2,057 research outputs found
Prostate cancer radiotherapy: potential applications of metal nanoparticles for imaging and therapy
Prostate cancer (CaP) is the most commonly diagnosed cancer in males. There have been dramatic technical advances in radiotherapy delivery, enabling higher doses of radiotherapy to primary cancer, involved lymph nodes and oligometastases with acceptable normal tissue toxicity. Despite this, many patients relapse following primary radical therapy, and novel treatment approaches are required. Metal nanoparticles are agents that promise to improve diagnostic imaging and image-guided radiotherapy and to selectively enhance radiotherapy effectiveness in CaP. We summarize current radiotherapy treatment approaches for CaP and consider pre-clinical and clinical evidence for metal nanoparticles in this condition
Packing dry whole milk in inert gas
This archival publication may not reflect current scientific knowledge or recommendations.Minnesota Institute of Researc
Epidemiological analysis of methicillin-resistant Staphylococcus aureus isolates from adult patients with cystic fibrosis
Using pulsed-field gel electrophoresis, we genotyped 21 methicillin-resistant Staphylococcus aureus isolates from patients attending an adult cystic fibrosis unit. Eleven patients exhibited pulsotypes related to 2 locally endemic strains. Eleven chronically colonized patients were assessed over a period of up to 2 years, and all demonstrated a retention of strain type
Testing the Universality of the Stellar IMF with Chandra and HST
The stellar initial mass function (IMF), which is often assumed to be
universal across unresolved stellar populations, has recently been suggested to
be "bottom-heavy" for massive ellipticals. In these galaxies, the prevalence of
gravity-sensitive absorption lines (e.g. Na I and Ca II) in their near-IR
spectra implies an excess of low-mass ( ) stars over that
expected from a canonical IMF observed in low-mass ellipticals. A direct
extrapolation of such a bottom-heavy IMF to high stellar masses (
) would lead to a corresponding deficit of neutron stars and black
holes, and therefore of low-mass X-ray binaries (LMXBs), per unit near-IR
luminosity in these galaxies. Peacock et al. (2014) searched for evidence of
this trend and found that the observed number of LMXBs per unit -band
luminosity () was nearly constant. We extend this work using new and
archival Chandra X-ray Observatory (Chandra) and Hubble Space Telescope (HST)
observations of seven low-mass ellipticals where is expected to be the
largest and compare these data with a variety of IMF models to test which are
consistent with the observed . We reproduce the result of Peacock et al.
(2014), strengthening the constraint that the slope of the IMF at
must be consistent with a Kroupa-like IMF. We construct an IMF model
that is a linear combination of a Milky Way-like IMF and a broken power-law
IMF, with a steep slope ( ) for stars < 0.5 (as
suggested by near-IR indices), and that flattens out ( ) for
stars > 0.5 , and discuss its wider ramifications and limitations.Comment: Accepted for publication in ApJ; 7 pages, 2 figures, 1 tabl
Preventing "Sticky-Crumbly" Butter
This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu
Working group written presentation: Trapped radiation effects
The results of the Trapped Radiation Effects Panel for the Space Environmental Effects on Materials Workshop are presented. The needs of the space community for new data regarding effects of the space environment on materials, including electronics are listed. A series of questions asked of each of the panels at the workshop are addressed. Areas of research which should be pursued to satisfy the requirements for better knowledge of the environment and better understanding of the effects of the energetic charged particle environment on new materials and advanced electronics technology are suggested
Recommended from our members
Elevated stratified layers observed during VTMX.
