Pragmatic language disorder in Parkinson's disease and the potential effect of cognitive reserve

It is known that patients with Parkinson\u2019s Disease (PD) may show deficits in several areas of cognition, including speech and language abilities. One domain of particular interest is pragmatics, which refers to the capacity of using language in context for a successful communication. Several studies showed that some specific aspects of pragmatics \u2013 both in production and in comprehension \u2013 might be impaired in patients with PD. However, a clear picture of pragmatic abilities in PD is still missing, as most of the existing studies focused on specific aspects of the pragmatic competence rather than on sketching a complete pragmatic profile. Moreover, little is known on the potential role of protective factors in compensating the decline of communicative skills as the disease progresses. The present study has two aims: (1) to provide a complete picture of pragmatic abilities in patients with PD, by using a comprehensive battery (Assessment of Pragmatic Abilities and Cognitive Substrates, APACS) and by investigating the relationship with other aspects of cognitive functioning (e.g., working memory and Theory of Mind) and (2) to investigate whether Cognitive Reserve, i.e., the resilience to cognitive impairment provided by life experiences and activities, may compensate for the progressive pragmatic deficits in PD. We found that patients with PD, compared to healthy matched controls, had worse performance in discourse production and in the description of scenes, and that these impairments were tightly correlated with the severity of motor impairment, suggesting reduced intentionality of engaging in a communicative exchange. Patients with PD showed also an impairment in comprehending texts and humor, suggesting a problem in inferring from stories, which was related to general cognitive impairment. Notably, we did not find any significant difference between patients and controls in figurative language comprehension, a domain that is commonly impaired in other neurodegenerative diseases. This might be indicative of a specific profile of pragmatic impairment in patients with PD, worth of further investigation. Finally, Cognitive Reserve measures showed a high degree of association with pragmatic comprehension abilities, suggesting that the modification of life-styles could be a good candidate for compensating the possible problems in understanding the pragmatic aspects of language experienced by patients with PD

Extended Optical Model Analyses of Elastic Scattering and Fusion Cross Sections for 6Li + 208Pb System at Near-Coulomb-Barrier Energies by using Folding Potential

Based on the extended optical model approach in which the polarization potential is decomposed into direct reaction (DR) and fusion parts, simultaneous $\chi^{2}$ analyses are performed for elastic scattering and fusion cross section data for the $^{6}$Li+$^{208}$Pb system at near-Coulomb-barrier energies. A folding potential is used as the bare potential. It is found that the real part of the resultant DR part of the polarization potential is repulsive, which is consistent with the results from the Continuum Discretized Coupled Channel (CDCC) calculations and the normalization factors needed for the folding potentials. Further, it is found that both DR and fusion parts of the polarization potential satisfy separately the dispersion relation.Comment: 6 figure

A Fuzzy Logic-based Tuning Approach of PID Control for Steam Turbines for Solar Applications

Abstract This work aims at improving the control concept based on PID controller by jointly exploiting experience and knowledge on the system behaviour and artificial intelligence. A Concentrated Solar Power Plant (CSPP) system has been modelled and a stability and performance analysis has been carried out, focusing on power control loop, which is normally based on standard PID. A hybrid fuzzy PID approach is proposed to improve the steam turbine governor action and its performance are compared to the classical PID tuned according to three different approaches. Compared to the classic PID, the PID fuzzy logic controller extends the simplicity of PID and adapts the control action at actual operating condition by providing the system with a sort of "decision-making skill". The possibility to design implementable algorithms on PLC, which have stringent computational speed and memory requirements, has been explicitly taken into account in the developed work

analysis of a simplified steam turbine governor model for power system stability studies

Abstract The present study describes an analysis performed on a simplified Steam Turbine governor model, which is useful for pre-tuning the machine regulation system. A dynamic model has been implemented in two different simulation tools, namely DigSILENT PowerFactory and Matlab/Simulink, to the aim of verifying the suitability of the latter one for power system stability studies. The proposed work paves the way to the wide range of possibilities connected to the integration of the machine governor model with other simulation blocks of a Combined Cycle Plant, by enabling the opportunity for pre-commissioning of the regulation system together with the analysis of the fulfillment of grid code regulations

