Improving Undergraduate Learning For Employability Through International Exposure

The purpose of this study is to identify how undergraduate business programs can incorporate international exposure to increase employability among its graduates. We first examine how international opportunities in corporations have impacted the skills needed by employees to excel in a globalized work environment. From this, we identify desirable employee characteristics. Next, we discuss the research methodology to determine how highly ranked undergraduate business programs are adapting to employer demands. A four-tiered research approach is used to: identify criteria for measurement; select top undergraduate business programs for assessment; research university websites for curriculum requirements; and confirm observations directly with institutions. The findings show how universities have adapted undergraduate learning experiences to incorporate global exposure to help ensure graduates possess the required skills for employability. Finally, we discuss what characteristics many undergraduate business programs may lack in terms of international exposure and offer suggestions on how they could improve. This study should be of interest to university faculty and administrators by providing practical implications to aid undergraduate business programs in adopting initiatives, courses, and opportunities to stress an international focus for students. Introducing global education to a business curriculum could improve graduate job placement and improve a business program’s overall ranking to external constituencies

Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion

A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations. However, unlike other children with hyperinsulinism, this patient had a persistently elevated blood spot hydroxybutyrylcarnitine concentration when fed, as well as when fasted. Measurement of the activity of L-3-hydroxyacyl-CoA dehydrogenase in cultured skin fibroblasts with acetoacetyl-CoA substrate showed reduced activity. In fibroblast mitochondria, the activity was less than 5% that of controls. Sequencing of the short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) genomic DNA from the fibroblasts showed a homozygous mutation (C773T) changing proline to leucine at amino acid 258. Analysis of blood from the parents showed they were heterozygous for this mutation. Western blot studies showed undetectable levels of immunoreactive SCHAD protein in the child's fibroblasts. Expression studies showed that the P258L enzyme had no catalytic activity. We conclude that C773T is a disease-causing SCHAD mutation. This is the first defect in fatty acid beta -oxidation that has been associated with hyperinsulinism and raises interesting questions about the ways in which changes in fatty acid and ketone body metabolism modulate insulin secretion by the beta cell. The patient's hyperinsulinism was easily controlled with diazoxide and chlorothiazide

Integrated waveguides and deterministically positioned nitrogen vacancy centers in diamond created by femtosecond laser writing

Diamond's nitrogen vacancy (NV) center is an optically active defect with long spin coherence times, showing great potential for both efficient nanoscale magnetometry and quantum information processing schemes. Recently, both the formation of buried 3D optical waveguides and high quality single NVs in diamond were demonstrated using the versatile femtosecond laser-writing technique. However, until now, combining these technologies has been an outstanding challenge. In this work, we fabricate laser written photonic waveguides in quantum grade diamond which are aligned to within micron resolution to single laser-written NVs, enabling an integrated platform providing deterministically positioned waveguide-coupled NVs. This fabrication technology opens the way towards on-chip optical routing of single photons between NVs and optically integrated spin-based sensing

Red Flags in Family History and Auscultations that may require 12-Lead ECG when Screening Athletes

The main components of pre-participation physical exams (PPE) at the NCAA Division II level include a thorough medical history and physical evaluation (AHA). “Red flags” for risk on the PPE and medical history include, but are not limited to, heart murmur, diagnosed enlarged heart in a family member, unexplained chest pain, and complaints of skipped heartbeats. The purpose of this investigation was to determine if the use of 12-lead ECG for the PPE would reveal further red flags specific to cardiac abnormalities. Twelve-lead electrocardiogram (ECG) was performed on all new athletes at Tarleton State University during the Summer and Fall 2012 (N=200). Twelve-lead ECGs were reviewed and analyzed by the lab director and attending physician. Upon completion of the PPE, medical history, and ECG, five athletes needed follow-up based on PPE and 12-lead ECG. Reasons for initial concern were the previously stated “red flags” as well as abnormal ECG readings. The abnormal ECG readings included left ventricular hypertrophy (LVH), incomplete right bundle branch block (IRBBB), sinus arrhythmia, and right atrial enlargement (RAE). LVH, IRBB, and sinus arrhythmia were all found to be normal training induced adaptations, however RAE is a non-training induced cardiac abnormality. Of those five, all of them had some type of cardiac adaptation, but one of them presented with RAE. The athlete was an 18-year old male, 64.5” tall, 116 pounds, and in his first year of collegiate cross-country athletics. His HR was 81bpm and blood pressure was 122/72 mmHg. His grandmother was diagnosed with an enlarged heart. The clearing physician, an orthopedic doctor, found only training induced abnormalities in all five athletes. All five athletes were cleared for competition. Endurance athletes often have abnormal ECG readings as a result of training induced abnormalities. In the present investigation, an athlete with RAE competed for an entire cross-country season without any issues or complaints. Physicians trained in reading ECGs should be responsible for clearing athletes for participation. In this case, right atrial enlargement appeared in the ECG, yet the orthopedic doctor did not request follow up tests. Physicians who are versed in exercise training induced changes that might be classified as normal or abnormal should be the final step in clearing athletes for competition

