENESIS IN BRAIN TUMORS – REVIEW

Malignant glial and metastatic tumors are highly vascularized tumors and like all solid tumors, they require angiogenesis for their growth. [1] For glioblastoma (GBM) this microvascularization is very likely and those vessels have abnormal structure, shape and organization.[2] The permeability of those blood vessels is high and very variable in space and time.[3, 4] This abnormal permeability and aberrant morphologic vascularnetworkare associated with abnormal - blood flow, oxygen and nutrients delivery, and also decreased delivery of applied systemic medications.[5] The microenviorment of the tumor has zones of hypoxia, interstitial hypertension and necrosis.[6, 7, 8, 9, 10] According to Hobbs et al., when the tumor’diameter reaches 1-2mm,the integrity of blood brain barrier (BBB) is structurally and functionally impaired. The abnormal permeability and еfflux can be visualized on MRI/CT scan imaging as enchancement of the contrast

Suitability of òhe modality virtual bronchoscopy with aspiration of a foreign body

Aspirations of foreign bodies are life-threatening among children and elderly patients requiring urgent medical assistance. The aim of the study is to present summarized results from various authors' studies to reveal VB's diagnostic abilities for suspected aspiration of a foreign body. VB has been shown to be a particularly useful non-invasive modality for the complex tracheobronchial tree assessment for suspected aspiration of a foreign body due to its high sensitivity, specificity and validity. MDCT VB with MPR allows accurate localization of the foreign body, but in secondary inflammatory changes and secretions it does not provide accurate information about the form and type of the finding. VB cannot replace FB ("gold standard") but successfully supports and complements it. MDCT could provide early diagnosis in cases of suspected aspiration of a foreign body in children and adults and avoid real bronchoscopy in patients with poor overall condition

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1

Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Their incidence has increased dramatically during recent years, probably due to the different sexual habits and changes in the prevalence of HIV/ AIDS and HPV virus carriers, among other factors. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety eight percent of all vulvar tumors are benign and only 2% are malignant. The overall incidence of tumors with vulvar location is between two and seven cases per 100,000 women, and it increases with age, while the death rate is estimated at 0.7 per 100,000 women. Sarcomas of the vulva comprise approximately 1–3% of all vulvar cancers, with leiomyosarcomas, epithelioid sarcomas, and rhabdomyosarcomas being the most common among them. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In this paper, we present the most common forms of sarcomas of the vulva (leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, rhabdomyosarcoma) in order to emphasize the broad differential diagnosis, rare appearance, non-specific clinical picture, aggressive course, and high mortality

The Role of Regulatory Capital in International Bank Mergers and Acquisitions

When investigating the role of regulatory capital in bank mergers and acquisitions (m&as) we finds that us targets are better capitalized than their acquirers and non-acquired peers and that us banks maintain higher capital levels than european banks. Thus, us banks strategically raise their capital levels to avoid regulatory scrutiny. Furthermore, more value is created for targets with high excess capital and in m&as involving targets with considerably higher excess-capital ratios than their acquirers. Thus, the excess regulatory capital hypothesis is supported. Finally, market prices reflect the influence that capital has on the probability of the merger's regulatory approval

Electrochemical Deposition of Silver on Aluminum Alloys

Silver coatings have a very high reflection ability. To avoid their darkening from the hydrogen sulphide in the air, a thin layer of heat-resistant colorless lacquer is applied to the coatings. Silver plating is mainly used in jewelery, optics, electronics and electrical engineering. Depending on their application the thickness of the layer may vary from 2 to 24 μm. It can be done in several ways: chemical, electrochemical, contact, etc. The most common way of silver plating is the electrochemical deposition using cyanide and non-cyanide electrolytes. The cyanide electrolytes produce light, fine crystalline, dense and plastic coatings upon silver-plating. Usually silver coatings are applied with copper or nickel intermediate layer. In order to improve the de-oxidation of the aluminum surface new chemical treatment in acid – alkaline solution was applied. Our previous research shows that the presence of diamond nanoparticles in the electrolyte increase the metal deposition. Samples were prepared from electrolyte containing 10 g/l diamond nanoparticles. Their properties were compared to the properties of reference samples. The diamonds were obtained by detonation synthesis. The aim of this study is to obtain electrochemically deposited silver layer with high density, adhesion and electric conductivity on aluminum alloys substrate. The coating was directly plated without intermediate layer. Non-cyanide electrolyte composition and electrochemical parameters were determined in order to produce Ag coatings on Al alloy substrate without intermediate layer. The coating is with good adhesion, density and thickness of 14-23 μm