Measuring the Inventor\u27s Contribution

All inventors should be compensated for the value of their contributions. Inventors contribute both to the patent system and to the technology commercialization process by providing access to a qualifying disclosure describing a qualifying idea. Yet today, a schism divides the patent world and the commercial world over the value of these inventive contributions. Unlike the commercial world, the patent world pays inventors for the contributions of noninventor technology commercialization roles. In particular, seminal reasonable royalty cases like Georgia-Pacific and TWM Manufacturing allow patentees to recover infringer profits and proxies thereof—in violation of congressional mandate and the Supreme Court’s opinion in Aro Manufacturing. These cases perpetuate the schism and contribute to the patent system’s most consequential policy issues. Courts can close the schism and address these policy issues by removing measurement errors in reasonable royalty calculations. Instead of “indirectly” measuring compensatory damages based on the value of the infringer’s implementation, courts should set reasonable royalties based on “direct” measurements of the inventor’s contribution. Unlike indirect measurements, direct measurements ensure compliance with Aro Manufacturing. By adopting direct measurement techniques, courts can help all inventors receive compensation for the value of their contributions

Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition

The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain overexpressing AC1 in the forebrain. Here we report that AC1+ mice exhibit hyperactive behaviors and demonstrate increased impulsivity and reduced sociability. In contrast, AC1 and AC8 double knock-out mice are hypoactive, and exhibit increased sociability and reduced impulsivity. Interestingly, the hyperactivity of AC1+ mice can be corrected by valproate, a mood-stabilizing drug. These data indicate that increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition

Economic Analysis of Management Practices to Reduce Phosphorus Load to Lake Eucha and Spavinaw

Changes in management practices are often proposed to reduce phosphorus loading from a watershed due to over application of poultry litter. This study determines the choice, location, and level of each best management practice in the watershed to meet a Total Maximum Daily Load and margins of safety at least cost.best management practice, phosphorus runoff, poultry litter, Target MOTAD, Environmental Economics and Policy,