Polarized micro-Raman studies of femtosecond laser written stress-induced optical waveguides in diamond

Understanding the physical mechanisms of the refractive index modulation induced by femtosecond laser writing is crucial for tailoring the properties of the resulting optical waveguides. In this work we apply polarized Raman spectroscopy to study the origin of stress-induced waveguides in diamond, produced by femtosecond laser writing. The change in the refractive index induced by the femtosecond laser in the crystal is derived from the measured stress in the waveguides. The results help to explain the waveguide polarization sensitive guiding mechanism, as well as providing a technique for their optimization.Comment: 5 pages, 4 figure

Generalized Plasmonic Modelling of the Effect of Refractive Index on Laser-Induced Periodic Nanostructures

Laser-induced periodic surface structures (LIPSS) have been studied theoretically employing generalized plasmonic modelling on several dielectric materials such as SiO2, Al2O3, ZnO, AlAs and diamond exposed to 800 nm wavelength multi-pulse femtosecond laser irradiation. The study of the optical properties of the materials during laser irradiation reveals a formation of a metallic like pseudo-material on the irradiated layer during excitation. A study of the grating periodicity of the nanostructures shows that the materials having a high refraction index allow LIPSS formation with a wide range of grating periodicities. Results also show High Spatial Frequency LIPSS formation with periodicities 3 to 8 times lower than the laser wavelength

Uso de pastejo rotacionado em uma área de pastagem nativa no Pantanal.

Para evitar desmatamento e proteger a biodiversidade, áreas consideradas produtivas podem ser manejadas de forma mais eficiente e rentável, para não haver necessidade de novos desmatamentos. Com essa finalidade, a WCS Brasil trabalha com a comunidade rural promovendo melhores práticas para otimizar a utilização e a rentabilidade das áreas produtivas, minimizando as pressões sobre os recursos naturais

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency

Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells. We previously demonstrated that VPA_ AFS cells, human amniocytes cultivated with valproic acid (VPA) acquired functional pluripotency while remaining distinct from human embryonic stem cells (hESCs), questioning the relationship between the modulation of cell fate and molecular regulation of the pluripotency network. Here, we used single-cell analysis and functional assays to reveal that VPA treatment resulted in a homogeneous population of self-renewing non-transformed cells that fulfill the hallmarks of pluripotency, i.e., a short G1 phase, a dependence on glycolytic metabolism, expression of epigenetic modifications on histones 3 and 4, and reactivation of endogenous OCT4 and downstream targets at a lower level than that observed in hESCs. Mechanistic insights into the process of VPA-induced reprogramming revealed that it was dependent on OCT4 promoter activation, which was achieved independently of the PI3K (phosphatidylinositol 3-kinase)/ AKT/ mTOR (mammalian target of rapamycin) pathway or GSK3 beta inhibition but was concomitant with the presence of acetylated histones H3K9 and H3K56, which promote pluripotency. Our data identify, for the first time, the pluripotent transcriptional and molecular signature and metabolic status of human chemically induced pluripotent stem cells

How is research publishing going to progress in the next 20 years?:Transcription of Session for Editors, Associate Editors, Publishers and Others with an Interest in Scientific Publishing Held at IADR Meeting In Seattle on Wednesday, 20 March 2013

On March 20th 2013, a one‐hour session for E ditors, A ssociate Editors, P ublishers and others with an interest in scientific publishing was held at the IADR I nternational S ession in Seattle. Organised by K enneth E aton and C hris L ynch ( C hair and S ecretary, respectively, of the B ritish D ental E ditors F orum), the meeting sought to bring together leading international experts in dental publishing, as well as authors, reviewers and students engaged in research. The meeting was an overwhelming success, with more than 100 attendees. A panel involving four leading dental editors led a discussion on anticipated developments in publishing dental research with much involvement and contribution from audience members. This was the third such meeting held at the IADR for E ditors, A ssociate E ditors, P ublishers and others with an interest in scientific publishing. A follow up session will take place in C ape T own on 25 J une 2014 as part of the annual IADR meeting. The transcript of the meeting is reproduced in this article. Where possible speakers are identified by name. At the first time of mention their role/ position is also stated, thereafter only their name appears. We are grateful to S tephen H ancocks Ltd for their generous sponsorship of this event. For those who were not able to attend the authors hope this article gives a flavour of the discussions and will encourage colleagues to attend future events. Involvement is open to E ditors, A ssociate E ditors, Publishers and others with an interest in scientific publishing. It is a very open group and all those with an interest will be welcome to join in.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106931/1/eje12089.pd