Transcutaneous vagus nerve stimulation via tragus or cymba conchae: Are its psychophysiological effects dependent on the stimulation area?

Efforts in optimizing transcutaneous vagus nerve stimulation (tVNS) are crucial to further develop its potential in improving cognitive and autonomic regulation. The present study focused on this topic. The aim was to compare for the first time the main stimulation areas of the ear currently used in studies with tVNS, taking cognitive as well as neurophysiological effects into account. The main areas to be compared with one another were tragus, cymba conchae, and earlobe (sham) stimulation. Post-error slowing, which has already been shown to be influenced by tVNS, was used to investigate the cognitive effects of tVNS when applied on the different auricular areas. On the neurophysiological level, we measured pupillary responses as an index of norepinephrine activity during post-error slowing, and cardiac vagal activity to investigate the activation of neural pathways involved in post-error slowing. Stimulation of different auricular areas led to no differences in post-error slowing and in pupillary responses. However, the neurological processes involved in post-error slowing could be observed, since norepinephrine activity increased after committing an error. Further, there was an increase in cardiac vagal activity over the test period that was independent of the stimulation areas. The results suggest that tVNS targeting the ear might have a non-specific effect on the processing of error commission, on pupillary responses, and on cardiac vagal activity. We conclude that it is necessary to consider alternatives for sham conditions other than electrical earlobe stimulation. [Abstract copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

The measurement of lubricant-film thickness using ultrasound

Ultrasound is reflected from a liquid layer between two solid bodies. This reflection depends on the ultrasonic frequency, the acoustic properties of the liquid and solid, and the layer thickness. If the wavelength is much greater than the liquid-layer thickness, then the response is governed by the stiffness of the layer. If the wavelength and layer thickness are similar, then the interaction of ultrasound with the layer is controlled by its resonant behaviour. This stiffness governed response and resonant response can be used to determine the thickness of the liquid layer, if the other parameters are known. In this paper, ultrasound has been developed as a method to determine the thickness of lubricating films in bearing systems. An ultrasonic transducer is positioned on the outside of a bearing shell such that the wave is focused on the lubricant-film layer. The transducer is used to both emit and receive wide-band ultrasonic pulses. For a particular lubricant film, the reflected pulse is processed to give a reflection-coefficient spectrum. The lubricant-film thickness is then obtained from either the layer stiffness or the resonant frequency. The method has been validated using fluid wedges at ambient pressure between flat and curved surfaces. Experiments on the elastohydrodynamic film formed between a sliding ball and a flat surface were performed. Film-thickness values in the range 50-500 nm were recorded, which agreed well with theoretical film-formation predictions. Similar measurements have been made on the oil film between the balls and outer raceway of a deep-groove ball bearing

The nature and measurement of sustaining attention over time: The influence of cognitive ability, internal distraction, arousal, and motivation on sustained attention

It is evident that it takes a great deal of effort to sustain our attention on any one thing over a period of minutes or even seconds. This ability to sustain attention is critical for many everyday tasks and is often seen as a fundamental factor underlying differences in cognitive ability. Therefore, it is important to understand the factors that determine how long we can voluntarily sustain our attention. Across two studies I used a novel task, the sustained attention- to-cue task (SACT), to assess sustained attention. The critical element of the task is to sustain attention at a cued location for a variable amount of time (0 – 12 seconds). In Study 1, I investigated how individual differences in cognitive ability are related to sustained attention. I found that those higher on attention control showed less of a decline in performance the longer attention had to be sustained. However, sustained attention performance was not related to working memory capacity or fluid intelligence. In Study 2, I investigated how susceptibility to distraction, changes in arousal, and motivation are related to sustained attention performance on the SACT. Overall, there was a large decline in attention on a shorter timescale based on performance, eye gaze, pupil size, and mind wandering measures. There were no changes in attention at a longer timescale, however there was strong evidence that arousal declined over the course of the task. Reward and motivation lead to improvements in attention overall and motivation led to improvements in sustained attention at a shorter timescale. In general, these findings suggest that attention can fluctuate and wane over a relatively short time scale of around 10 seconds or less and that this is related to individual differences in attention control, distractibility, arousal, and motivation.Ph.D

Low Reynolds number turbulent flows over elastic walls

We study the laminar and turbulent channel flow over a viscous hyper-elastic wall and show that it is possible to sustain an unsteady chaotic turbulent-like flow at any Reynolds number by properly choosing the wall elastic modulus. We propose a physical explanation for this effect by evaluating the shear stress and the turbulent kinetic energy budget in the fluid and elastic layer. We vary the bulk Reynolds number from 2800 to 10 and identify two distinct mechanisms for turbulence production. At moderate and high Reynolds numbers, turbulent fluctuations activate the wall oscillations, which, in turn, amplify the turbulent Reynolds stresses in the fluid. At very low Reynolds number, the only production term is due to the energy input from the elastic wall, which increases with the wall elasticity. This mechanism may be exploited to passively enhance mixing in microfluidic devices

A supercritical series analysis for the generalized contact process with diffusion

We study a model that generalizes the CP with diffusion. An additional transition is included in the model so that at a particular point of its phase diagram a crossover from the directed percolation to the compact directed percolation class will happen. We are particularly interested in the effect of diffusion on the properties of the crossover between the universality classes. To address this point, we develop a supercritical series expansion for the ultimate survival probability and analyse this series using d-log Pad\'e and partial differential approximants. We also obtain approximate solutions in the one- and two-site dynamical mean-field approximations. We find evidences that, at variance to what happens in mean-field approximations, the crossover exponent remains close to $\phi=2$ even for quite high diffusion rates, and therefore the critical line in the neighborhood of the multicritical point apparently does not reproduce the mean-field result (which leads to $\phi=0$) as the diffusion rate grows without bound

Pseudo-monoamniotic Pregnancy: Case Report and Review of Etiologic Considerations

Pseudomonoamniotic gestations are increasingly recognized through sonographic surveillance of monochorionic twins, though etiologic factors remain undefined. We present a case of spontaneous pseudomonoamniotic twins and propose umbilical cord insertion proximity as a sonographic marker. Systematic review of the literature was performed and additional cases with similar findings were noted. Approximately 75% of reported cases (28/37) were deemed spontaneous and several included short inter-cord distances. Shunting of blood away from the membranes in the region between the cord insertions may be responsible for membrane rupture. Further investigation is needed into short inter-cord distance as a marker for monochorionic twins at risk to become a pseudomonoamniotic gestation

Strong Approximation of Empirical Copula Processes by Gaussian Processes

We provide the strong approximation of empirical copula processes by a Gaussian process. In addition we establish a strong approximation of the smoothed empirical copula processes and a law of iterated logarithm

In vivo immunological toxicity in mice of carbon nanotubes with impurities

ArticleCarbon. 47(5):1365-1372 (2009)journal articl

Successful transplantation and in vitro expansion of human retinal pigment epithelium and its characterization; a step towards cell-based therapy for age-related macular degeneration.

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