A suite of instrumentation including a minisodar, a low-frequency, single-axis sodar, a wind profiling radar and a tethersonde was used during the Vertical Transport and Mixing field study in Salt Lake City, UT, USA, to study the evolution and dynamics of stratified layers that commonly develop during nighttime. The month-long field study provided ten nights with good conditions for tethersonde flights. The real-time sodar display was used to place the tethersonde within and near the stratified layers and to make multiple transects, while atmospheric temperature, moisture, wind speed and wind direction were measured. Not surprisingly, the existence of layers with enhanced acoustic scattering correlated well with regions of potential temperature inversions; however, because wind speeds were invariably low, the Richardson number was rarely less than 0.25. The possible role of moisture in the dynamics of elevated stable layer is discussed
Lessons from the evaluation of the UK's NHS R&D Implementation Methods Programme
Background: Concern about the effective use of research was a major factor behind the creation
of the NHS R&D Programme in 1991. In 1994, an advisory group was established to identify
research priorities in research implementation. The Implementation Methods Programme (IMP)
flowed from this, and its commissioning group funded 36 projects. In 2000 responsibility for the
programme passed to the National Co-ordinating Centre for NHS Service Delivery and
Organisation R&D, which asked the Health Economics Research Group (HERG), Brunel University,
to conduct an evaluation in 2002. By then most projects had been completed. This evaluation was
intended to cover: the quality of outputs, lessons to be learnt about the communication strategy
and the commissioning process, and the benefits from the projects.
Methods: We adopted a wide range of quantitative and qualitative methods. They included:
documentary analysis, interviews with key actors, questionnaires to the funded lead researchers,
questionnaires to potential users, and desk analysis.
Results: Quantitative assessment of outputs and dissemination revealed that the IMP funded useful
research projects, some of which had considerable impact against the various categories in the
HERG payback model, such as publications, further research, research training, impact on health
policy, and clinical practice.
Qualitative findings from interviews with advisory and commissioning group members indicated
that when the IMP was established, implementation research was a relatively unexplored field. This
was reflected in the understanding brought to their roles by members of the advisory and
commissioning groups, in the way priorities for research were chosen and developed, and in how
the research projects were commissioned. The ideological and methodological debates associated
with these decisions have continued among those working in this field. The need for an effective
communication strategy for the programme as a whole was particularly important. However, such
a strategy was never developed, making it difficult to establish the general influence of the IMP as a
programme.
Conclusion: Our findings about the impact of the work funded, and the difficulties faced by those
developing the IMP, have implications for the development of strategic programmes of research in
general, as well as for the development of more effective research in this field
Search for a T-odd, P-even Triple Correlation in Neutron Decay
Background: Time-reversal-invariance violation, or equivalently CP violation,
may explain the observed cosmological baryon asymmetry as well as signal
physics beyond the Standard Model. In the decay of polarized neutrons, the
triple correlation D\cdot(p_{e}\timesp_{\nu}) is a parity-even,
time-reversal- odd observable that is uniquely sensitive to the relative phase
of the axial-vector amplitude with respect to the vector amplitude. The triple
correlation is also sensitive to possible contributions from scalar and tensor
amplitudes. Final-state effects also contribute to D at the level of 1e-5 and
can be calculated with a precision of 1% or better. Purpose: We have improved
the sensitivity to T-odd, P-even interactions in nuclear beta decay. Methods:
We measured proton-electron coincidences from decays of longitudinally
polarized neutrons with a highly symmetric detector array designed to cancel
the time-reversal-even, parity-odd Standard-Model contributions to polarized
neutron decay. Over 300 million proton-electron coincidence events were used to
extract D and study systematic effects in a blind analysis. Results: We find D
= [-0.94\pm1.89(stat)\pm0.97(sys)]e-4. Conclusions: This is the most sensitive
measurement of D in nuclear beta decay. Our result can be interpreted as a
measurement of the phase of the ratio of the axial-vector and vector coupling
constants (CA/CV= |{\lambda}|exp(i{\phi}_AV)) with {\phi}_AV = 180.012{\deg}
\pm0.028{\deg} (68% confidence level) or to constrain time-reversal violating
scalar and tensor interactions that arise in certain extensions to the Standard
Model such as leptoquarks. This paper presents details of the experiment,
analysis, and systematic- error corrections.Comment: 21 pages, 22 figure
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