Hydromagnetic stability of the magnetosphere boundary

Hydromagnetic stability of magnetosphere-solar wind interfac

Two-stream instability in gravitating plasmas with magnetic field and rotation

Gas stream instability investigated using moment equations in gravitating plasma clouds with magnetic field and uniform rotation - plasma physic

Magnetogravitational instability of anisotropic plasma with Hall effect

Magnetogravitational instability of anisotropic plasma with Hall effec

Adjunctive strategies in the management of resistant, 'undilatable' coronary lesions after successfully crossing a CTO with a guidewire.

Successful revascularisation of chronic total occlusions (CTOs) remains one of the greatest challenges in the era of contemporary percutaneous coronary intervention (PCI). Such lesions are encountered with increasing frequency in current clinical practice. A predictable increase in the future burden of CTO management can be anticipated given the ageing population, increased rates of renal failure, graft failure and diabetes mellitus. Given recent advances and developments in CTO PCI management, successful recanalisation can be anticipated in the majority of procedures undertaken at high-volume centres when performed by expert operators. Despite advances in device technology, the management of resistant, calcific lesions remains one of the greatest challenges in successful CTO intervention. Established techniques to modify calcific lesions include the use of high-pressure non-compliant balloon dilation, cutting-balloons, anchor balloons and high speed rotational atherectomy (HSRA). Novel approaches have proven to be safe and technically feasible where standard approaches have failed. A step-wise progression of strategies is demonstrated, from well-recognised techniques to techniques that should only be considered when standard manoeuvres have proven unsuccessful. These methods will be described in the setting of clinical examples and include use of very high-pressure non-compliant balloon dilation, intentional balloon rupture with vessel dissection or balloon assisted micro-dissection (BAM), excimer coronary laser atherectomy (ECLA) and use of HSRA in various 'offlabel' settings

Seeing double: the low-carb diet

No abstract available

Chimerism monitoring following allogeneic hematopoietic stem cell transplantation

Information regarding the chimeric status of hematopoietic stem cell transplantation (HSCT) recipients is of great significance when comparing different conditioning and prophylactic therapies. In recent years, short tandem repeats/variable number tandem repeats (STRs/VNTRs) have emerged as the best tool for chimerism monitoring. However, the polymorphisms of STR/VNTR markers vary within and between ethnic groups. The issue is further complicated in a heterogeneous population such as occurs in the Indian subcontinent. In the present study, we attempted to devise a robust scheme to identify a set of polymorphic STRs/VNTRs most suitable for chimerism evaluation in north Indian HCST recipients. At first, we did genotyping of 11 STR and one VNTR in 1000 randomly chosen north Indian individuals to quantify different diversity parameters. Resulting data indicated that ApoB3'HVR, FES, VWA, D3S1358 and D16S310 were most polymorphic loci with the average heterozygosity being 0.756± 0.17. Furthermore, all markers were genotyped in 77 HLA-matched donor-recipient pairs to evaluate the informativeness in differentiating donor's and recipient's cells. A panel of seven markers (ApoB3HVR-D3S1358-HUM-THO1-VWF-1-D16S310-FES-VWA) differentiated 98.70% of donor-recipient pairs. This set of markers also successfully monitored the graft status in 14 HSCT cases during multiple time points following HSCT. The results were compared to the commercially available AmpF/STR SGM Plus multiplex PCR kit (Applied Biosystems, Foster City, CA, USA). Our findings established that the panel of seven markers we identified was more cost-effective and informative

1.5 °C pathways for the Global Industry Classification (GICS) sectors chemicals, aluminium, and steel.

To achieve the goals of the Paris Climate Agreement, decarbonization targets and benchmarks for specific industry sectors are required. This opens up a whole new research area for energy modelling because although decarbonization pathways have been developed for countries, regions, or communities, few have been developed for industry sectors. In this research, we document the development of energy scenarios for industry sectors classified under the Global Industry Classification Standard (GICS). A bottom-up energy demand analysis based on market projections for the chemical, aluminium, and steel industries forms the basis for scenario development, with the aim of completely decarbonizing the electricity and process heat supplies for these industries by 2050. We document the individual steps in the energy demand analyses based on industry-specific market projections and energy intensities. In the last step, the carbon budget is calculated. The complete decarbonization of the industries analysed seems possible based on the available technology. Supplementary Information: The online version contains supplementary material available at 10.1007/s42452-022-05004-0

Different strokes for different folks: Comparative analysis of 3D printing in large, medium and small firms

Industry 4.0 technologies such as 3D printing have radically transformed innovative outcomes for firms in terms of product design and offerings in the recent past. Acknowledging the impact, existing scholarship has delved into different dimensions of this technology and outcomes of its adoption, yet when compared with the scale of industrial activity globally and the varied possibilities associated with the adoption of this relatively new technology, the literature is woefully lean. Discussions and conversations on facilitators and inhibitors of adoption and continued usage are still nascent, particularly when one ponders upon specific insights related to sectors and firm size. The present study seeks to address this paucity by using the lens of firm size. Specifically, the study examines how firm size impacts various positive and negative outcomes of industry 4.0 innovation adoption and usage using 3D printing as an exemplar. Toward this end, we conducted a qualitative study to collect responses from 46 managers, 23 each from large-size and small-size enterprises operating in the United Kingdom. Thematic coding of responses revealed five aggregate dimensions representing facilitators and four aggregate dimensions representing inhibitors. Analysis of the findings revealed differences in outcomes with firm size, indicating that the adoption and optimal use of innovations such as 3D printing were indeed incumbent on firm size in the case of disruptive, technology-driven innovations that are generically presumed to have positive outcomes. Overall, the findings of this study provide new insights into various facilitators and inhibitors of the adoption of 3D printing technology, which can help firms to make better strategic decisions on the effective usage of this technology

Properties and characteristics of an anti-human chorionic gonadotropin monoclonal antibody

The product of a hybrid cell clone, P3W80, obtained as ascites fluid from mouse peritoneal cavity had high titres of anti-human chorionic gonadotropin antibodies e.g. 30 to 40% binding of 125I-human chorionic gonadotropin at 107 dilution in a radioimmunoassay. The antiserum SB6 (raised against β-human chorionic gonadotropin distributed by National Institutes of Health, USA gave similar binding at 5000 dilution in parallel runs. The monoclonal antibody recognized best human chorionic gonadotropin (0.3 mlU of hormone/tube with B/B0 < 75%), but also bound β and α subunits of human chorionic gonadotropin, 12 and 800 folds lower than human chorionic gonadotropin respectively No binding was observed with carboxy terminal peptides of β-human chorionic gonadotropin ranging from 93 to 145 amino acid residues, indicating the lack of recognition of the C-terminal region. No cross-reaction with human leutinizing hormone was obtained at the physiological surge levels, a significant competition (B/B0 < 75 %. obtainable only at 60 mlU of LER 960 human leutinizing hormone/ tube. The antibody had heavy chain of IgG1 and light chain of kappa type. It neutralized the bio-activity of human chorionic gonadotropin bothin vitro and invivo