Effect of continuum couplings in fusion of halo 11^{11}Be on 208^{208}Pb around the Coulomb barrier

The effect of continuum couplings in the fusion of the halo nucleus $^{11}$Be on $^{208}$Pb around the Coulomb barrier is studied using a three-body model within a coupled discretised continuum channels (CDCC) formalism. We investigate in particular the role of continuum-continuum couplings. These are found to hinder total, complete and incomplete fusion processes. Couplings to the projectile $1p_{1/2}$ bound excited state redistribute the complete and incomplete fusion cross sections, but the total fusion cross section remains nearly constant. Results show that continuum-continuum couplings enhance the irreversibility of breakup and reduce the flux that penetrates the Coulomb barrier. Converged total fusion cross sections agree with the experimental ones for energies around the Coulomb barrier, but underestimate those for energies well above the Coulomb barrier.Comment: 15 pages, 7 figures, accepted in Phys. Rev.

Detection and isolation of circulating tumor cells with single-cell resolution: A successful lab-on-a-chip device

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.This paper presents the unique features of DEPArray™ an automated system enabling image-based cell sorting with single-cell resolution and describes its potential application in the field of oncology

Extended Optical Model Analyses of Elastic Scattering, Direct Reaction, and Fusion Cross Sections for the 9Be + 208Pb System at Near-Coulomb-Barrier Energies

Based on the extended optical model approach in which the polarization potential is decomposed into direct reaction (DR) and fusion parts, simultaneous $\chi^{2}$ analyses are performed for elastic scattering, DR, and fusion cross section data for the $^{9}$Be+$^{208}$Pb system at near-Coulomb-barrier energies. Similar $\chi^{2}$ analyses are also performed by only taking into account the elastic scattering and fusion data as was previously done by the present authors, and the results are compared with those of the full analysis including the DR cross section data as well. We find that the analyses using only elastic scattering and fusion data can produce very consistent and reliable predictions of cross sections particularly when the DR cross section data are not complete. Discussions are also given on the results obtained from similar analyses made earlier for the $^{9}$Be+$^{209}$Bi system.Comment: 5 figure

Patient- and parent-reported outcome measures of developmental adaptive abilities in visually impaired children: The Visual Impairment Developmental Autonomy (VIDA) scale

In the pediatric context, parents’ and patients’ engagement in the care process is strongly recommended and could be pursued using patient-reported outcome measures (PROMs), which therefore become useful for planning and monitoring treatments. Nevertheless, few data are available from families of children with neurodevelopmental disorders such as visual impairment (VI). The Visual Impairment Developmental Autonomy (VIDA) project aims to develop and validate a patient- and parent-reported tool to measure the most relevant aspects concerning everyday adaptive abilities in children and adolescents with visual impairment: the VIDA scale. The present paper illustrates the Delphi process of item generation engaging parents and patients and presents a protocol for the validation of this new co-designed tool in an Italian visually impaired pediatric population. Twenty-three families and five adolescents provided a list of 192 items and assessed their relevance. Items were categorized in 5 areas of adaptive abilities (i.e., table manners, clothing, personal hygiene, orientation and mobility, and socio-affectivity) and into three age ranges based on the patient's age. The final 102-item Vida Scale will be administered to a minimum of 300 visually impaired children together with measures of quality of life and child adjustment to investigate its psychometric properties

The Use of Antimalarial Drugs against Viral Infection

In recent decades, drugs used to treat malaria infection have been shown to be beneficial for many other diseases, including viral infections. In particular, they have received special attention due to the lack of effective antiviral drugs against new emerging viruses (i.e., HIV, dengue virus, chikungunya virus, Ebola virus, etc.) or against classic infections due to drug-resistant viral strains (i.e., human cytomegalovirus). Here, we reviewed the in vitro/in vivo and clinical studies conducted to evaluate the antiviral activities of four classes of antimalarial drugs: Artemisinin derivatives, aryl-aminoalcohols, aminoquinolines, and antimicrobial drugs